Antibiotic regimens for neonatal sepsis - a protocol for a systematic review with meta-analysis.
Antibiotics
Infants
Neonates
Sepsis
Septic shock
Systematic review
Journal
Systematic reviews
ISSN: 2046-4053
Titre abrégé: Syst Rev
Pays: England
ID NLM: 101580575
Informations de publication
Date de publication:
05 12 2019
05 12 2019
Historique:
received:
04
07
2019
accepted:
22
10
2019
entrez:
7
12
2019
pubmed:
7
12
2019
medline:
17
9
2020
Statut:
epublish
Résumé
Sepsis is a major cause of morbidity and mortality among neonates and infants. Antibiotics are a central part of the first line treatment for sepsis in neonatal intensive care units worldwide. However, the evidence on the clinical effects of the commonly used antibiotic regimens for sepsis in neonates remains scarce. This systematic review aims to assess the efficacy and harms of antibiotic regimens for neonatal sepsis. Electronic searches will be conducted in MEDLINE, Embase, The Cochrane Library, CINAHL, ZETOC and clinical trial registries (clinicaltrials.gov and ISRCTN). We will include randomised controlled trials of different antibiotic regimens for sepsis of neonates and infants. Eligible interventions will be any antibiotic regimen. Two reviewers will independently screen, select, and extract data. The methodological quality of individual studies will be appraised following Cochrane methodology. Primary outcomes will be 'all-cause mortality' and 'serious adverse events'. Secondary outcomes will be 'need for respiratory support', 'need for circulatory support', 'neurodevelopmental impairment', ototoxicity, nephrotoxicity and necrotizing enterocolitis. We plan to perform a meta-analysis with trial sequential analysis. This is the study protocol for a systematic review on the effects of different antibiotic regimens for neonatal sepsis. The results of this systematic review intent to adequately inform stakeholders or health care professionals in the field of neonatal sepsis, and to aid appropriate development of treatment guidelines. PROSPERO reference number: CRD42019134300.
Sections du résumé
BACKGROUND
Sepsis is a major cause of morbidity and mortality among neonates and infants. Antibiotics are a central part of the first line treatment for sepsis in neonatal intensive care units worldwide. However, the evidence on the clinical effects of the commonly used antibiotic regimens for sepsis in neonates remains scarce. This systematic review aims to assess the efficacy and harms of antibiotic regimens for neonatal sepsis.
METHODS
Electronic searches will be conducted in MEDLINE, Embase, The Cochrane Library, CINAHL, ZETOC and clinical trial registries (clinicaltrials.gov and ISRCTN). We will include randomised controlled trials of different antibiotic regimens for sepsis of neonates and infants. Eligible interventions will be any antibiotic regimen. Two reviewers will independently screen, select, and extract data. The methodological quality of individual studies will be appraised following Cochrane methodology. Primary outcomes will be 'all-cause mortality' and 'serious adverse events'. Secondary outcomes will be 'need for respiratory support', 'need for circulatory support', 'neurodevelopmental impairment', ototoxicity, nephrotoxicity and necrotizing enterocolitis. We plan to perform a meta-analysis with trial sequential analysis.
DISCUSSION
This is the study protocol for a systematic review on the effects of different antibiotic regimens for neonatal sepsis. The results of this systematic review intent to adequately inform stakeholders or health care professionals in the field of neonatal sepsis, and to aid appropriate development of treatment guidelines.
SYSTEMATIC REVIEW REGISTRATION
PROSPERO reference number: CRD42019134300.
Identifiants
pubmed: 31805993
doi: 10.1186/s13643-019-1207-1
pii: 10.1186/s13643-019-1207-1
pmc: PMC6896287
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
306Références
Lancet. 2012 Jun 9;379(9832):2151-61
pubmed: 22579125
Infect Chemother. 2013 Sep;45(3):343-5
pubmed: 24396638
Control Clin Trials. 1986 Sep;7(3):177-88
pubmed: 3802833
Pediatrics. 2008 Apr;121(4):697-702
pubmed: 18381533
Arch Dis Child Fetal Neonatal Ed. 2005 May;90(3):F220-4
pubmed: 15846011
Stat Med. 2002 Jun 15;21(11):1539-58
pubmed: 12111919
J Hosp Infect. 2000 Jan;44(1):13-7
pubmed: 10633048
Arch Dis Child Fetal Neonatal Ed. 2011 Jan;96(1):F9-F14
pubmed: 20876594
Arch Dis Child Fetal Neonatal Ed. 2015 Jul;100(4):F350-4
pubmed: 25425652
J Antibiot (Tokyo). 2005 Jan;58(1):1-26
pubmed: 15813176
Antimicrob Agents Chemother. 2010 Nov;54(11):4851-63
pubmed: 20733044
Lancet. 2005 Mar 5-11;365(9462):891-900
pubmed: 15752534
Ceylon Med J. 1999 Jun;44(2):81-6
pubmed: 10565074
Acta Paediatr. 2012 Feb;101(2):120-7
pubmed: 22003882
Arch Dis Child Fetal Neonatal Ed. 2003 Mar;88(2):F89-93
pubmed: 12598493
Lancet. 2016 Feb 6;387(10018):533-534
pubmed: 26867442
Scand J Immunol. 2011 Jan;73(1):53-8
pubmed: 21129003
J Clin Epidemiol. 2008 Jan;61(1):64-75
pubmed: 18083463
JAMA. 2016 Feb 23;315(8):801-10
pubmed: 26903338
J Pediatr. 1978 Apr;92(4):529-34
pubmed: 305471
Stat Med. 1987 Apr-May;6(3):341-50
pubmed: 3616287
Rev Infect Dis. 1985 Nov-Dec;7 Suppl 4:S559-71
pubmed: 3909313
N Engl J Med. 1994 Apr 28;330(17):1229-30
pubmed: 8139634
Paediatr Drugs. 2014 Feb;16(1):67-81
pubmed: 24218112
Cochrane Database Syst Rev. 2005 Jul 20;(3):CD004501
pubmed: 16034935
Pediatr Neonatol. 2016 Aug;57(4):265-73
pubmed: 26750406
N Engl J Med. 2002 Jul 25;347(4):240-7
pubmed: 12140299
Arch Dis Child Fetal Neonatal Ed. 2005 Jul;90(4):F324-7
pubmed: 15878934
Semin Perinatol. 2003 Aug;27(4):293-301
pubmed: 14510320
BMJ. 2015 Jan 02;350:g7647
pubmed: 25555855
Curr Pharm Des. 2007;13(1):119-26
pubmed: 17266591
Am J Epidemiol. 2006 Mar 15;163(6):493-501
pubmed: 16443796
Pediatr Infect Dis J. 2016 Jul;35(7):e191-8
pubmed: 27031259
Mycopathologia. 2012 Apr;173(4):219-28
pubmed: 22076411
J Pediatr. 2015 May;166(5):1193-9
pubmed: 25919728
Pediatrics. 2010 Apr;125(4):e736-40
pubmed: 20231184
J Immunol. 2012 Dec 1;189(11):5449-56
pubmed: 23105134
Pediatr Infect Dis J. 2014 Jan;33(1):e7-e13
pubmed: 23899966
J Pediatr. 2011 Nov;159(5):720-5
pubmed: 21784435
Arch Dis Child Fetal Neonatal Ed. 2015 May;100(3):F257-63
pubmed: 25425653
Pediatr Infect Dis J. 2014 Mar;33(3):238-43
pubmed: 24030351
Pediatrics. 2006 Jan;117(1):67-74
pubmed: 16396862
Curr Opin Pediatr. 2016 Apr;28(2):135-40
pubmed: 26766602
Infect Control Hosp Epidemiol. 2003 Sep;24(9):662-6
pubmed: 14510248
Bangladesh Med Res Counc Bull. 2011 Aug;37(2):40-6
pubmed: 21877603
Lancet. 2003 Jun 7;361(9373):1953-4
pubmed: 12801740
J Intern Med. 1998 Nov;244(5):379-86
pubmed: 9845853
Pediatrics. 2002 Oct;110(4):e42
pubmed: 12359815
Cochrane Database Syst Rev. 2004 Oct 18;(4):CD004495
pubmed: 15495114
Eur J Clin Microbiol. 1987 Jun;6(3):234-44
pubmed: 3305004
Rev Infect Dis. 1990 Jan-Feb;12(1):12-9
pubmed: 2405465
Pediatrics. 2002 Aug;110(2 Pt 1):285-91
pubmed: 12165580
Pediatr Infect Dis J. 2015 Mar;34(3):267-72
pubmed: 25191849
Trop Med Int Health. 2015 Dec;20(12):1593-606
pubmed: 26426298
Ann Intern Med. 2012 Sep 18;157(6):429-38
pubmed: 22945832
Pediatr Infect Dis J. 2005 Jul;24(7):635-9
pubmed: 15999007
Pediatr Infect Dis J. 2009 Jan;28(1 Suppl):S10-8
pubmed: 19106757
Immunity. 2014 Apr 17;40(4):463-75
pubmed: 24745331
Pediatr Emerg Care. 2013 May;29(5):641-3
pubmed: 23603656
Pediatrics. 2006 Jan;117(1):84-92
pubmed: 16396864
Trends Mol Med. 2016 Apr;22(4):290-302
pubmed: 26993220
Arch Dis Child. 1985 Jun;60(6):542-6
pubmed: 3925895
Crit Care Med. 2010 Apr;38(4):1045-53
pubmed: 20048677
Indian J Pediatr. 1986 Jul-Aug;53(4):509-14
pubmed: 3542818
Acta Paediatr Scand. 1990 Nov;79(11):1023-30
pubmed: 2267918
Lancet. 2016 Jan 30;387(10017):444-52
pubmed: 26564381
J Infect. 2014 Jan;68 Suppl 1:S24-32
pubmed: 24140138
Am J Perinatol. 2013 Feb;30(2):131-41
pubmed: 23297182
Pediatr Infect Dis J. 2011 Nov;30(11):937-41
pubmed: 21654548
J Infect Dis. 1971 Dec;124 Suppl:S145-7
pubmed: 5126240
Pharmacotherapy. 2009 Nov;29(11):1275-9
pubmed: 19873687
Infect Control Hosp Epidemiol. 2001 Nov;22(11):723-5
pubmed: 11842996
BMC Med Res Methodol. 2014 Nov 21;14:120
pubmed: 25416419
J Trop Pediatr. 2008 Oct;54(5):291-3
pubmed: 18710895
Infect Control Hosp Epidemiol. 1994 Jul;15(7):478-83
pubmed: 7963440
Pediatr Infect Dis J. 2000 Mar;19(3):200-6
pubmed: 10749459
Intensive Care Med. 2013 Feb;39(2):165-228
pubmed: 23361625
BMC Pregnancy Childbirth. 2012 Jun 12;12:48
pubmed: 22691696
Intensive Care Med. 2007 Jul;33(7):1272-1283
pubmed: 17503015
Arch Dis Child Fetal Neonatal Ed. 2011 Jan;96(1):F4-8
pubmed: 20584804
Chest. 2000 Jul;118(1):146-55
pubmed: 10893372
PLoS Med. 2006 Feb;3(2):e29
pubmed: 16398572
Clin Dev Immunol. 2013;2013:586076
pubmed: 23762094
Science. 1992 Aug 21;257(5073):1050-5
pubmed: 1509255
Can J Infect Dis. 1996 Mar;7(2):104-9
pubmed: 22514426
Clin Perinatol. 2012 Mar;39(1):61-8
pubmed: 22341537
J Trop Pediatr. 2015 Feb;61(1):1-13
pubmed: 25604489
CMAJ. 2015 Jan 6;187(1):E21-E31
pubmed: 25404399
Pediatr Infect Dis J. 1994 Jun;13(6):516-20
pubmed: 8078740
Pediatr Crit Care Med. 2014 Jul;15(6):523-8
pubmed: 24751791
Indian J Pediatr. 2000 Mar;67(3):169-74
pubmed: 10838717
J Immunol. 2007 Jan 15;178(2):1180-8
pubmed: 17202383
Clin Microbiol Rev. 2012 Jul;25(3):450-70
pubmed: 22763634
Lancet. 2017 Oct 14;390(10104):1770-1780
pubmed: 28434651
J Pediatr. 1996 Jul;129(1):63-71
pubmed: 8757564
J Pediatr. 2013 Jun;162(6):1120-4, 1124.e1
pubmed: 23324523
Curr Opin Infect Dis. 2015 Jun;28(3):225-30
pubmed: 25887615
Pediatrics. 2011 Aug;128(2):e348-57
pubmed: 21768312
Pediatrics. 2006 Aug;118(2):717-22
pubmed: 16882828
Int J Epidemiol. 2009 Feb;38(1):276-86
pubmed: 18824467
Mycologia. 1947 Sep-Oct;39(5):565-9
pubmed: 20264541
J Clin Epidemiol. 2008 Aug;61(8):763-9
pubmed: 18411040
Lancet. 2005 Mar 26-Apr 1;365(9465):1175-88
pubmed: 15794973
Med J Malaysia. 1995 Mar;50(1):59-63
pubmed: 7752978
Immunol Lett. 2016 May;173:42-54
pubmed: 26994839
BMJ. 2008 Mar 15;336(7644):601-5
pubmed: 18316340
Pediatrics. 2011 May;127(5):817-26
pubmed: 21518717
Ann Surg. 1978 Jan;187(1):1-7
pubmed: 413500
Ann Intern Med. 2001 Dec 4;135(11):982-9
pubmed: 11730399
Pediatr Infect Dis J. 1999 Oct;18(10 Suppl):S23-31
pubmed: 10530570
Pediatrics. 2009 Jan;123(1):58-66
pubmed: 19117861
Pediatr Clin North Am. 2013 Apr;60(2):367-89
pubmed: 23481106
J Infect Dis. 1971 Dec;124 Suppl:S130-7
pubmed: 5126239
Lancet. 1998 Aug 22;352(9128):609-13
pubmed: 9746022
BMC Infect Dis. 2016 Oct 20;16(1):587
pubmed: 27765017
Int J Epidemiol. 2009 Feb;38(1):287-98
pubmed: 18824466
J Antimicrob Chemother. 1989 Sep;24(3):281-93
pubmed: 2681115
Pediatrics. 2006 Jun;117(6):1979-87
pubmed: 16740839
Ital J Pediatr. 2015 Apr 01;41:27
pubmed: 25887621
BMC Med Res Methodol. 2009 Dec 30;9:86
pubmed: 20042080
Acta Paediatr. 2014 Dec;103(12):1211-8
pubmed: 25073543
Indian J Pathol Microbiol. 2007 Jul;50(3):669-70
pubmed: 17883180
Antimicrob Agents Chemother. 1999 May;43(5):1003-12
pubmed: 10223907
J Clin Epidemiol. 2009 Oct;62(10):1006-12
pubmed: 19631508
J Pharm Pract. 2014 Dec;27(6):573-7
pubmed: 25199523
Antimicrob Agents Chemother. 1983 Jan;23(1):138-41
pubmed: 6219616
Pediatrics. 2008 Apr;121(4):689-96
pubmed: 18381532
Int J Otolaryngol. 2011;2011:937861
pubmed: 22121370
Arch Med Sci. 2016 Jun 1;12(3):603-13
pubmed: 27279855
Acta Paediatr. 1993 Aug;82(8):687-9
pubmed: 8374220
Virulence. 2014 Jan 1;5(1):170-8
pubmed: 24185532
BMC Med Res Methodol. 2017 Mar 6;17(1):39
pubmed: 28264661
J Antimicrob Chemother. 1985 Aug;16(2):235-41
pubmed: 3934126
BMJ. 2003 Sep 6;327(7414):557-60
pubmed: 12958120