Potential application of novel liquid crystal nanoparticles of isostearyl glyceryl ether for transdermal delivery of 4-biphenyl acetic acid.
Administration, Cutaneous
Animals
Castor Oil
/ administration & dosage
Drug Delivery Systems
Drug Liberation
Glyceryl Ethers
/ administration & dosage
Humans
In Vitro Techniques
Liquid Crystals
/ chemistry
Male
Mice, Hairless
Nanoparticles
/ administration & dosage
Phenylacetates
/ administration & dosage
Skin
/ metabolism
Skin Absorption
Skin Irritancy Tests
Absorption mechanism
Isostearyl glyceryl ether
Liquid crystal
Percutaneous absorption
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
15 Feb 2020
15 Feb 2020
Historique:
received:
16
09
2019
revised:
14
11
2019
accepted:
02
12
2019
pubmed:
10
12
2019
medline:
3
11
2020
entrez:
10
12
2019
Statut:
ppublish
Résumé
Novel liquid crystal nanoparticles (LCNs) composed of isostearyl glyceryl ether (GE-IS) and ethoxylated hydrogenated castor oil (HCO-60) were developed for the enhanced transdermal delivery of 4-biphenyl acetic acid (BAA). The physical properties and pharmaceutical properties of the LCNs were measured. The interaction between the intercellular lipid model of the stratum corneum and the LCNs was observed to elucidate the skin permeation mechanism. In the formulation, the LCNs form niosomes with mean particles sizes of 180-300 nm. The skin absorption mechanisms of LCNs are different, depending upon the application and buffer concentration. The LCNs composed of GE-IS and HCO-60 are attractive tools for use as transdermal drug delivery systems carriers for medicines and cosmetics, due to their high efficiency and safety.
Identifiants
pubmed: 31816353
pii: S0378-5173(19)30980-9
doi: 10.1016/j.ijpharm.2019.118935
pii:
doi:
Substances chimiques
Glyceryl Ethers
0
Phenylacetates
0
biphenylylacetic acid
51317-25-0
Castor Oil
8001-79-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
118935Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.