Ivan Ahel

Affiliations

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK. ivan.ahel@path.ox.ac.uk jfraser@fraserlab.com bshoichet@gmail.com frank.von-delft@diamond.ac.uk.

Publications (65)

Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking.

Science advances

Avec: Marion Schuller , Galen J Correy , Stefan Gahbauer , Daren Fearon , Taiasean Wu , Roberto Efraín Díaz , Iris D Young , Luan Carvalho Martins , Dominique H Smith , Ursula Schulze-Gahmen , Tristan W Owens , Ishan Deshpande , Gregory E Merz , Aye C Thwin , Justin T Biel , Jessica K Peters , Michelle Moritz , Nadia Herrera , Huong T Kratochvil , Auteur inconnu , Anthony Aimon , James M Bennett , Jose Brandao Neto , Aina E Cohen , Alexandre Dias , Alice Douangamath , Louise Dunnett , Oleg Fedorov , Matteo P Ferla , Martin R Fuchs , Tyler J Gorrie-Stone , James M Holton , Michael G Johnson , Tobias Krojer , George Meigs , Ailsa J Powell , Johannes Gregor Matthias Rack , Victor L Rangel , Silvia Russi , Rachael E Skyner , Clyde A Smith , Alexei S Soares , Jennifer L Wierman , Kang Zhu , Peter O'Brien , Natalia Jura , Alan Ashworth , John J Irwin , Michael C Thompson , Jason E Gestwicki , Frank von Delft , Brian K Shoichet , James S Fraser , Ivan Ahel

Exploring protein hotspots by optimized fragment pharmacophores.

Nature communications

Avec: Dávid Bajusz , Warren S Wade , Grzegorz Satała , Andrzej J Bojarski , Janez Ilaš , Jessica Ebner , Florian Grebien , Henrietta Papp , Ferenc Jakab , Alice Douangamath , Daren Fearon , Frank von Delft , Marion Schuller , Ivan Ahel , Amanda Wakefield , Sándor Vajda , János Gerencsér , Péter Pallai , György M Keserű

Serine-linked PARP1 auto-modification controls PARP inhibitor response.

Nature communications

Avec: Evgeniia Prokhorova , Florian Zobel , Rebecca Smith , Siham Zentout , Ian Gibbs-Seymour , Kira Schützenhofer , Alessandra Peters , Joséphine Groslambert , Valentina Zorzini , Thomas Agnew , John Brognard , Michael L Nielsen , Dragana Ahel , Sébastien Huet , Marcin J Suskiewicz , Ivan Ahel

Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal.

Nature communications

Avec: Johannes Gregor Matthias Rack , Qiang Liu , Valentina Zorzini , Jim Voorneveld , Antonio Ariza , Kourosh Honarmand Ebrahimi , Julia M Reber , Sarah C Krassnig , Dragana Ahel , Gijsbert A van der Marel , Aswin Mangerich , James S O McCullagh , Dmitri V Filippov , Ivan Ahel

Mimetics of ADP-Ribosylated Histidine through Copper(I)-Catalyzed Click Chemistry.

Organic letters

Avec: Hugo Minnee , Johannes G M Rack , Gijsbert A van der Marel , Herman S Overkleeft , Jeroen D C Codée , Ivan Ahel , Dmitri V Filippov

Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 Macrodomain of SARS-CoV-2.

bioRxiv : the preprint server for biology

Avec: Stefan Gahbauer , Galen J Correy , Marion Schuller , Matteo P Ferla , Yagmur Umay Doruk , Moira Rachman , Taiasean Wu , Morgan Diolaiti , Siyi Wang , R Jeffrey Neitz , Daren Fearon , Dmytro Radchenko , Yurii Moroz , John J Irwin , Adam R Renslo , Jenny C Taylor , Jason E Gestwicki , Frank von Delft , Alan Ashworth , Ivan Ahel , Brian K Shoichet , James S Fraser

DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates.

Science advances

Avec: Kang Zhu , Marcin J Suskiewicz , Andrea Hloušek-Kasun , Hervé Meudal , Andreja Mikoč , Vincent Aucagne , Dragana Ahel , Ivan Ahel

Molecular basis for the reversible ADP-ribosylation of guanosine bases.

Molecular cell

Avec: Marion Schuller , Roberto Raggiaschi , Petra Mikolcevic , Johannes G M Rack , Antonio Ariza , YuGeng Zhang , Raphael Ledermann , Christoph Tang , Andreja Mikoc , Ivan Ahel

Legionella metaeffector MavL reverses ubiquitin ADP-ribosylation via a conserved arginine-specific macrodomain.

Nature communications

Avec: Zhengrui Zhang , Jiaqi Fu , Johannes Gregor Matthias Rack , Chuang Li , Jim Voorneveld , Dmitri V Filippov , Ivan Ahel , Zhao-Qing Luo , Chittaranjan Das

ADP-ribosylation signalling and human disease.

Open biology

Avec: Luca Palazzo , Petra Mikolčević , Andreja Mikoč , Ivan Ahel

NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair.

Cell reports

Avec: Deeksha Munnur , Joanna Somers , George Skalka , Ria Weston , Rebekah Jukes-Jones , Mohammed Bhogadia , Cyril Dominguez , Kelvin Cain , Ivan Ahel , Michal Malewicz

(ADP-ribosyl)hydrolases: structure, function, and biology.

Genes & development

Avec: Johannes Gregor Matthias Rack , Luca Palazzo , Ivan Ahel

Serine ADP-ribosylation in DNA-damage response regulation.

Current opinion in genetics & development

Avec: Luca Palazzo , Marcin J Suskiewicz , Ivan Ahel

The Making and Breaking of Serine-ADP-Ribosylation in the DNA Damage Response.

Frontiers in cell and developmental biology

Avec: Kira Schützenhofer , Johannes Gregor Matthias Rack , Ivan Ahel

Molecular Tools for the Study of ADP-Ribosylation: A Unified and Versatile Method to Synthesise Native Mono-ADP-Ribosylated Peptides.

Chemistry (Weinheim an der Bergstrasse, Germany)

Avec: Jim Voorneveld , Johannes Gregor Matthias Rack , Luke van Gijlswijk , Nico J Meeuwenoord , Qiang Liu , Herman S Overkleeft , Gijsbert A van der Marel , Ivan Ahel , Dmitri V Filippov

Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD.

Molecular cell

Avec: Graeme Hewitt , Valerie Borel , Sandra Segura-Bayona , Tohru Takaki , Phil Ruis , Roberto Bellelli , Laura C Lehmann , Lucia Sommerova , Aleksandra Vancevska , Antonia Tomas-Loba , Kang Zhu , Christopher Cooper , Kasper Fugger , Harshil Patel , Robert Goldstone , Deborah Schneider-Luftman , Ellie Herbert , Gordon Stamp , Rachel Brough , Stephen Pettitt , Christopher J Lord , Stephen C West , Ivan Ahel , Dragana Ahel , J Ross Chapman , Sebastian Deindl , Simon J Boulton

ADP-ribosylation systems in bacteria and viruses.

Computational and structural biotechnology journal

Avec: Petra Mikolčević , Andrea Hloušek-Kasun , Ivan Ahel , Andreja Mikoč

Bridging of DNA breaks activates PARP2-HPF1 to modify chromatin.

Nature

Avec: Silvija Bilokapic , Marcin J Suskiewicz , Ivan Ahel , Mario Halic

ADP-ribosylation of DNA and RNA.

DNA repair

Avec: Joséphine Groslambert , Evgeniia Prokhorova , Ivan Ahel

Solid-Phase Synthesis and Biological Evaluation of Peptides ADP-Ribosylated at Histidine.

Angewandte Chemie (Weinheim an der Bergstrasse, Germany)

Avec: Hugo Minnee , Johannes G M Rack , Gijsbert A van der Marel , Herman S Overkleeft , Jeroen D C Codée , Ivan Ahel , Dmitri V Filippov

PARP1 proximity proteomics reveals interaction partners at stressed replication forks.

Nucleic acids research

Avec: Thorsten Mosler , H Irem Baymaz , Justus F Gräf , Ivan Mikicic , Georges Blattner , Edward Bartlett , Matthias Ostermaier , Rossana Piccinno , Jiwen Yang , Andrea Voigt , Marco Gatti , Stefania Pellegrino , Matthias Altmeyer , Katja Luck , Ivan Ahel , Vassilis Roukos , Petra Beli

4-Thioribose Analogues of Adenosine Diphosphate Ribose (ADPr) Peptides.

Organic letters

Avec: Jerre M Madern , Jim Voorneveld , Johannes G M Rack , Hans A V Kistemaker , Ivan Ahel , Gijsbert A van der Marel , Jeroen D C Codée , Dmitri V Filippov

ADP-ribosylation from molecular mechanisms to therapeutic implications.

Cell

Avec: Marcin J Suskiewicz , Evgeniia Prokhorova , Johannes G M Rack , Ivan Ahel

Evolutionary and molecular basis of ADP-ribosylation reversal by zinc-dependent macrodomains.

The Journal of biological chemistry

Avec: Antonio Ariza , Qiang Liu , Nathan Cowieson , Ivan Ahel , Dmitri V Filippov , Johannes Gregor Matthias Rack

Reversible ADP-ribosylation of RNA.

Nucleic acids research

Avec: Deeksha Munnur , Edward Bartlett , Petra Mikolčević , Ilsa T Kirby , Johannes Gregor Matthias Rack , Andreja Mikoč , Michael S Cohen , Ivan Ahel

The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome.

Nature communications

Avec: Ivo A Hendriks , Sara C Buch-Larsen , Evgeniia Prokhorova , Jonas D Elsborg , Alexandra K L F S Rebak , Kang Zhu , Dragana Ahel , Claudia Lukas , Ivan Ahel , Michael L Nielsen

Detecting ADP-Ribosylation in RNA.

Methods in molecular biology (Clifton, N.J.)

Avec: Deeksha Munnur , Ivan Ahel

Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling.

Nature communications

Avec: Pietro Fontana , Sara C Buch-Larsen , Osamu Suyari , Rebecca Smith , Marcin J Suskiewicz , Kira Schützenhofer , Antonio Ariza , Johannes Gregor Matthias Rack , Michael L Nielsen , Ivan Ahel

The interplay of TARG1 and PARG protects against genomic instability.

Cell reports

Avec: Joséphine Groslambert , Evgeniia Prokhorova , Anne R Wondisford , Callum Tromans-Coia , Celeste Giansanti , Jennifer Jansen , Gyula Timinszky , Matthias Dobbelstein , Dragana Ahel , Roderick J O'Sullivan , Ivan Ahel

PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities.

Science advances

Avec: Nina Đukić , Øyvind Strømland , Jonas Damgaard Elsborg , Deeksha Munnur , Kang Zhu , Marion Schuller , Chatrin Chatrin , Pulak Kar , Lena Duma , Osamu Suyari , Johannes Gregor Matthias Rack , Domagoj Baretić , Dorian Richard Kenneth Crudgington , Joséphine Groslambert , Gerissa Fowler , Sven Wijngaarden , Evgeniia Prokhorova , Jan Rehwinkel , Herwig Schüler , Dmitri V Filippov , Sumana Sanyal , Dragana Ahel , Michael L Nielsen , Rebecca Smith , Ivan Ahel

The function and regulation of ADP-ribosylation in the DNA damage response.

Biochemical Society transactions

Avec: Lena Duma , Ivan Ahel

HPF1-dependent histone ADP-ribosylation triggers chromatin relaxation to promote the recruitment of repair factors at sites of DNA damage.

Nature structural & molecular biology

Avec: Rebecca Smith , Siham Zentout , Magdalena Rother , Nicolas Bigot , Catherine Chapuis , Alexandra Mihuț , Florian Franz Zobel , Ivan Ahel , Haico van Attikum , Gyula Timinszky , Sébastien Huet

A Simple Method to Study ADP-Ribosylation Reversal: From Function to Drug Discovery.

Methods in molecular biology (Clifton, N.J.)

Avec: Johannes Gregor Matthias Rack , Ivan Ahel

Discovery and Development Strategies for SARS-CoV-2 NSP3 Macrodomain Inhibitors.

Pathogens (Basel, Switzerland)

Avec: Marion Schuller , Tryfon Zarganes-Tzitzikas , James Bennett , Stephane De Cesco , Daren Fearon , Frank von Delft , Oleg Fedorov , Paul E Brennan , Ivan Ahel

PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation.

The EMBO journal

Avec: Pulak Kar , Chatrin Chatrin , Nina Đukić , Osamu Suyari , Marion Schuller , Kang Zhu , Evgeniia Prokhorova , Nicolas Bigot , Juraj Ahel , Jonas Damgaard Elsborg , Michael L Nielsen , Tim Clausen , Sébastien Huet , Mario Niepel , Sumana Sanyal , Dragana Ahel , Rebecca Smith , Ivan Ahel

Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist.

Journal of medicinal chemistry

Avec: Esra Balıkçı , Anne-Sophie M C Marques , Ludwig G Bauer , Raina Seupel , James Bennett , Brigitt Raux , Karly Buchan , Klemensas Simelis , Usha Singh , Catherine Rogers , Jennifer Ward , Carol Cheng , Tamas Szommer , Kira Schützenhofer , Jonathan M Elkins , David L Sloman , Ivan Ahel , Oleg Fedorov , Paul E Brennan , Kilian V M Huber

Deregulated DNA ADP-ribosylation impairs telomere replication.

Nature structural & molecular biology

Avec: Anne R Wondisford , Junyeop Lee , Robert Lu , Marion Schuller , Josephine Groslambert , Ragini Bhargava , Sandra Schamus-Haynes , Leyneir C Cespedes , Patricia L Opresko , Hilda A Pickett , Jaewon Min , Ivan Ahel , Roderick J O'Sullivan

HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.

Nature

Avec: Marcin J Suskiewicz , Florian Zobel , Tom E H Ogden , Pietro Fontana , Antonio Ariza , Ji-Chun Yang , Kang Zhu , Lily Bracken , William J Hawthorne , Dragana Ahel , David Neuhaus , Ivan Ahel

CARM1 regulates replication fork speed and stress response by stimulating PARP1.

Molecular cell

Avec: Marie-Michelle Genois , Jean-Philippe Gagné , Takaaki Yasuhara , Jessica Jackson , Sneha Saxena , Marie-France Langelier , Ivan Ahel , Mark T Bedford , John M Pascal , Alessandro Vindigni , Guy G Poirier , Lee Zou

Noncanonical mono(ADP-ribosyl)ation of zinc finger SZF proteins counteracts ubiquitination for protein homeostasis in plant immunity.

Molecular cell

Avec: Liang Kong , Baomin Feng , Yan Yan , Chao Zhang , Jun Hyeok Kim , Lahong Xu , Johannes Gregor Matthias Rack , Ying Wang , Jyan-Chyun Jang , Ivan Ahel , Libo Shan , Ping He

TARG1 protects against toxic DNA ADP-ribosylation.

Nucleic acids research

Avec: Callum Tromans-Coia , Andrea Sanchi , Giuliana K Moeller , Gyula Timinszky , Massimo Lopes , Ivan Ahel

Molecular basis for DarT ADP-ribosylation of a DNA base.

Nature

Avec: Marion Schuller , Rachel E Butler , Antonio Ariza , Callum Tromans-Coia , Gytis Jankevicius , Tim D W Claridge , Sharon L Kendall , Shan Goh , Graham R Stewart , Ivan Ahel

ADP-ribosyltransferases, an update on function and nomenclature.

The FEBS journal

Avec: Bernhard Lüscher , Ivan Ahel , Matthias Altmeyer , Alan Ashworth , Peter Bai , Paul Chang , Michael Cohen , Daniela Corda , Françoise Dantzer , Matthew D Daugherty , Ted M Dawson , Valina L Dawson , Sebastian Deindl , Anthony R Fehr , Karla L H Feijs , Dmitri V Filippov , Jean-Philippe Gagné , Giovanna Grimaldi , Sebastian Guettler , Nicolas C Hoch , Michael O Hottiger , Patricia Korn , W Lee Kraus , Andreas Ladurner , Lari Lehtiö , Anthony K L Leung , Christopher J Lord , Aswin Mangerich , Ivan Matic , Jason Matthews , George-Lucian Moldovan , Joel Moss , Gioacchino Natoli , Michael L Nielsen , Mario Niepel , Friedrich Nolte , John Pascal , Bryce M Paschal , Krzysztof Pawłowski , Guy G Poirier , Susan Smith , Gyula Timinszky , Zhao-Qi Wang , José Yélamos , Xiaochun Yu , Roko Zaja , Mathias Ziegler

Specificity of DNA ADP-Ribosylation Reversal by NADARs.

Toxins

Avec: Bara Cihlova , Yang Lu , Andreja Mikoč , Marion Schuller , Ivan Ahel

Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Stefan Gahbauer , Galen J Correy , Marion Schuller , Matteo P Ferla , Yagmur Umay Doruk , Moira Rachman , Taiasean Wu , Morgan Diolaiti , Siyi Wang , R Jeffrey Neitz , Daren Fearon , Dmytro S Radchenko , Yurii S Moroz , John J Irwin , Adam R Renslo , Jenny C Taylor , Jason E Gestwicki , Frank von Delft , Alan Ashworth , Ivan Ahel , Brian K Shoichet , James S Fraser

Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling.

Molecular cell

Avec: Edoardo José Longarini , Helen Dauben , Carolina Locatelli , Anne R Wondisford , Rebecca Smith , Charlotte Muench , Andreas Kolvenbach , Michelle Lee Lynskey , Alexis Pope , Juan José Bonfiglio , Eva Pinto Jurado , Roberta Fajka-Boja , Thomas Colby , Marion Schuller , Ivan Ahel , Gyula Timinszky , Roderick J O'Sullivan , Sébastien Huet , Ivan Matic

Updated protein domain annotation of the PARP protein family sheds new light on biological function.

Nucleic acids research

Avec: Marcin J Suskiewicz , Deeksha Munnur , Øyvind Strømland , Ji-Chun Yang , Laura E Easton , Chatrin Chatrin , Kang Zhu , Domagoj Baretić , Stéphane Goffinont , Marion Schuller , Wing-Fung Wu , Jonathan M Elkins , Dragana Ahel , Sumana Sanyal , David Neuhaus , Ivan Ahel

DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on nucleic acids.

Nucleic acids research

Avec: Kang Zhu , Marcin J Suskiewicz , Chatrin Chatrin , Øyvind Strømland , Bryan W Dorsey , Vincent Aucagne , Dragana Ahel , Ivan Ahel

Progress and outlook in studying the substrate specificities of PARPs and related enzymes.

The FEBS journal

Avec: Marcin J Suskiewicz , Luca Palazzo , Rebecca Hughes , Ivan Ahel

Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair.

Nature communications

Avec: Hana Hanzlikova , Evgeniia Prokhorova , Katerina Krejcikova , Zuzana Cihlarova , Ilona Kalasova , Jan Kubovciak , Jana Sachova , Richard Hailstone , Jan Brazina , Shereen Ghosh , Sebahattin Cirak , Joseph G Gleeson , Ivan Ahel , Keith W Caldecott

DNA ADP-Ribosylation Stalls Replication and Is Reversed by RecF-Mediated Homologous Recombination and Nucleotide Excision Repair.

Cell reports

Avec: Emeline Lawarée , Gytis Jankevicius , Charles Cooper , Ivan Ahel , Stephan Uphoff , Christoph M Tang

Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential.

Open biology

Avec: Johannes Gregor Matthias Rack , Valentina Zorzini , Zihan Zhu , Marion Schuller , Dragana Ahel , Ivan Ahel

Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking.

bioRxiv : the preprint server for biology

Avec: Marion Schuller , Galen J Correy , Stefan Gahbauer , Daren Fearon , Taiasean Wu , Roberto Efraín Díaz , Iris D Young , Luan Carvalho Martins , Dominique H Smith , Ursula Schulze-Gahmen , Tristan W Owens , Ishan Deshpande , Gregory E Merz , Aye C Thwin , Justin T Biel , Jessica K Peters , Michelle Moritz , Nadia Herrera , Huong T Kratochvil , Auteur inconnu , Anthony Aimon , James M Bennett , Jose Brandao Neto , Aina E Cohen , Alexandre Dias , Alice Douangamath , Louise Dunnett , Oleg Fedorov , Matteo P Ferla , Martin Fuchs , Tyler J Gorrie-Stone , James M Holton , Michael G Johnson , Tobias Krojer , George Meigs , Ailsa J Powell , Auteur inconnu , Victor L Rangel , Silvia Russi , Rachael E Skyner , Clyde A Smith , Alexei S Soares , Jennifer L Wierman , Kang Zhu , Natalia Jura , Alan Ashworth , John Irwin , Michael C Thompson , Jason E Gestwicki , Frank von Delft , Brian K Shoichet , James S Fraser , Ivan Ahel

Behavioural Characterisation of

Cells

Avec: Kerryanne Crawford , Peter L Oliver , Thomas Agnew , Benjamin H M Hunn , Ivan Ahel

Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease.

Molecular cell

Avec: Evgeniia Prokhorova , Thomas Agnew , Anne R Wondisford , Michael Tellier , Nicole Kaminski , Danique Beijer , James Holder , Josephine Groslambert , Marcin J Suskiewicz , Kang Zhu , Julia M Reber , Sarah C Krassnig , Luca Palazzo , Shona Murphy , Michael L Nielsen , Aswin Mangerich , Dragana Ahel , Jonathan Baets , Roderick J O'Sullivan , Ivan Ahel

Biallelic

Life science alliance

Avec: Danique Beijer , Thomas Agnew , Johannes Gregor Matthias Rack , Evgeniia Prokhorova , Tine Deconinck , Berten Ceulemans , Stojan Peric , Vedrana Milic Rasic , Peter De Jonghe , Ivan Ahel , Jonathan Baets

Beyond protein modification: the rise of non-canonical ADP-ribosylation.

The Biochemical journal

Avec: Marion Schuller , Ivan Ahel

Computational and structural biotechnology journal

Avec: Andrea Hloušek-Kasun , Petra Mikolčević , Johannes Gregor Matthias Rack , Callum Tromans-Coia , Marion Schuller , Gytis Jankevicius , Marija Matković , Branimir Bertoša , Ivan Ahel , Andreja Mikoč

Chemoenzymatic and Synthetic Approaches To Investigate Aspartate- and Glutamate-ADP-Ribosylation.

Journal of the American Chemical Society

Avec: Kyuto Tashiro , Sven Wijngaarden , Jugal Mohapatra , Johannes G M Rack , Ivan Ahel , Dmitri V Filippov , Glen Liszczak

Solid-Phase Synthesis and Biological Evaluation of Peptides ADP-Ribosylated at Histidine.

Angewandte Chemie (International ed. in English)

Avec: Hugo Minnee , Johannes G M Rack , Gijsbert A van der Marel , Herman S Overkleeft , Jeroen D C Codée , Ivan Ahel , Dmitri V Filippov

Four of a Kind: A Complete Collection of ADP-Ribosylated Histidine Isosteres Using Cu(I)- and Ru(II)-Catalyzed Click Chemistry.

The Journal of organic chemistry

Avec: Hugo Minnee , Hayley Chung , Johannes Gregor Matthias Rack , Gijsbert A van der Marel , Herman S Overkleeft , Jeroen D C Codée , Ivan Ahel , Dmitri V Filippov

Histone ADP-ribosylation promotes resistance to PARP inhibitors by facilitating PARP1 release from DNA lesions.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Siham Zentout , Victor Imburchia , Catherine Chapuis , Lena Duma , Kira Schützenhofer , Evgeniia Prokhorova , Ivan Ahel , Rebecca Smith , Sébastien Huet

Synthesis of Structural ADP-Ribose Analogues as Inhibitors for SARS-CoV-2 Macrodomain 1.

Organic letters

Avec: Koen J Rijpkema , Marion Schuller , Miriam S van der Veer , Sjoerd Rieken , Diego L R Chang , Pascal Balić , Alex Todorov , Hugo Minnee , Sven Wijngaarden , Isaac A Matos , Nicolas C Hoch , Jeroen D C Codée , Ivan Ahel , Dmitri V Filippov

Ubiquitylation of nucleic acids by DELTEX ubiquitin E3 ligase DTX3L.

EMBO reports

Avec: Kang Zhu , Chatrin Chatrin , Marcin J Suskiewicz , Vincent Aucagne , Benjamin Foster , Benedikt M Kessler , Ian Gibbs-Seymour , Dragana Ahel , Ivan Ahel

Reversal of tyrosine-linked ADP-ribosylation by ARH3 and PARG.

The Journal of biological chemistry

Avec: Johannes Gregor Matthias Rack , Jim Voorneveld , Edoardo José Longarini , Sven Wijngaarden , Kang Zhu , Alessandra Peters , Jia Jhing Sia , Evgeniia Prokhorova , Dragana Ahel , Ivan Matić , Dmitri V Filippov , Ivan Ahel

Réseau de co-auteurs

Marion Schuller 18 collaborations

Johannes Gregor Matthias Rack 17 collaborations

Dragana Ahel 15 collaborations

Dmitri V Filippov 14 collaborations

Kang Zhu 13 collaborations

Evgeniia Prokhorova 12 collaborations

Marcin J Suskiewicz 12 collaborations

Rebecca Smith 7 collaborations

Michael L Nielsen 7 collaborations

Gijsbert A van der Marel 7 collaborations

Johannes G M Rack 7 collaborations

Daren Fearon 6 collaborations

Frank von Delft 6 collaborations

Antonio Ariza 6 collaborations

Jeroen D C Codée 6 collaborations

Andreja Mikoč 6 collaborations

Alan Ashworth 5 collaborations

Kira Schützenhofer 5 collaborations

Sébastien Huet 5 collaborations

Jim Voorneveld 5 collaborations

Hugo Minnee 5 collaborations

Herman S Overkleeft 5 collaborations

Luca Palazzo 5 collaborations

Deeksha Munnur 5 collaborations

Gyula Timinszky 5 collaborations

Chatrin Chatrin 5 collaborations

Galen J Correy 4 collaborations

Stefan Gahbauer 4 collaborations

Taiasean Wu 4 collaborations

Oleg Fedorov 4 collaborations

Matteo P Ferla 4 collaborations

Jason E Gestwicki 4 collaborations

Brian K Shoichet 4 collaborations

James S Fraser 4 collaborations

Joséphine Groslambert 4 collaborations

Thomas Agnew 4 collaborations

Petra Mikolčević 4 collaborations

Anne R Wondisford 4 collaborations

Callum Tromans-Coia 4 collaborations

Roderick J O'Sullivan 4 collaborations

Sven Wijngaarden 4 collaborations

None None 3 collaborations

Alice Douangamath 3 collaborations

John J Irwin 3 collaborations

Siham Zentout 3 collaborations

Valentina Zorzini 3 collaborations

Qiang Liu 3 collaborations

Aswin Mangerich 3 collaborations

Andrea Hloušek-Kasun 3 collaborations

Vincent Aucagne 3 collaborations

Osamu Suyari 3 collaborations

Øyvind Strømland 3 collaborations

Lena Duma 3 collaborations

Sumana Sanyal 3 collaborations

Gytis Jankevicius 3 collaborations

Roberto Efraín Díaz 2 collaborations

Iris D Young 2 collaborations

Luan Carvalho Martins 2 collaborations

Dominique H Smith 2 collaborations

Ursula Schulze-Gahmen 2 collaborations

Tristan W Owens 2 collaborations

Ishan Deshpande 2 collaborations

Gregory E Merz 2 collaborations

Aye C Thwin 2 collaborations

Justin T Biel 2 collaborations

Jessica K Peters 2 collaborations

Michelle Moritz 2 collaborations

Nadia Herrera 2 collaborations

Huong T Kratochvil 2 collaborations

Anthony Aimon 2 collaborations

James M Bennett 2 collaborations

Jose Brandao Neto 2 collaborations

Aina E Cohen 2 collaborations

Alexandre Dias 2 collaborations

Louise Dunnett 2 collaborations

Tyler J Gorrie-Stone 2 collaborations

James M Holton 2 collaborations

Michael G Johnson 2 collaborations

Tobias Krojer 2 collaborations

George Meigs 2 collaborations

Ailsa J Powell 2 collaborations

Victor L Rangel 2 collaborations

Silvia Russi 2 collaborations

Rachael E Skyner 2 collaborations

Clyde A Smith 2 collaborations

Alexei S Soares 2 collaborations

Jennifer L Wierman 2 collaborations

Natalia Jura 2 collaborations

Michael C Thompson 2 collaborations

Florian Zobel 2 collaborations

Ian Gibbs-Seymour 2 collaborations

Alessandra Peters 2 collaborations

Julia M Reber 2 collaborations

Sarah C Krassnig 2 collaborations

Yagmur Umay Doruk 2 collaborations

Moira Rachman 2 collaborations

Morgan Diolaiti 2 collaborations

Siyi Wang 2 collaborations

R Jeffrey Neitz 2 collaborations

Adam R Renslo 2 collaborations

Jenny C Taylor 2 collaborations

Christopher J Lord 2 collaborations

Sebastian Deindl 2 collaborations

Edward Bartlett 2 collaborations

Matthias Altmeyer 2 collaborations

Sara C Buch-Larsen 2 collaborations

Pietro Fontana 2 collaborations

Nina Đukić 2 collaborations

Jonas Damgaard Elsborg 2 collaborations

Pulak Kar 2 collaborations

Domagoj Baretić 2 collaborations

Nicolas Bigot 2 collaborations

Catherine Chapuis 2 collaborations

James Bennett 2 collaborations

Paul E Brennan 2 collaborations

Mario Niepel 2 collaborations

Jonathan M Elkins 2 collaborations

Josephine Groslambert 2 collaborations

Ji-Chun Yang 2 collaborations

David Neuhaus 2 collaborations

Jean-Philippe Gagné 2 collaborations

Guy G Poirier 2 collaborations

Nicolas C Hoch 2 collaborations

Ivan Matic 2 collaborations

Edoardo José Longarini 2 collaborations

Danique Beijer 2 collaborations

Jonathan Baets 2 collaborations

Martin R Fuchs 1 collaboration

Peter O'Brien 1 collaboration

Dávid Bajusz 1 collaboration

Warren S Wade 1 collaboration

Grzegorz Satała 1 collaboration

Andrzej J Bojarski 1 collaboration

Janez Ilaš 1 collaboration

Jessica Ebner 1 collaboration

Florian Grebien 1 collaboration

Henrietta Papp 1 collaboration

Ferenc Jakab 1 collaboration

Amanda Wakefield 1 collaboration

Sándor Vajda 1 collaboration

János Gerencsér 1 collaboration

Péter Pallai 1 collaboration

György M Keserű 1 collaboration

John Brognard 1 collaboration

Kourosh Honarmand Ebrahimi 1 collaboration

James S O McCullagh 1 collaboration

Dmytro Radchenko 1 collaboration

Yurii Moroz 1 collaboration

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