Modulation of the immune microenvironment by tumor-intrinsic oncogenic signaling.
Journal
The Journal of cell biology
ISSN: 1540-8140
Titre abrégé: J Cell Biol
Pays: United States
ID NLM: 0375356
Informations de publication
Date de publication:
06 01 2020
06 01 2020
Historique:
received:
29
08
2019
revised:
06
11
2019
accepted:
07
11
2019
entrez:
10
12
2019
pubmed:
10
12
2019
medline:
28
7
2020
Statut:
ppublish
Résumé
The development of cancer immunotherapies has been guided by advances in our understanding of the dynamics between tumor cells and immune populations. An emerging consensus is that immune control of tumors is mediated by cytotoxic CD8+ T cells, which directly recognize and kill tumor cells. The critical role of T cells in tumor control has been underscored by preclinical and clinical studies that observed that T cell presence is positively correlated with patient response to checkpoint blockade therapy. However, the vast majority of patients do not respond or develop resistance, frequently associated with exclusion of T cells from the tumor microenvironment. This review focuses on tumor cell-intrinsic alterations that blunt productive anti-tumor immune responses by directly or indirectly excluding effector CD8+ T cells from the tumor microenvironment. A comprehensive understanding of the interplay between tumors and the immune response holds the promise for increasing the response to current immunotherapies via the development of rational novel combination treatments.
Identifiants
pubmed: 31816057
pii: 132612
doi: 10.1083/jcb.201908224
pmc: PMC7039199
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : R00 CA204595
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007287
Pays : United States
Informations de copyright
© 2019 Nguyen and Spranger.
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