Combing the Cancer Genome for Novel Kinase Drivers and New Therapeutic Targets.
driver mutation
kinases
oncogenes
precision therapies
signal transduction
therapy resistance
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
07 Dec 2019
07 Dec 2019
Historique:
received:
31
10
2019
revised:
04
12
2019
accepted:
05
12
2019
entrez:
11
12
2019
pubmed:
11
12
2019
medline:
11
12
2019
Statut:
epublish
Résumé
Protein kinases are critical regulators of signaling cascades that control cellular proliferation, growth, survival, metabolism, migration, and invasion. Deregulation of kinase activity can lead to aberrant regulation of biological processes and to the onset of diseases, including cancer. In this review, we focus on oncogenic kinases and the signaling pathways they regulate that underpin tumor development. We highlight genomic biomarker-based precision medicine intervention strategies that match kinase inhibitors alone or in combination to mutationally activated kinase drivers, as well as progress towards implementation of these treatment strategies in the clinic. We also discuss the challenges for identification of novel protein kinase cancer drivers in the genomic era.
Identifiants
pubmed: 31817861
pii: cancers11121972
doi: 10.3390/cancers11121972
pmc: PMC6966563
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : NIH HHS
ID : ZIABC011691
Pays : United States
Références
N Engl J Med. 2014 Nov 20;371(21):1963-71
pubmed: 25264305
Br J Cancer. 2018 Jan;118(1):3-8
pubmed: 29235562
Sci Rep. 2017 Apr 4;7(1):641
pubmed: 28377632
Cell. 1979 Dec;18(4):915-24
pubmed: 229972
Nat Biotechnol. 2017 Aug 8;35(8):696-698
pubmed: 28787411
Dev Cell. 2010 Jun 15;18(6):884-901
pubmed: 20627072
Nature. 2007 Mar 8;446(7132):153-8
pubmed: 17344846
Science. 2001 Aug 3;293(5531):876-80
pubmed: 11423618
Int J Cancer. 2019 Jun 1;144(11):2677-2682
pubmed: 30255937
Cell. 2012 Apr 13;149(2):274-93
pubmed: 22500797
Nat Rev Cancer. 2012 Mar 22;12(4):237-51
pubmed: 22437869
J Thorac Dis. 2010 Mar;2(1):48-51
pubmed: 22263017
Cancer Res. 2016 Jan 15;76(2):227-38
pubmed: 26637667
Lab Invest. 2018 Feb;98(2):233-247
pubmed: 29058706
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Int J Mol Sci. 2018 Jul 20;19(7):null
pubmed: 30037003
Cell. 2017 Feb 9;168(4):613-628
pubmed: 28187284
Science. 2016 May 20;352(6288):aad3018
pubmed: 27199435
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1311-5
pubmed: 6246487
Nat Rev Drug Discov. 2017 Feb;16(2):101-114
pubmed: 27885283
Nat Rev Drug Discov. 2019 Mar 6;:null
pubmed: 30936511
Sci Transl Med. 2015 Mar 18;7(279):279ra41
pubmed: 25787767
Nat Commun. 2014 May 22;5:3901
pubmed: 24849047
Proc Natl Acad Sci U S A. 1978 Apr;75(4):2021-4
pubmed: 205879
Cancer Cell. 2002 Aug;2(2):117-25
pubmed: 12204532
Cancer Cell. 2014 Feb 10;25(2):139-51
pubmed: 24525231
Nat Med. 2019 Jun;25(6):936-940
pubmed: 31171879
Nature. 2016 Nov 17;539(7629):443-447
pubmed: 27828943
Nature. 1983 Jun 2-8;303(5916):435-9
pubmed: 6304524
Nat Rev Cancer. 2007 May;7(5):345-56
pubmed: 17457302
Science. 2013 Mar 29;339(6127):1546-58
pubmed: 23539594
Cold Spring Harb Perspect Med. 2019 Jan 2;9(1):
pubmed: 29358316
Cancer Cell. 2014 Sep 8;26(3):402-413
pubmed: 25155755
Pigment Cell Melanoma Res. 2016 Sep;29(5):493-5
pubmed: 27399172
Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12426-31
pubmed: 23836671
Cancer Discov. 2016 Mar;6(3):270-85
pubmed: 26715645
J Clin Oncol. 2011 Aug 1;29(22):3085-96
pubmed: 21383288
Cell Cycle. 2014;13(4):528-37
pubmed: 24299711
Nat Med. 2016 Aug;22(8):851-60
pubmed: 27376576
Nature. 2011 Nov 23;480(7377):387-90
pubmed: 22113612
Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):E4623-31
pubmed: 25319261
Oncoimmunology. 2018 May 7;7(8):e1458810
pubmed: 30221055
Pharmacol Res. 2019 Jun;144:19-50
pubmed: 30877063
Clin Cancer Res. 2018 Jun 15;24(12):2828-2843
pubmed: 29599409
N Engl J Med. 2011 Jun 30;364(26):2507-16
pubmed: 21639808
Cell. 1979 Dec;18(4):935-46
pubmed: 229974
Proc Natl Acad Sci U S A. 2009 May 26;106(21):8695-700
pubmed: 19433805
Exp Mol Med. 2018 Dec 13;50(12):165
pubmed: 30546008
Nat Med. 2013 Oct;19(10):1264-72
pubmed: 24056773
Cell. 2015 Apr 9;161(2):205-14
pubmed: 25860605
Sci Signal. 2017 Dec 05;10(508):null
pubmed: 29208683
Nat Med. 2012 Feb 12;18(3):382-4
pubmed: 22327622
Nature. 2016 Nov 17;539(7629):437-442
pubmed: 27642729
Cold Spring Harb Symp Quant Biol. 2016;81:257-267
pubmed: 28057848
Nature. 2002 Jun 27;417(6892):949-54
pubmed: 12068308
Sci Signal. 2010 Nov 23;3(149):ra84
pubmed: 21098728
N Engl J Med. 2015 Aug 20;373(8):726-36
pubmed: 26287849
Cancer Res. 2019 Feb 15;79(4):689-698
pubmed: 30718357
Nature. 2017 Jul 27;547(7664):413-418
pubmed: 28723893
Nature. 2016 Jun 30;534(7609):647-51
pubmed: 27338794
Cancer Cell. 2018 Mar 12;33(3):450-462.e10
pubmed: 29533785
JAMA Netw Open. 2019 May 3;2(5):e192535
pubmed: 31050774
J Am Chem Soc. 2018 Dec 12;140(49):17019-17026
pubmed: 30444612
Nature. 2017 Oct 12;550(7675):270-274
pubmed: 28976960
Oncogene. 2017 Jan 26;36(4):534-545
pubmed: 27321186
N Engl J Med. 2005 Feb 24;352(8):786-92
pubmed: 15728811
NPJ Genom Med. 2018 Jun 20;3:15
pubmed: 29951225
Biochim Biophys Acta. 1956 Apr;20(1):150-7
pubmed: 13315361
Nature. 2010 Dec 16;468(7326):968-72
pubmed: 21107320
Nat Rev Drug Discov. 2012 Nov;11(11):873-86
pubmed: 23060265
Nat Rev Drug Discov. 2011 Oct 31;10(11):868-80
pubmed: 22037041
Nat Commun. 2014 Sep 10;5:4846
pubmed: 25204415
Cancer Discov. 2018 Feb;8(2):216-233
pubmed: 29101163
Exp Mol Med. 2018 Aug 7;50(8):99
pubmed: 30089794
Cell. 2010 Jan 22;140(2):209-21
pubmed: 20141835
J Clin Oncol. 2012 Jan 20;30(3):316-21
pubmed: 22067401
Cell Rep. 2018 Feb 13;22(7):1889-1902
pubmed: 29444439
Cell. 2017 Apr 20;169(3):381-405
pubmed: 28431241
Nature. 2017 Aug 24;548(7668):471-475
pubmed: 28813415
Mol Cell Biol. 2015 Jan;35(1):264-76
pubmed: 25348715
Cancer Discov. 2015 Nov;5(11):1155-63
pubmed: 26286086
EMBO Mol Med. 2016 Jan 12;8(2):105-16
pubmed: 26758680
Nature. 2010 Mar 18;464(7287):431-5
pubmed: 20130576
Nature. 2007 Aug 2;448(7153):561-6
pubmed: 17625570
Cell. 2017 Feb 9;168(4):584-599
pubmed: 28187282
Methods Enzymol. 2014;548:117-46
pubmed: 25399644
Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4508-4517
pubmed: 30709910
Ann Oncol. 2016 Oct;27(10):1959-65
pubmed: 27502704
Mol Cancer. 2018 Feb 19;17(1):58
pubmed: 29455648
J Am Chem Soc. 2018 Dec 5;140(48):16428-16432
pubmed: 30427680
Cell. 1979 Dec;18(4):925-33
pubmed: 229973
Cancer Cell. 2012 Nov 13;22(5):668-82
pubmed: 23153539
Cancer Res. 2019 Sep 15;79(18):4744-4753
pubmed: 31311809
Nat Chem Biol. 2010 Mar;6(3):166-169
pubmed: 20154661
Genes Dev. 2014 Aug 15;28(16):1800-14
pubmed: 25128497
Cancer Sci. 2007 Aug;98(8):1275-80
pubmed: 17498200
Nat Rev Drug Discov. 2019 Jul;18(7):501-526
pubmed: 30850748
J Biol Chem. 1955 Sep;216(1):121-32
pubmed: 13252012
Cancer Res. 2018 Jan 1;78(1):15-29
pubmed: 29254998
N Engl J Med. 2004 May 20;350(21):2129-39
pubmed: 15118073
Cancer Cell. 2007 Mar;11(3):217-27
pubmed: 17349580
Nat Commun. 2018 May 22;9(1):2024
pubmed: 29789628
N Engl J Med. 2012 Jan 19;366(3):207-15
pubmed: 22256804
Trends Cancer. 2016 May;2(5):263-276
pubmed: 28741512
Cancer Cell. 2015 Sep 14;28(3):370-83
pubmed: 26343582
N Engl J Med. 2001 Apr 5;344(14):1031-7
pubmed: 11287972
Cell. 2015 Sep 24;163(1):160-73
pubmed: 26406376
Cell. 2018 Dec 13;175(7):1972-1988.e16
pubmed: 30550791
Eur J Cancer. 2010 Jul;46(10):1773-80
pubmed: 20418096
Cancer Res. 2017 Sep 15;77(18):4961-4972
pubmed: 28760853
Nat Med. 2017 Sep 8;23(9):1028-1035
pubmed: 28886003
Nat Med. 2018 May;24(4):512-517
pubmed: 29505033
Adv Biol Regul. 2016 Jan;60:47-63
pubmed: 26754874
Cell. 2016 May 5;165(4):910-20
pubmed: 27087446
Cancer Discov. 2018 Feb;8(2):174-183
pubmed: 29247016
Cancer Discov. 2016 Jul;6(7):714-26
pubmed: 27147599
Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):7877-82
pubmed: 26130799
Cancer Cell. 2011 Jan 18;19(1):58-71
pubmed: 21215704