A Computationally Optimized Broadly Reactive Antigen Subtype-Specific Influenza Vaccine Strategy Elicits Unique Potent Broadly Neutralizing Antibodies against Hemagglutinin.
Animals
Antibodies, Monoclonal
/ chemistry
Antibodies, Viral
/ chemistry
Broadly Neutralizing Antibodies
/ chemistry
Computational Biology
Dogs
Epitope Mapping
Epitopes, B-Lymphocyte
/ genetics
Female
Hemagglutinin Glycoproteins, Influenza Virus
/ genetics
Humans
Influenza A Virus, H1N1 Subtype
/ physiology
Influenza Vaccines
/ immunology
Influenza, Human
/ immunology
Madin Darby Canine Kidney Cells
Mice
Mice, Inbred BALB C
Orthomyxoviridae Infections
/ immunology
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
15 01 2020
15 01 2020
Historique:
received:
01
04
2019
accepted:
07
11
2019
pubmed:
8
12
2019
medline:
11
8
2020
entrez:
8
12
2019
Statut:
ppublish
Résumé
Computationally optimized broadly reactive Ags (COBRA) targeting H1 elicit a broad cross-reactive and cross-neutralizing Ab response against multiple H1N1 viral strains. To assess B cell breadth,
Identifiants
pubmed: 31811019
pii: jimmunol.1900379
doi: 10.4049/jimmunol.1900379
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antibodies, Viral
0
Broadly Neutralizing Antibodies
0
Epitopes, B-Lymphocyte
0
H1N1 virus hemagglutinin
0
Hemagglutinin Glycoproteins, Influenza Virus
0
Influenza Vaccines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
375-385Informations de copyright
Copyright © 2020 by The American Association of Immunologists, Inc.