ADP-ribosylation from molecular mechanisms to therapeutic implications.

Humans ADP-Ribosylation Proteins / metabolism DNA / metabolism RNA / metabolism Animals Signal Transduction Protein Processing, Post-Translational ADP Ribose Transferases / metabolism Poly (ADP-Ribose) Polymerase-1 / metabolism

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
12 10 2023
Historique:
received: 28 04 2023
revised: 23 08 2023
accepted: 23 08 2023
medline: 1 11 2023
pubmed: 14 10 2023
entrez: 13 10 2023
Statut: ppublish

Résumé

ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent emergence of new technologies to study ADP-ribosylation has reshaped our understanding of the molecular mechanisms that govern the establishment, removal, and recognition of this modification, as well as its impact on cellular and organismal function. These advances have also revealed the intricate involvement of ADP-ribosylation in human physiology and pathology and the enormous potential that their manipulation holds for therapy. In this review, we present the state-of-the-art findings covering the work in structural biology, biochemistry, cell biology, and clinical aspects of ADP-ribosylation.

Identifiants

DOI: 10.1016/j.cell.2023.08.030 PMID: 37832523
pubmed: 37832523
pii: S0092-8674(23)00962-5
doi: 10.1016/j.cell.2023.08.030
pii:
doi:

Substances chimiques

Proteins 0
DNA 9007-49-2
RNA 63231-63-0
ADP Ribose Transferases EC 2.4.2.-
Poly (ADP-Ribose) Polymerase-1 EC 2.4.2.30

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4475-4495

Subventions

Organisme : Medical Research Council
ID : MR/N006364/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V033417/1
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 210634
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 223107
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/R007195/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/X007472/1
Pays : United Kingdom

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests E.P. is an employee of Vertex Pharmaceuticals and may own stock or stock options in that company.

Auteurs

Marcin J Suskiewicz (MJ)

Centre de Biophysique Moléculaire, CNRS, Orléans, France.

Evgeniia Prokhorova (E)

Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.

Johannes G M Rack (JGM)

Sir William Dunn School of Pathology, University of Oxford, Oxford, UK; MRC Centre of Medical Mycology, University of Exeter, Exeter, UK.

Ivan Ahel (I)

Sir William Dunn School of Pathology, University of Oxford, Oxford, UK. Electronic address: ivan.ahel@path.ox.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › ADP-ribosylation from molecular mechanisms to...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › ADP-Ribosylation › ADP-ribosylation from molecular mechanisms to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › ADP-ribosylation from molecular mechanisms to...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADP-ribosylation from molecular mechanisms to...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ADP-ribosylation from molecular mechanisms to...
questionsmedicales.fr › Eucaryotes › Animaux › ADP-ribosylation from molecular mechanisms to...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › ADP-ribosylation from molecular mechanisms to...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › ADP-ribosylation from molecular mechanisms to...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Pentosyltransferases › ADP ribose transferases › ADP-ribosylation from molecular mechanisms to...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Pentosyltransferases › ADP ribose transferases › Poly(ADP-ribose) polymerases › Poly (ADP-Ribose) polymerase-1 › ADP-ribosylation from molecular mechanisms to...