Clinical quantification of the integrin αvβ6 by [
Biomarker
Clinical study
Idiopathic pulmonary fibrosis
PET
Pulmonary fibrosis
[18F]FB-A20FMDV2 PET/CT
αvβ6 integrin
Journal
European journal of nuclear medicine and molecular imaging
ISSN: 1619-7089
Titre abrégé: Eur J Nucl Med Mol Imaging
Pays: Germany
ID NLM: 101140988
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
25
07
2019
accepted:
16
10
2019
pubmed:
10
12
2019
medline:
15
5
2021
entrez:
10
12
2019
Statut:
ppublish
Résumé
The RGD-integrin, αvβ6, plays a role in the pathogenesis of pulmonary fibrosis through activation of transforming growth factor beta (TGFβ). This study sought to quantify expression of αvβ6 in the lungs of healthy humans and subjects with pulmonary fibrosis using the αvβ6-selective [ [ A total of 15 participants (6 healthy, 7 with idiopathic pulmonary fibrosis (IPF) and 2 with connective tissue disease (CTD) associated PF) were enrolled. V Lung uptake of [
Identifiants
pubmed: 31814068
doi: 10.1007/s00259-019-04586-z
pii: 10.1007/s00259-019-04586-z
pmc: PMC7075837
doi:
Substances chimiques
Antigens, Neoplasm
0
Integrins
0
integrin alphavbeta6
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
967-979Subventions
Organisme : HSRD VA
ID : CDA 13-017
Pays : United States
Organisme : Department of Health
ID : CS-2013-13-017
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0901226
Pays : United Kingdom
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