The impact of low-dose versus high-dose antibiotic prophylaxis regimens on surgical site infection rates after cesarean delivery.
Antibiotics
Cesarean
Infection
Pregnancy
Prophylaxis
Wound
Journal
Archives of gynecology and obstetrics
ISSN: 1432-0711
Titre abrégé: Arch Gynecol Obstet
Pays: Germany
ID NLM: 8710213
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
11
07
2019
accepted:
30
10
2019
pubmed:
8
12
2019
medline:
9
7
2020
entrez:
8
12
2019
Statut:
ppublish
Résumé
The objective of this study was to determine if high-dose antibiotic prophylaxis with cefazolin decreases the risk of surgical site infection (SSI) after a cesarean delivery. We performed a retrospective cohort study of women who underwent a cesarean section. Two preoperative antibiotic regimens were compared: low dose versus high dose. The primary outcome was SSI. A sample size of 343 patients per group was calculated for a 50% reduction in risk for SSI. Seven hundred and thirty women were included with an incidence of SSI of 5%. Women who received the high-dose antibiotic regimen had lower rates of risk factors for SSI. The only exception was skin incision closure with staples. The rate of SSI did not differ between the low-dose and high-dose groups, even after adjusting for confounding variables [aOR 1.78, 95% CI (0.82-3.9)]. Higher doses of antibiotic prophylaxis did not decrease the rates of SSI after cesarean delivery.
Identifiants
pubmed: 31811413
doi: 10.1007/s00404-019-05370-y
pii: 10.1007/s00404-019-05370-y
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
69-73Références
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