The influence of metformin on IGF-1 levels in humans: A systematic review and meta-analysis.

Child Dose-Response Relationship, Drug Humans Hypoglycemic Agents / administration & dosage Insulin-Like Growth Factor I / analysis Metformin / administration & dosage Randomized Controlled Trials as Topic
Biguanidine IGF-1 Insulin-like growth factor I Meta-analysis Metformin

Journal

Pharmacological research
ISSN: 1096-1186
Titre abrégé: Pharmacol Res
Pays: Netherlands
ID NLM: 8907422

Informations de publication

Date de publication:
01 2020
Historique:
received: 23 09 2019
revised: 26 11 2019
accepted: 05 12 2019
pubmed: 10 12 2019
medline: 6 1 2021
entrez: 10 12 2019
Statut: ppublish

Résumé

A meta-analysis is needed to comprehensively consolidate findings from the influence of metformin on IGF-1 levels. The present study was conducted with the objective to accurately evaluate the influence of metformin intake on IGF-1 levels via a meta-analysis of randomized controlled trials. A comprehensive systematic search was carried out in PubMed/MEDLINE, Web of Science, SCOPUS and Embase from inception until June 2019. Weighted mean difference (WMD) with the 95 % CI were applied for estimating the effects of metformin on serum IGF-1 levels. 11 studies involving a total of 569 individuals reported changes in IGF-1 plasma concentrations as an outcome measure. Pooled results demonstrated an overall non-significant decline in IGF-1 following metformin intake (WMD: -8.292 ng/ml, 95 % CI: -20.248, 3.664, p = 0.174) with heterogeneity among (p = 0.000,I We found in children, intervention duration <12 weeks yielded significant reductions in IGF-1, whilst paradoxically, in participants >18 years old, metformin intake significantly increased IGF-1. We suggest that caution be taken when interpreting the findings of this review, particularly given the discordant supplementation practices between children and adults.

Sections du résumé

BACKGROUND
A meta-analysis is needed to comprehensively consolidate findings from the influence of metformin on IGF-1 levels. The present study was conducted with the objective to accurately evaluate the influence of metformin intake on IGF-1 levels via a meta-analysis of randomized controlled trials.
METHODS
A comprehensive systematic search was carried out in PubMed/MEDLINE, Web of Science, SCOPUS and Embase from inception until June 2019. Weighted mean difference (WMD) with the 95 % CI were applied for estimating the effects of metformin on serum IGF-1 levels.
RESULTS
11 studies involving a total of 569 individuals reported changes in IGF-1 plasma concentrations as an outcome measure. Pooled results demonstrated an overall non-significant decline in IGF-1 following metformin intake (WMD: -8.292 ng/ml, 95 % CI: -20.248, 3.664, p = 0.174) with heterogeneity among (p = 0.000,I
CONCLUSION
We found in children, intervention duration <12 weeks yielded significant reductions in IGF-1, whilst paradoxically, in participants >18 years old, metformin intake significantly increased IGF-1. We suggest that caution be taken when interpreting the findings of this review, particularly given the discordant supplementation practices between children and adults.

Identifiants

DOI: 10.1016/j.phrs.2019.104588 PMID: 31816435
pubmed: 31816435
pii: S1043-6618(19)32081-X
doi: 10.1016/j.phrs.2019.104588
pii:
doi:

Substances chimiques

Hypoglycemic Agents 0
IGF1 protein, human 0
Insulin-Like Growth Factor I 67763-96-6
Metformin 9100L32L2N

Types de publication

Journal Article Meta-Analysis Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

104588

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Xiaodong Yang (X)

Department of General Medicine, Zhumadian Central Hospital, Zhumadian, He'nan, 463000, China.

Hamed Kord-Varkaneh (H)

Department of Clinical Nutrition and Dietetics, Student Research Committee, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Sam Talaei (S)

School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Cain C T Clark (CCT)

Centre for Sport, Exercise and Life Sciences, Coventry University, Coventry, CV15FB, UK.

Fernando Zanghelini (F)

Postgraduate Program in Therapeutic Innovation, Federal University of Pernambuco, Pernambuco, Brazil.

Shing Cheng Tan (SC)

UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

Meysam Zarezadeh (M)

Department of Clinical Nutrition, Student Research Committee, Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

Seyed Mohammad Mousavi (SM)

Department of Community Nutrition, Students' Scientific Research Center (SSRC), School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.

Jamal Rahmani (J)

Department of Community Nutrition, Students' Scientific Research Center (SSRC), School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.

Yong Zhang (Y)

School of Public Health and Health Management, Chongqing Medical University, Chongqing, 400016, China. Electronic address: zhangyongcq@live.cn.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › The influence of metformin on IGF-1 levels in...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › The influence of metformin on IGF-1 levels in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The influence of metformin on IGF-1 levels in...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › The influence of metformin on IGF-1 levels in...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Somatomédines › Facteur de croissance IGF-I › The influence of metformin on IGF-1 levels in...
questionsmedicales.fr › Composés chimiques organiques › Amidines › Guanidines › Biguanides › Metformine › The influence of metformin on IGF-1 levels in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Essais cliniques contrôlés comme sujet › Essais contrôlés randomisés comme sujet › The influence of metformin on IGF-1 levels in...