The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby activates ERK and JNK kinases and increases viability of KRAS-mutant lung cancer cells.
Cell Line, Tumor
Cell Survival
/ drug effects
Drug Resistance, Neoplasm
Humans
JNK Mitogen-Activated Protein Kinases
/ metabolism
Lung Neoplasms
/ metabolism
MAP Kinase Kinase Kinases
/ antagonists & inhibitors
MAP Kinase Signaling System
Mitogen-Activated Protein Kinase 1
/ metabolism
Mitogen-Activated Protein Kinase 3
/ metabolism
Mitogen-Activated Protein Kinase Kinases
/ antagonists & inhibitors
Phosphorylation
/ drug effects
Protein Kinase Inhibitors
/ pharmacology
Proto-Oncogene Mas
Proto-Oncogene Proteins c-raf
/ antagonists & inhibitors
Proto-Oncogene Proteins p21(ras)
/ genetics
RNA Interference
RNA, Small Interfering
/ metabolism
GTPase Kras (KRAS)
YSK4
c-Jun N-terminal kinase (JNK)
cell proliferation
extracellular-signal-regulated kinase (ERK)
kinase signaling
kinome
lung cancer
mitogen-activated protein kinase kinase kinase 19 (MAP3K19)
oncogene
protein kinase
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
19 06 2020
19 06 2020
Historique:
received:
18
12
2019
revised:
27
04
2020
pubmed:
3
5
2020
medline:
6
1
2021
entrez:
3
5
2020
Statut:
ppublish
Résumé
Identifying additional mitogen-activated protein kinase (MAPK) pathway regulators is invaluable in aiding our understanding of the complex signaling networks that regulate cellular processes, including cell proliferation and survival. Here, using
Identifiants
pubmed: 32358059
pii: S0021-9258(17)49240-4
doi: 10.1074/jbc.RA119.012365
pmc: PMC7307187
doi:
Substances chimiques
MAS1 protein, human
0
Protein Kinase Inhibitors
0
Proto-Oncogene Mas
0
RNA, Small Interfering
0
Proto-Oncogene Proteins c-raf
EC 2.7.11.1
JNK Mitogen-Activated Protein Kinases
EC 2.7.11.24
Mitogen-Activated Protein Kinase 1
EC 2.7.11.24
Mitogen-Activated Protein Kinase 3
EC 2.7.11.24
MAP Kinase Kinase Kinases
EC 2.7.11.25
MAP3K19 protein, human
EC 2.7.11.25
Mitogen-Activated Protein Kinase Kinases
EC 2.7.12.2
Proto-Oncogene Proteins p21(ras)
EC 3.6.5.2
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
8470-8479Subventions
Organisme : Intramural NIH HHS
ID : ZIA BC011691
Pays : United States
Déclaration de conflit d'intérêts
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
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