Vassilis Roukos

Affiliations

Institute of Molecular Biology, 55128 Mainz, Germany.

ORCID: 0000-0002-5065-3937

Publications (13)

Targeting PARP-1 and DNA Damage Response Defects in Colorectal Cancer Chemotherapy with Established and Novel PARP Inhibitors.

Cancers

Avec: Philipp Demuth , Lea Thibol , Anna Lemsch , Felix Potlitz , Lukas Schulig , Christoph Grathwol , Georg Manolikakes , Dennis Schade , Vassilis Roukos , Andreas Link , Jörg Fahrer

RNA polymerase II is required for spatial chromatin reorganization following exit from mitosis.

Science advances

Avec: Shu Zhang , Nadine Übelmesser , Natasa Josipovic , Giada Forte , Johan A Slotman , Michael Chiang , Henrike Johanna Gothe , Eduardo Gade Gusmao , Christian Becker , Janine Altmüller , Adriaan B Houtsmuller , Vassilis Roukos , Kerstin S Wendt , Davide Marenduzzo , Argyris Papantonis

High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue.

Nature communications

Avec: Ning Zhang , Luuk Harbers , Michele Simonetti , Constantin Diekmann , Quentin Verron , Enrico Berrino , Sara E Bellomo , Gabriel M C Longo , Michael Ratz , Niklas Schultz , Firas Tarish , Peng Su , Bo Han , Wanzhong Wang , Sofia Onorato , Dora Grassini , Roberto Ballarino , Silvia Giordano , Qifeng Yang , Anna Sapino , Jonas Frisén , Kanar Alkass , Henrik Druid , Vassilis Roukos , Thomas Helleday , Caterina Marchiò , Magda Bienko , Nicola Crosetto

Linking CRISPR-Cas9 double-strand break profiles to gene editing precision with BreakTag.

Nature biotechnology

Avec: Gabriel M C Longo , Sergi Sayols , Andriana G Kotini , Sabine Heinen , Martin M Möckel , Petra Beli , Vassilis Roukos

R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instability.

Nature communications

Avec: Thorsten Mosler , Francesca Conte , Gabriel M C Longo , Ivan Mikicic , Nastasja Kreim , Martin M Möckel , Giuseppe Petrosino , Johanna Flach , Joan Barau , Brian Luke , Vassilis Roukos , Petra Beli

Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations.

Molecular cell

Avec: Henrike Johanna Gothe , Britta Annika Maria Bouwman , Eduardo Gade Gusmao , Rossana Piccinno , Giuseppe Petrosino , Sergi Sayols , Oliver Drechsel , Vera Minneker , Natasa Josipovic , Athanasia Mizi , Christian Friberg Nielsen , Eva-Maria Wagner , Shunichi Takeda , Hiroyuki Sasanuma , Damien Francis Hudson , Thomas Kindler , Laura Baranello , Argyris Papantonis , Nicola Crosetto , Vassilis Roukos

53BP1-mediated recruitment of RASSF1A to ribosomal DNA breaks promotes local ATM signaling.

EMBO reports

Avec: Stavroula Tsaridou , Georgia Velimezi , Frances Willenbrock , Maria Chatzifrangkeskou , Waheba Elsayed , Andreas Panagopoulos , Dimitris Karamitros , Vassilis Gorgoulis , Zoi Lygerou , Vassilis Roukos , Eric O'Neill , Dafni Eleftheria Pefani

53BP1-DNA repair enters a new liquid phase.

The EMBO journal

Avec: Rossana Piccinno , Vera Minneker , Vassilis Roukos

Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration.

Nature communications

Avec: Bojana Lucic , Heng-Chang Chen , Maja Kuzman , Eduard Zorita , Julia Wegner , Vera Minneker , Wei Wang , Raffaele Fronza , Stefanie Laufs , Manfred Schmidt , Ralph Stadhouders , Vassilis Roukos , Kristian Vlahovicek , Guillaume J Filion , Marina Lusic

Genome-wide detection of DNA double-strand breaks by in-suspension BLISS.

Nature protocols

Avec: Britta A M Bouwman , Federico Agostini , Silvano Garnerone , Giuseppe Petrosino , Henrike J Gothe , Sergi Sayols , Andreas E Moor , Shalev Itzkovitz , Magda Bienko , Vassilis Roukos , Nicola Crosetto

RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1.

The Journal of clinical investigation

Avec: Bassam Abu-Libdeh , Satpal S Jhujh , Srijita Dhar , Joshua A Sommers , Arindam Datta , Gabriel Mc Longo , Laura J Grange , John J Reynolds , Sophie L Cooke , Gavin S McNee , Robert Hollingworth , Beth L Woodward , Anil N Ganesh , Stephen J Smerdon , Claudia M Nicolae , Karina Durlacher-Betzer , Vered Molho-Pessach , Abdulsalam Abu-Libdeh , Vardiella Meiner , George-Lucian Moldovan , Vassilis Roukos , Tamar Harel , Robert M Brosh , Grant S Stewart

Cdt1 overexpression drives colorectal carcinogenesis through origin overlicensing and DNA damage.

The Journal of pathology

Avec: Michalis Petropoulos , Spyridon Champeris Tsaniras , Sofia Nikou , Styliani Maxouri , Vasilis S Dionellis , Argyro Kalogeropoulou , Angeliki Karamichali , Konstantinos Ioannidis , Iosif-Rodolfos Danalatos , Mandy Obst , Ronald Naumann , George J Delinasios , Vassilis G Gorgoulis , Vassilis Roukos , Konstantinos Anastassiadis , Thanos D Halazonetis , Vasiliki Bravou , Zoi Lygerou , Stavros Taraviras

PARP1 proximity proteomics reveals interaction partners at stressed replication forks.

Nucleic acids research

Avec: Thorsten Mosler , H Irem Baymaz , Justus F Gräf , Ivan Mikicic , Georges Blattner , Edward Bartlett , Matthias Ostermaier , Rossana Piccinno , Jiwen Yang , Andrea Voigt , Marco Gatti , Stefania Pellegrino , Matthias Altmeyer , Katja Luck , Ivan Ahel , Vassilis Roukos , Petra Beli

Réseau de co-auteurs

Gabriel M C Longo 3 collaborations

Nicola Crosetto 3 collaborations

Sergi Sayols 3 collaborations

Petra Beli 3 collaborations

Giuseppe Petrosino 3 collaborations

Rossana Piccinno 3 collaborations

Vera Minneker 3 collaborations

Natasa Josipovic 2 collaborations

Henrike Johanna Gothe 2 collaborations

Eduardo Gade Gusmao 2 collaborations

Argyris Papantonis 2 collaborations

Magda Bienko 2 collaborations

Martin M Möckel 2 collaborations

Thorsten Mosler 2 collaborations

Ivan Mikicic 2 collaborations

Zoi Lygerou 2 collaborations

Philipp Demuth 1 collaboration

Lea Thibol 1 collaboration

Anna Lemsch 1 collaboration

Felix Potlitz 1 collaboration

Lukas Schulig 1 collaboration

Christoph Grathwol 1 collaboration

Georg Manolikakes 1 collaboration

Dennis Schade 1 collaboration

Andreas Link 1 collaboration

Jörg Fahrer 1 collaboration

Shu Zhang 1 collaboration

Nadine Übelmesser 1 collaboration

Giada Forte 1 collaboration

Johan A Slotman 1 collaboration

Michael Chiang 1 collaboration

Christian Becker 1 collaboration

Janine Altmüller 1 collaboration

Adriaan B Houtsmuller 1 collaboration

Kerstin S Wendt 1 collaboration

Davide Marenduzzo 1 collaboration

Ning Zhang 1 collaboration

Luuk Harbers 1 collaboration

Michele Simonetti 1 collaboration

Constantin Diekmann 1 collaboration

Quentin Verron 1 collaboration

Enrico Berrino 1 collaboration

Sara E Bellomo 1 collaboration

Michael Ratz 1 collaboration

Niklas Schultz 1 collaboration

Firas Tarish 1 collaboration

Peng Su 1 collaboration

Bo Han 1 collaboration

Wanzhong Wang 1 collaboration

Sofia Onorato 1 collaboration

Dora Grassini 1 collaboration

Roberto Ballarino 1 collaboration

Silvia Giordano 1 collaboration

Qifeng Yang 1 collaboration

Anna Sapino 1 collaboration

Jonas Frisén 1 collaboration

Kanar Alkass 1 collaboration

Henrik Druid 1 collaboration

Thomas Helleday 1 collaboration

Caterina Marchiò 1 collaboration

Andriana G Kotini 1 collaboration

Sabine Heinen 1 collaboration

Francesca Conte 1 collaboration

Nastasja Kreim 1 collaboration

Johanna Flach 1 collaboration

Joan Barau 1 collaboration

Brian Luke 1 collaboration

Britta Annika Maria Bouwman 1 collaboration

Oliver Drechsel 1 collaboration

Athanasia Mizi 1 collaboration

Christian Friberg Nielsen 1 collaboration

Eva-Maria Wagner 1 collaboration

Shunichi Takeda 1 collaboration

Hiroyuki Sasanuma 1 collaboration

Damien Francis Hudson 1 collaboration

Thomas Kindler 1 collaboration

Laura Baranello 1 collaboration

Stavroula Tsaridou 1 collaboration

Georgia Velimezi 1 collaboration

Frances Willenbrock 1 collaboration

Maria Chatzifrangkeskou 1 collaboration

Waheba Elsayed 1 collaboration

Andreas Panagopoulos 1 collaboration

Dimitris Karamitros 1 collaboration

Vassilis Gorgoulis 1 collaboration

Eric O'Neill 1 collaboration

Dafni Eleftheria Pefani 1 collaboration

Bojana Lucic 1 collaboration

Heng-Chang Chen 1 collaboration

Maja Kuzman 1 collaboration

Eduard Zorita 1 collaboration

Julia Wegner 1 collaboration

Wei Wang 1 collaboration

Raffaele Fronza 1 collaboration

Stefanie Laufs 1 collaboration

Manfred Schmidt 1 collaboration

Ralph Stadhouders 1 collaboration

Kristian Vlahovicek 1 collaboration

Guillaume J Filion 1 collaboration

Marina Lusic 1 collaboration

Britta A M Bouwman 1 collaboration

Federico Agostini 1 collaboration

Silvano Garnerone 1 collaboration

Henrike J Gothe 1 collaboration

Andreas E Moor 1 collaboration

Shalev Itzkovitz 1 collaboration

Bassam Abu-Libdeh 1 collaboration

Satpal S Jhujh 1 collaboration

Srijita Dhar 1 collaboration

Joshua A Sommers 1 collaboration

Arindam Datta 1 collaboration

Gabriel Mc Longo 1 collaboration

Laura J Grange 1 collaboration

John J Reynolds 1 collaboration

Sophie L Cooke 1 collaboration

Gavin S McNee 1 collaboration

Robert Hollingworth 1 collaboration

Beth L Woodward 1 collaboration

Anil N Ganesh 1 collaboration

Stephen J Smerdon 1 collaboration

Claudia M Nicolae 1 collaboration

Karina Durlacher-Betzer 1 collaboration

Vered Molho-Pessach 1 collaboration

Abdulsalam Abu-Libdeh 1 collaboration

Vardiella Meiner 1 collaboration

George-Lucian Moldovan 1 collaboration

Tamar Harel 1 collaboration

Robert M Brosh 1 collaboration

Grant S Stewart 1 collaboration

Michalis Petropoulos 1 collaboration

Spyridon Champeris Tsaniras 1 collaboration

Sofia Nikou 1 collaboration

Styliani Maxouri 1 collaboration

Vasilis S Dionellis 1 collaboration

Argyro Kalogeropoulou 1 collaboration

Angeliki Karamichali 1 collaboration

Konstantinos Ioannidis 1 collaboration

Iosif-Rodolfos Danalatos 1 collaboration

Mandy Obst 1 collaboration

Ronald Naumann 1 collaboration

George J Delinasios 1 collaboration

Vassilis G Gorgoulis 1 collaboration

Konstantinos Anastassiadis 1 collaboration

Thanos D Halazonetis 1 collaboration

Vasiliki Bravou 1 collaboration

Stavros Taraviras 1 collaboration

H Irem Baymaz 1 collaboration

Justus F Gräf 1 collaboration

Georges Blattner 1 collaboration

Edward Bartlett 1 collaboration

Matthias Ostermaier 1 collaboration

Jiwen Yang 1 collaboration

Andrea Voigt 1 collaboration

Marco Gatti 1 collaboration

Stefania Pellegrino 1 collaboration

Matthias Altmeyer 1 collaboration

Katja Luck 1 collaboration

Ivan Ahel 1 collaboration