Impaired training-induced angiogenesis process with loss of pericyte-endothelium interactions is associated with an abnormal capillary remodelling in the skeletal muscle of COPD patients.
Angiogenesis Inducing Agents
/ administration & dosage
Biopsy, Needle
Capillaries
/ pathology
Exercise
Exercise Therapy
/ methods
Female
Humans
Immunohistochemistry
Male
Middle Aged
Muscle, Skeletal
/ blood supply
Neovascularization, Physiologic
/ physiology
Oxidative Stress
Pulmonary Disease, Chronic Obstructive
/ pathology
Reference Values
Vascular Remodeling
Angiogenesis
COPD
Capillaries
Exercise training
Skeletal muscle
Journal
Respiratory research
ISSN: 1465-993X
Titre abrégé: Respir Res
Pays: England
ID NLM: 101090633
Informations de publication
Date de publication:
05 Dec 2019
05 Dec 2019
Historique:
received:
09
08
2019
accepted:
13
11
2019
entrez:
7
12
2019
pubmed:
7
12
2019
medline:
6
5
2020
Statut:
epublish
Résumé
Chronic obstructive pulmonary disease (COPD) is associated with exercise intolerance and limits the functional gains in response to exercise training in patients compared to sedentary healthy subjects (SHS). The blunted skeletal muscle angiogenesis previously observed in COPD patients has been linked to these limited functional improvements, but its underlying mechanisms, as well as the potential role of oxidative stress, remain poorly understood. Therefore, we compared ultrastructural indexes of angiogenic process and capillary remodelling by transmission electron microscopy in 9 COPD patients and 7 SHS after 6 weeks of individualized moderate-intensity endurance training. We also assessed oxidative stress by plasma-free and esterified isoprostane (F
Identifiants
pubmed: 31806021
doi: 10.1186/s12931-019-1240-6
pii: 10.1186/s12931-019-1240-6
pmc: PMC6896673
doi:
Substances chimiques
Angiogenesis Inducing Agents
0
Types de publication
Comparative Study
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
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