Frequency and distribution of various rheumatic disorders associated with checkpoint inhibitor therapy.
Antineoplastic Agents, Immunological
/ adverse effects
Arthralgia
/ chemically induced
Arthritis
/ chemically induced
Humans
Immunologic Factors
/ adverse effects
Immunotherapy
/ adverse effects
Incidence
Myositis
/ chemically induced
Neoplasms
/ drug therapy
Polymyalgia Rheumatica
/ chemically induced
Rheumatic Diseases
/ chemically induced
Sjogren's Syndrome
/ chemically induced
cancer
immune checkpoint inhibitors
immune-related adverse events
rheumatic syndromes
Journal
Rheumatology (Oxford, England)
ISSN: 1462-0332
Titre abrégé: Rheumatology (Oxford)
Pays: England
ID NLM: 100883501
Informations de publication
Date de publication:
01 12 2019
01 12 2019
Historique:
received:
09
04
2019
revised:
17
06
2019
entrez:
10
12
2019
pubmed:
10
12
2019
medline:
4
4
2020
Statut:
ppublish
Résumé
Immune checkpoint inhibitors have advanced the treatment paradigm of various cancers, achieving remarkable survival benefits. However, a myriad of immune-related adverse events (irAE) has been recognized in almost every organ system, presumably because of persistent immune system activation. Rheumatic symptoms such as arthralgia or myalgia are very common. More specific irAE are increasingly being reported. The most frequent ones are inflammatory arthritis, polymyalgia-like syndromes, myositis and sicca manifestations. These rheumatic irAE can develop in ∼5-10% of patients treated with immune checkpoint inhibitors, although true incidence rates cannot be estimated given the lack of prospective cohort studies, and likely underreporting of rheumatic irAE in oncology trials. In this review, we will provide a summary of the epidemiologic data reported for these rheumatic irAE, until more robust prospective longitudinal studies become available to further define the true incidence rate of rheumatic irAE in patients receiving these novel cancer therapies.
Identifiants
pubmed: 31816084
pii: 5670496
doi: 10.1093/rheumatology/kez297
pmc: PMC6900912
doi:
Substances chimiques
Antineoplastic Agents, Immunological
0
Immunologic Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
vii40-vii48Informations de copyright
© The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology.
Références
Support Care Cancer. 2019 Feb;27(2):383-394
pubmed: 30353228
JAAD Case Rep. 2016 Jul 14;2(3):264-8
pubmed: 27486590
Melanoma Res. 2018 Oct;28(5):484-485
pubmed: 30148768
Clin Nucl Med. 2017 Sep;42(9):728-729
pubmed: 28737580
J Immunother Cancer. 2018 Jun 13;6(1):52
pubmed: 29898781
Eur J Cancer. 2018 Dec;105:88-102
pubmed: 30439628
Medicine (Baltimore). 2017 Jul;96(27):e7350
pubmed: 28682883
Semin Arthritis Rheum. 2019 Feb;48(4):736-740
pubmed: 29909921
Oncologist. 2019 May;24(5):584-588
pubmed: 30819785
Rev Mal Respir. 2018 Nov;35(9):963-967
pubmed: 30220489
Melanoma Res. 2018 Jun;28(3):230-236
pubmed: 29485531
Immunotherapy. 2017 Nov;9(14):1175-1183
pubmed: 29067884
J Immunother Cancer. 2018 Nov 16;6(1):120
pubmed: 30446009
Rheumatology (Oxford). 2017 Dec 1;56(12):2161
pubmed: 29029232
Semin Arthritis Rheum. 2017 Oct;47(2):281-287
pubmed: 28438383
Semin Arthritis Rheum. 2018 Jun;47(6):907-910
pubmed: 29191375
Clin Rheumatol. 2018 Apr;37(4):1107-1110
pubmed: 29455266
J Oncol Pharm Pract. 2017 Dec;23(8):620-624
pubmed: 27590328
J Immunother. 2017 Oct;40(8):307-311
pubmed: 28737620
J Dermatol. 2017 Aug;44(8):e196-e197
pubmed: 28391613
Ann Rheum Dis. 2017 Jan;76(1):43-50
pubmed: 27307501
Case Rep Oncol. 2017 Nov 27;10(3):1070-1075
pubmed: 29515398
Arthritis Rheumatol. 2014 Mar;66(3):768-9
pubmed: 24574239
Eur J Cancer. 2019 Jan;106:12-23
pubmed: 30453170
Ann Rheum Dis. 2018 Mar;77(3):393-398
pubmed: 29146737
RMD Open. 2017 Mar 20;3(1):e000412
pubmed: 28405474
Curr Opin Rheumatol. 2019 May;31(3):293-299
pubmed: 30870217
Curr Probl Cancer. 2017 Nov - Dec;41(6):407-412
pubmed: 29096940
Melanoma Res. 2017 Apr;27(2):171-173
pubmed: 28099367
Arthritis Care Res (Hoboken). 2019 Mar;71(3):362-366
pubmed: 29125905
J Immunother Cancer. 2017 Jul 18;5(1):54
pubmed: 28716137
Arthritis Rheumatol. 2016 Feb;68(2):556-7
pubmed: 26314277
BMJ Case Rep. 2016 Oct 26;2016:
pubmed: 27797838
BMJ. 2018 Mar 14;360:k793
pubmed: 29540345
Eur J Cancer. 2017 Sep;82:34-44
pubmed: 28646772
Ann Oncol. 2017 Dec 1;28(12):3108
pubmed: 29045656
JAMA Dermatol. 2015 Feb;151(2):195-9
pubmed: 25321335
J Immunother Cancer. 2018 Oct 11;6(1):104
pubmed: 30305172
J Thorac Oncol. 2018 Jun;13(6):e102-e103
pubmed: 29793647
Circulation. 2018 Aug 14;138(7):743-745
pubmed: 30359135
Am J Ther. 2018 May/Jun;25(3):e379-e380
pubmed: 28207422
Case Rep Hematol. 2018 Jan 11;2018:3106852
pubmed: 29581905
Dermatol Online J. 2017 Aug 15;23(8):
pubmed: 29469753
J Immunother Cancer. 2018 Dec 18;6(1):150
pubmed: 30563577
Rev Med Interne. 2018 Feb;39(2):130-133
pubmed: 29277453
Arthritis Rheumatol. 2019 Mar;71(3):468-475
pubmed: 30281202
J Immunother Cancer. 2016 Dec 20;4:94
pubmed: 28031822
J Cancer Res Clin Oncol. 2017 Jul;143(7):1357-1358
pubmed: 28516380
Dermatol Ther. 2016 Sep;29(5):306-308
pubmed: 27357143
J Immunother Cancer. 2018 Jul 16;6(1):73
pubmed: 30012206
Respiration. 2017;94(6):518-521
pubmed: 28910804
Autoimmun Rev. 2018 Oct;17(10):1040-1045
pubmed: 30103042
JAAD Case Rep. 2017 Apr 14;3(3):208-211
pubmed: 28443311
J Immunother Cancer. 2018 Jun 5;6(1):49
pubmed: 29871698
Case Rep Oncol. 2018 Jul 27;11(2):521-526
pubmed: 30186134
J Cutan Pathol. 2018 Jan;45(1):74-77
pubmed: 29028121
J Med Case Rep. 2018 Feb 26;12(1):48
pubmed: 29478412
Autoimmun Rev. 2018 Mar;17(3):284-289
pubmed: 29341936
Cancer Immunol Immunother. 2018 Feb;67(2):175-182
pubmed: 29018908
J Neurooncol. 2018 May;137(3):601-609
pubmed: 29332184
Ann Oncol. 2016 Jun;27(6):1178-1179
pubmed: 27091806
J Oncol Pharm Pract. 2019 Jul;25(5):1282-1284
pubmed: 30249155
Curr Rheumatol Rep. 2019 Feb 21;21(4):10
pubmed: 30790071
Neurology. 2018 Sep 4;91(10):e985-e994
pubmed: 30089619
Cancer Immunol Res. 2016 Mar;4(3):175-8
pubmed: 26822024
Yakugaku Zasshi. 2019;139(3):491-495
pubmed: 30828027
Ann Rheum Dis. 2017 Oct;76(10):1747-1750
pubmed: 28600350
Melanoma Res. 2019 Aug;29(4):435-440
pubmed: 30855529
Expert Opin Drug Saf. 2017 Nov;16(11):1255-1271
pubmed: 28854831
J Immunother Cancer. 2018 Jul 31;6(1):77
pubmed: 30064495
JAAD Case Rep. 2018 Aug 11;4(7):675-677
pubmed: 30112452
Joint Bone Spine. 2017 Mar;84(2):233-234
pubmed: 27133763
Intern Med. 2018 Aug 1;57(15):2217-2221
pubmed: 29526968
Ann Rheum Dis. 2019 Aug;78(8):e82
pubmed: 29936437
J Cutan Pathol. 2018 Aug;45(8):615-618
pubmed: 29740855
J Immunother Cancer. 2018 Feb 12;6(1):14
pubmed: 29433571
Australas J Dermatol. 2018 May;59(2):e152-e154
pubmed: 28726325
Melanoma Res. 2019 Apr;29(2):212-215
pubmed: 30489484
Int J Rheum Dis. 2017 Sep;20(9):1277-1285
pubmed: 28480561
Ann Rheum Dis. 2019 Jul;78(7):e70
pubmed: 29760158
Arthritis Care Res (Hoboken). 2017 Nov;69(11):1751-1763
pubmed: 27998041
Rheum Dis Clin North Am. 2017 Feb;43(1):65-78
pubmed: 27890174
Front Oncol. 2018 Sep 26;8:409
pubmed: 30319973
Ann Rheum Dis. 2019 Nov;78(11):e129
pubmed: 30242031
J Immunother. 2017 Sep;40(7):282-285
pubmed: 28604554
RMD Open. 2018 Aug 17;4(2):e000714
pubmed: 30167328
BMJ Case Rep. 2017 Dec 2;2017:
pubmed: 29197854
J Immunother. 2017 May;40(4):129-131
pubmed: 28267050
Expert Rev Anticancer Ther. 2017 Apr;17(4):387-394
pubmed: 28277102
Ann Rheum Dis. 2019 Jun;78(6):860-862
pubmed: 30659050
J Immunother. 2017 Oct;40(8):312-314
pubmed: 28614096
Am J Otolaryngol. 2018 Sep - Oct;39(5):642-645
pubmed: 29903623
Respir Med Case Rep. 2018 Mar 02;23:182-187
pubmed: 29719813
J Immunother Cancer. 2019 Jan 6;7(1):2
pubmed: 30612580
JAAD Case Rep. 2016 Jul 27;2(4):290-3
pubmed: 27504482
Cancer Immunol Res. 2015 Oct;3(10):1185-92
pubmed: 26100356
J Immunother. 2018 May;41(4):208-211
pubmed: 29200081
Ann Rheum Dis. 2019 Jul;78(7):e67
pubmed: 29858173
J Clin Rheumatol. 2017 Jun;23(4):235
pubmed: 28538282
N Engl J Med. 2009 Jul 9;361(2):211-2
pubmed: 19587352
Neurology. 2017 Sep 12;89(11):1127-1134
pubmed: 28821685
Intern Med J. 2018 Dec;48(12):1550-1552
pubmed: 30517989
Clin Rheumatol. 2018 Sep;37(9):2579-2584
pubmed: 29923081
Lancet Oncol. 2018 Dec;19(12):1579-1589
pubmed: 30442497
Oncologist. 2019 Apr;24(4):435-443
pubmed: 30482825
Br J Dermatol. 2017 Apr;176(4):1060-1063
pubmed: 27291635