John Brognard

Affiliations

Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.

Publications (13)

New Therapeutic Opportunities for the Treatment of Squamous Cell Carcinomas: A Focus on Novel Driver Kinases.

International journal of molecular sciences

Avec: Ryan Bensen , John Brognard

Orange is the new black: Kinases are the new master regulators of tumor suppression.

IUBMB life

Avec: Elvira An , John Brognard

Degraders: The Ultimate Weapon Against Amplified Driver Kinases in Cancer.

Molecular pharmacology

Avec: Pedro Torres-Ayuso , John Brognard

TNIK inhibition sensitizes TNIK-overexpressing lung squamous cell carcinoma to radiotherapy.

Molecular cancer therapeutics

Avec: Triet Nguyen , Francesca Anna Carrieri , Nick Connis , Audrey Lafargue , Jinhee Chang , Aaron Chan , Amol C Shetty , Yang Song , Tung Hoang , Shreya Jagtap , Dipanwita Dutta Chowdhury , Muhammad Ajmal Khan , Kathleen L Gabrielson , Mohammad Rezaee , Pedro Torres-Ayuso , John Brognard , Christine L Hann , Phuoc T Tran

The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby activates ERK and JNK kinases and increases viability of KRAS-mutant lung cancer cells.

The Journal of biological chemistry

Avec: Van T Hoang , Katherine Nyswaner , Pedro Torres-Ayuso , John Brognard

PIM1 targeted degradation prevents the emergence of chemoresistance in prostate cancer.

Cell chemical biology

Avec: Pedro Torres-Ayuso , Meghri Katerji , Dawid Mehlich , Sophia A Lookingbill , Venkata R Sabbasani , Hope Liou , Andrea L Casillas , Shailender S Chauhan , Remigiusz Serwa , Maxine R Rubin , Anna A Marusiak , Rolf E Swenson , Noel A Warfel , John Brognard

TNIK Inhibition Sensitizes TNIK-Overexpressing Lung Squamous Cell Carcinoma to Radiotherapy.

Molecular cancer therapeutics

Avec: Triet Nguyen , Francesca A Carrieri , Nick Connis , Audrey Lafargue , Jinhee Chang , Aaron Chan , Amol C Shetty , Yang Song , Tung Hoang , Shreya Jagtap , Dipanwita D Chowdhury , Muhammad A Khan , Kathleen L Gabrielson , Mohammad Rezaee , Pedro Torres-Ayuso , John Brognard , Christine L Hann , Phuoc T Tran

Combing the Cancer Genome for Novel Kinase Drivers and New Therapeutic Targets.

Cancers

Avec: Pedro Torres-Ayuso , John Brognard

Upregulation of MLK4 promotes migratory and invasive potential of breast cancer cells.

Oncogene

Avec: Anna A Marusiak , Monika K Prelowska , Dawid Mehlich , Michal Lazniewski , Klaudia Kaminska , Adam Gorczynski , Aleksandra Korwat , Olga Sokolowska , Hanna Kedzierska , Jakub Golab , Wojciech Biernat , Dariusz Plewczynski , John Brognard , Dominika Nowis

TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin.

Cancer discovery

Avec: Pedro Torres-Ayuso , Elvira An , Katherine M Nyswaner , Ryan C Bensen , Daniel A Ritt , Suzanne I Specht , Sudipto Das , Thorkell Andresson , Raul E Cachau , Roger J Liang , Amy L Ries , Christina M Robinson , Simone Difilippantonio , Brad Gouker , Laura Bassel , Baktiar O Karim , Chad J Miller , Benjamin E Turk , Deborah K Morrison , John Brognard

Serine-linked PARP1 auto-modification controls PARP inhibitor response.

Nature communications

Avec: Evgeniia Prokhorova , Florian Zobel , Rebecca Smith , Siham Zentout , Ian Gibbs-Seymour , Kira Schützenhofer , Alessandra Peters , Joséphine Groslambert , Valentina Zorzini , Thomas Agnew , John Brognard , Michael L Nielsen , Dragana Ahel , Sébastien Huet , Marcin J Suskiewicz , Ivan Ahel

The SRC family kinase inhibitor NXP900 demonstrates potent anti-tumor activity in squamous cell carcinomas.

The Journal of biological chemistry

Avec: Sweta Dash , Sabrina Hanson , Ben King , Katherine Nyswaner , Kelcie Foss , Noelle Tesi , Mungo J B Harvey , Saúl A Navarro-Marchal , Allison Woods , Enrique Poradosu , Asier Unciti-Broceta , Neil O Carragher , John Brognard

Selective Degradation of MLK3 by a Novel CEP1347-VHL-02 PROTAC Compound Limits the Oncogenic Potential of TNBC.

Journal of medicinal chemistry

Avec: Kamila Karpińska , Dawid Mehlich , Venkata R Sabbasani , Michał Łomiak , Pedro Torres-Ayuso , Katarzyna Wróbel , Vi Nguyen-Phuong Truong , Remigiusz Serwa , Rolf E Swenson , John Brognard , Anna A Marusiak

Réseau de co-auteurs

Pedro Torres-Ayuso 8 collaborations

Dawid Mehlich 3 collaborations

Anna A Marusiak 3 collaborations

Elvira An 2 collaborations

Triet Nguyen 2 collaborations

Nick Connis 2 collaborations

Audrey Lafargue 2 collaborations

Jinhee Chang 2 collaborations

Aaron Chan 2 collaborations

Amol C Shetty 2 collaborations

Yang Song 2 collaborations

Tung Hoang 2 collaborations

Shreya Jagtap 2 collaborations

Kathleen L Gabrielson 2 collaborations

Mohammad Rezaee 2 collaborations

Christine L Hann 2 collaborations

Phuoc T Tran 2 collaborations

Katherine Nyswaner 2 collaborations

Venkata R Sabbasani 2 collaborations

Remigiusz Serwa 2 collaborations

Rolf E Swenson 2 collaborations

Ryan Bensen 1 collaboration

Francesca Anna Carrieri 1 collaboration

Dipanwita Dutta Chowdhury 1 collaboration

Muhammad Ajmal Khan 1 collaboration

Van T Hoang 1 collaboration

Meghri Katerji 1 collaboration

Sophia A Lookingbill 1 collaboration

Hope Liou 1 collaboration

Andrea L Casillas 1 collaboration

Shailender S Chauhan 1 collaboration

Maxine R Rubin 1 collaboration

Noel A Warfel 1 collaboration

Francesca A Carrieri 1 collaboration

Dipanwita D Chowdhury 1 collaboration

Muhammad A Khan 1 collaboration

Monika K Prelowska 1 collaboration

Michal Lazniewski 1 collaboration

Klaudia Kaminska 1 collaboration

Adam Gorczynski 1 collaboration

Aleksandra Korwat 1 collaboration

Olga Sokolowska 1 collaboration

Hanna Kedzierska 1 collaboration

Jakub Golab 1 collaboration

Wojciech Biernat 1 collaboration

Dariusz Plewczynski 1 collaboration

Dominika Nowis 1 collaboration

Katherine M Nyswaner 1 collaboration

Ryan C Bensen 1 collaboration

Daniel A Ritt 1 collaboration

Suzanne I Specht 1 collaboration

Sudipto Das 1 collaboration

Thorkell Andresson 1 collaboration

Raul E Cachau 1 collaboration

Roger J Liang 1 collaboration

Amy L Ries 1 collaboration

Christina M Robinson 1 collaboration

Simone Difilippantonio 1 collaboration

Brad Gouker 1 collaboration

Laura Bassel 1 collaboration

Baktiar O Karim 1 collaboration

Chad J Miller 1 collaboration

Benjamin E Turk 1 collaboration

Deborah K Morrison 1 collaboration

Evgeniia Prokhorova 1 collaboration

Florian Zobel 1 collaboration

Rebecca Smith 1 collaboration

Siham Zentout 1 collaboration

Ian Gibbs-Seymour 1 collaboration

Kira Schützenhofer 1 collaboration

Alessandra Peters 1 collaboration

Joséphine Groslambert 1 collaboration

Valentina Zorzini 1 collaboration

Thomas Agnew 1 collaboration

Michael L Nielsen 1 collaboration

Dragana Ahel 1 collaboration

Sébastien Huet 1 collaboration

Marcin J Suskiewicz 1 collaboration

Ivan Ahel 1 collaboration

Sweta Dash 1 collaboration

Sabrina Hanson 1 collaboration

Ben King 1 collaboration

Kelcie Foss 1 collaboration

Noelle Tesi 1 collaboration

Mungo J B Harvey 1 collaboration

Saúl A Navarro-Marchal 1 collaboration

Allison Woods 1 collaboration

Enrique Poradosu 1 collaboration

Asier Unciti-Broceta 1 collaboration

Neil O Carragher 1 collaboration

Kamila Karpińska 1 collaboration

Michał Łomiak 1 collaboration

Katarzyna Wróbel 1 collaboration

Vi Nguyen-Phuong Truong 1 collaboration