Interleukin-4 Promotes Myogenesis and Boosts Myocyte Insulin Efficacy.
Animals
Biological Transport
/ drug effects
Blotting, Western
Cell Differentiation
/ drug effects
Cell Line
Glucose
/ metabolism
Glucose Transporter Type 4
/ metabolism
Interleukin-4
/ pharmacology
Male
Mice
Mice, Inbred C57BL
Microscopy, Fluorescence
Muscle Cells
/ drug effects
Muscle Development
/ drug effects
Myoblasts
/ drug effects
Reverse Transcriptase Polymerase Chain Reaction
Journal
Mediators of inflammation
ISSN: 1466-1861
Titre abrégé: Mediators Inflamm
Pays: United States
ID NLM: 9209001
Informations de publication
Date de publication:
2019
2019
Historique:
received:
10
04
2019
revised:
30
06
2019
accepted:
18
07
2019
entrez:
10
12
2019
pubmed:
10
12
2019
medline:
2
6
2020
Statut:
epublish
Résumé
Anti-inflammatory cytokine interleukin-4 (IL-4) promotes glucose tolerance and insulin sensitivity while reduces lipid deposits. However, the effects of IL-4 on energy metabolism in muscle, the largest insulin-targeting organ, remain obscure. The study aimed at addressing the roles of IL-4 in myocyte differentiation (myogenesis) and energy metabolism of muscle cells. Effects of IL-4 on myogenesis, and interaction between IL-4 and insulin on glucose metabolism of C2C12 myoblasts and the terminal differentiated myocytes were analyzed. IL-4 improved GLUT4 translocation and tended to elevate glucose uptake by boosting insulin signaling. In diabetic mice, transient and long-term IL-4 showed differential effects on insulin signaling and efficacy. The study provides evidence to address the roles of IL-4 in mediating whole-body muscle reservoir and glucose metabolism, as well as the interaction between immune responses and energy homeostasis. IL-4 has dual potential to act as an adjuvant therapeutic target for sarcopenia to preserve muscle mass and insulin resistance to improve insulin sensitivity, which implicates the regulation of immune system to the muscle differentiation and exercise performance.
Identifiants
pubmed: 31814802
doi: 10.1155/2019/4182015
pmc: PMC6878819
doi:
Substances chimiques
Glucose Transporter Type 4
0
Slc2a4 protein, mouse
0
Interleukin-4
207137-56-2
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4182015Informations de copyright
Copyright © 2019 Yih-Hsin Chang et al.
Déclaration de conflit d'intérêts
None.
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