Epstein-Barr Virus-Associated Smooth Muscle Tumor of the Spine After Bone Marrow Transplant: Case Report and Review of Literature.
Decompression, Surgical
Epstein-Barr Virus Infections
/ immunology
Hematopoietic Stem Cell Transplantation
Humans
Immunocompromised Host
Immunosuppressive Agents
/ adverse effects
Lymphoma, Large B-Cell, Diffuse
/ therapy
Male
Middle Aged
Optic Neuritis
/ drug therapy
Smooth Muscle Tumor
/ diagnostic imaging
Spinal Fusion
Spinal Neoplasms
/ diagnostic imaging
Thoracic Vertebrae
Bone marrow transplant
Epstein-Barr virus
Smooth muscle tumor
Spine
Journal
World neurosurgery
ISSN: 1878-8769
Titre abrégé: World Neurosurg
Pays: United States
ID NLM: 101528275
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
28
10
2019
revised:
26
11
2019
accepted:
27
11
2019
pubmed:
7
12
2019
medline:
25
3
2020
entrez:
7
12
2019
Statut:
ppublish
Résumé
Epstein-Barr virus-associated smooth muscle tumors (SMTs) are rare neoplasms that have been found to develop in immunocompromised patients. Three distinct groups of affected patients have been described: (1) human immunodeficiency virus-infected patients, (2) post-transplant patients, and (3) patients with congenital immunodeficiency. The tumors can develop anywhere in the body, with 17 reported cases occurring in the spinal canal, all in patients with human immunodeficiency virus infection. We report the first case of Epstein-Barr virus-associated SMT affecting the spinal canal in a post-bone marrow transplant adult patient. Interestingly, unlike other reported cases, the patient described here had not been receiving immunosuppressive therapy in the 2 years prior to diagnosis of the tumor. Despite the growing number of case reports, this diagnosis presents a challenge, as the pathophysiology and optimal treatment regimens are not well understood. Results of a literature review of Epstein-Barr virus-associated SMT of the spine as well as a discussion of the presentation, management, and prognosis of this condition is presented here.
Sections du résumé
BACKGROUND
BACKGROUND
Epstein-Barr virus-associated smooth muscle tumors (SMTs) are rare neoplasms that have been found to develop in immunocompromised patients. Three distinct groups of affected patients have been described: (1) human immunodeficiency virus-infected patients, (2) post-transplant patients, and (3) patients with congenital immunodeficiency. The tumors can develop anywhere in the body, with 17 reported cases occurring in the spinal canal, all in patients with human immunodeficiency virus infection.
CASE DESCRIPTION
METHODS
We report the first case of Epstein-Barr virus-associated SMT affecting the spinal canal in a post-bone marrow transplant adult patient. Interestingly, unlike other reported cases, the patient described here had not been receiving immunosuppressive therapy in the 2 years prior to diagnosis of the tumor.
CONCLUSIONS
CONCLUSIONS
Despite the growing number of case reports, this diagnosis presents a challenge, as the pathophysiology and optimal treatment regimens are not well understood. Results of a literature review of Epstein-Barr virus-associated SMT of the spine as well as a discussion of the presentation, management, and prognosis of this condition is presented here.
Identifiants
pubmed: 31809898
pii: S1878-8750(19)33010-4
doi: 10.1016/j.wneu.2019.11.160
pii:
doi:
Substances chimiques
Immunosuppressive Agents
0
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
192-196Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.