Shalev Itzkovitz

Affiliations

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. shalev.itzkovitz@weizmann.ac.il.

Publications (31)

Spatial sorting enables comprehensive characterization of liver zonation.

Nature metabolism

Avec: Shani Ben-Moshe , Yonatan Shapira , Andreas E Moor , Rita Manco , Tamar Veg , Keren Bahar Halpern , Shalev Itzkovitz

Spatial heterogeneity in the mammalian liver.

Nature reviews. Gastroenterology & hepatology

Avec: Shani Ben-Moshe , Shalev Itzkovitz

Single-cell atlas of the human neonatal small intestine affected by necrotizing enterocolitis.

PLoS biology

Avec: Adi Egozi , Oluwabunmi Olaloye , Lael Werner , Tatiana Silva , Blake McCourt , Richard W Pierce , Xiaojing An , Fujing Wang , Kong Chen , Jordan S Pober , Dror Shouval , Shalev Itzkovitz , Liza Konnikova

Diet Diurnally Regulates Small Intestinal Microbiome-Epithelial-Immune Homeostasis and Enteritis.

Cell

Avec: Timur Tuganbaev , Uria Mor , Stavros Bashiardes , Timur Liwinski , Samuel Philip Nobs , Avner Leshem , Mally Dori-Bachash , Christoph A Thaiss , Elisha Y Pinker , Karina Ratiner , Lorenz Adlung , Sara Federici , Christian Kleimeyer , Claudia Moresi , Takahiro Yamada , Yotam Cohen , Xiao Zhang , Hassan Massalha , Efi Massasa , Yael Kuperman , Pandelakis A Koni , Alon Harmelin , Nan Gao , Shalev Itzkovitz , Kenya Honda , Hagit Shapiro , Eran Elinav

Host transcriptome signatures in human faecal-washes predict histological remission in patients with IBD.

Gut

Avec: Bella Ungar , Miri Yavzori , Ella Fudim , Orit Picard , Uri Kopylov , Rami Eliakim , Dror Shouval , Yishai Levin , Alon Savidor , Shani Ben-Moshe , Rita Manco , Stav Dan , Adi Egozi , Keren Bahar Halpern , Chen Mayer , Iris Barshack , Shomron Ben-Horin , Shalev Itzkovitz

Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains.

bioRxiv : the preprint server for biology

Avec: Rachel K Zwick , Petr Kasparek , Brisa Palikuqi , Sara Viragova , Laura Weichselbaum , Christopher S McGinnis , Kara L McKinley , Asoka Rathnayake , Dedeepya Vaka , Vinh Nguyen , Coralie Trentesaux , Efren Reyes , Alexander R Gupta , Zev J Gartner , Richard M Locksley , James M Gardner , Shalev Itzkovitz , Dario Boffelli , Ophir D Klein

Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains.

Nature cell biology

Single-Cell Analysis of Diverse Pathogen Responses Defines a Molecular Roadmap for Generating Antigen-Specific Immunity.

Cell systems

Avec: Ronnie Blecher-Gonen , Pierre Bost , Kerry L Hilligan , Eyal David , Tomer Meir Salame , Elsa Roussel , Lisa M Connor , Johannes U Mayer , Keren Bahar Halpern , Beáta Tóth , Shalev Itzkovitz , Benno Schwikowski , Franca Ronchese , Ido Amit

Single cell biology-a Keystone Symposia report.

Annals of the New York Academy of Sciences

Avec: Jennifer Cable , Michael B Elowitz , Ana I Domingos , Naomi Habib , Shalev Itzkovitz , Homaira Hamidzada , Michael S Balzer , Itai Yanai , Prisca Liberali , Jessica Whited , Aaron Streets , Long Cai , Andrew B Stergachis , Clarice Kit Yee Hong , Leeat Keren , Martin Guilliams , Uri Alon , Alex K Shalek , Regan Hamel , Sarah J Pfau , Arjun Raj , Stephen R Quake , Nancy R Zhang , Jean Fan , Cole Trapnell , Bo Wang , Noah F Greenwald , Roser Vento-Tormo , Silvia D M Santos , Sabrina L Spencer , Hernan G Garcia , Geethika Arekatla , Federico Gaiti , Rinat Arbel-Goren , Steffen Rulands , Jan Philipp Junker , Allon M Klein , Samantha A Morris , John I Murray , Kate E Galloway , Michael Ratz , Merrit Romeike

Protocol for Single-Molecule Fluorescence

STAR protocols

Avec: Lydia Farack , Shalev Itzkovitz

Clump sequencing exposes the spatial expression programs of intestinal secretory cells.

Nature communications

Avec: Rita Manco , Inna Averbukh , Ziv Porat , Keren Bahar Halpern , Ido Amit , Shalev Itzkovitz

Spatial discordances between mRNAs and proteins in the intestinal epithelium.

Nature metabolism

Avec: Yotam Harnik , Lisa Buchauer , Shani Ben-Moshe , Inna Averbukh , Yishai Levin , Alon Savidor , Raya Eilam , Andreas E Moor , Shalev Itzkovitz

Physically interacting beta-delta pairs in the regenerating pancreas revealed by single-cell sequencing.

Molecular metabolism

Avec: Eran Yanowski , Nancy S Yacovzada , Eyal David , Amir Giladi , Diego Jaitin , Lydia Farack , Adi Egozi , Danny Ben-Zvi , Shalev Itzkovitz , Ido Amit , Eran Hornstein

A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie-Wnt signaling axis in the liver.

Developmental cell

Avec: Donato Inverso , Jingjing Shi , Ki Hong Lee , Moritz Jakab , Shani Ben-Moshe , Shubhada R Kulkarni , Martin Schneider , Guanxiong Wang , Marziyeh Komeili , Paula Argos Vélez , Maria Riedel , Carleen Spegg , Thomas Ruppert , Christine Schaeffer-Reiss , Dominic Helm , Indrabahadur Singh , Michael Boutros , Sudhakar Chintharlapalli , Mathias Heikenwalder , Shalev Itzkovitz , Hellmut G Augustin

Space-time logic of liver gene expression at sub-lobular scale.

Nature metabolism

Avec: Colas Droin , Jakob El Kholtei , Keren Bahar Halpern , Clémence Hurni , Milena Rozenberg , Sapir Muvkadi , Shalev Itzkovitz , Felix Naef

Bi-fated tendon-to-bone attachment cells are regulated by shared enhancers and KLF transcription factors.

eLife

Avec: Shiri Kult , Tsviya Olender , Marco Osterwalder , Svetalana Markman , Dena Leshkowitz , Sharon Krief , Ronnie Blecher-Gonen , Shani Ben-Moshe , Lydia Farack , Hadas Keren-Shaul , Tomer-Meir Salame , Terence D Capellini , Shalev Itzkovitz , Ido Amit , Axel Visel , Elazar Zelzer

The spatiotemporal program of zonal liver regeneration following acute injury.

Cell stem cell

Avec: Shani Ben-Moshe , Tamar Veg , Rita Manco , Stav Dan , Delfina Papinutti , Aviezer Lifshitz , Aleksandra A Kolodziejczyk , Keren Bahar Halpern , Eran Elinav , Shalev Itzkovitz

A spatiotemporally resolved single-cell atlas of the Plasmodium liver stage.

Nature

Avec: Amichay Afriat , Vanessa Zuzarte-Luís , Keren Bahar Halpern , Lisa Buchauer , Sofia Marques , Ângelo Ferreira Chora , Aparajita Lahree , Ido Amit , Maria M Mota , Shalev Itzkovitz

Distal Fecal Wash Host Transcriptomics Identifies Inflammation Throughout the Colon and Terminal Ileum.

Cellular and molecular gastroenterology and hepatology

Avec: Stav Dan , Bella Ungar , Shani Ben-Moshe , Keren Bahar Halpern , Miri Yavzori , Ella Fudim , Orit Picard , Chaya Mushka Abitbol , Sivan Harnik , Iris Barshack , Uri Kopylov , Shomron Ben-Horin , Shalev Itzkovitz

Transcriptional Heterogeneity of Beta Cells in the Intact Pancreas.

Developmental cell

Avec: Lydia Farack , Matan Golan , Adi Egozi , Nili Dezorella , Keren Bahar Halpern , Shani Ben-Moshe , Immacolata Garzilli , Beáta Tóth , Lior Roitman , Valery Krizhanovsky , Shalev Itzkovitz

Lgr5+ telocytes are a signaling source at the intestinal villus tip.

Nature communications

Avec: Keren Bahar Halpern , Hassan Massalha , Rachel K Zwick , Andreas E Moor , David Castillo-Azofeifa , Milena Rozenberg , Lydia Farack , Adi Egozi , Dan R Miller , Inna Averbukh , Yotam Harnik , Noa Weinberg-Corem , Frederic J de Sauvage , Ido Amit , Ophir D Klein , Michal Shoshkes-Carmel , Shalev Itzkovitz

Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling.

Nature communications

Avec: Eman Khatib-Massalha , Suditi Bhattacharya , Hassan Massalha , Adi Biram , Karin Golan , Orit Kollet , Anju Kumari , Francesca Avemaria , Ekaterina Petrovich-Kopitman , Shiri Gur-Cohen , Tomer Itkin , Isabell Brandenburger , Asaf Spiegel , Ziv Shulman , Zachary Gerhart-Hines , Shalev Itzkovitz , Matthias Gunzer , Stefan Offermanns , Ronen Alon , Amiram Ariel , Tsvee Lapidot

Zonation of Pancreatic Acinar Cells in Diabetic Mice.

Cell reports

Avec: Adi Egozi , Keren Bahar Halpern , Lydia Farack , Hagar Rotem , Shalev Itzkovitz

Spatial gene expression maps of the intestinal lymphoid follicle and associated epithelium identify zonated expression programs.

PLoS biology

Avec: Noam Cohen , Hassan Massalha , Shani Ben-Moshe , Adi Egozi , Milena Rozenberg , Keren Bahar Halpern , Shalev Itzkovitz

Insulin is expressed by enteroendocrine cells during human fetal development.

Nature medicine

Avec: Adi Egozi , Dhana Llivichuzhca-Loja , Blake T McCourt , Keren Bahar Halpern , Lydia Farack , Xiaojing An , Fujing Wang , Kong Chen , Liza Konnikova , Shalev Itzkovitz

Genome-wide detection of DNA double-strand breaks by in-suspension BLISS.

Nature protocols

Avec: Britta A M Bouwman , Federico Agostini , Silvano Garnerone , Giuseppe Petrosino , Henrike J Gothe , Sergi Sayols , Andreas E Moor , Shalev Itzkovitz , Magda Bienko , Vassilis Roukos , Nicola Crosetto

A single cell atlas of the human liver tumor microenvironment.

Molecular systems biology

Avec: Hassan Massalha , Keren Bahar Halpern , Samir Abu-Gazala , Tamar Jana , Efi E Massasa , Andreas E Moor , Lisa Buchauer , Milena Rozenberg , Eli Pikarsky , Ido Amit , Gideon Zamir , Shalev Itzkovitz

Interleukin-6 produced by enteric neurons regulates the number and phenotype of microbe-responsive regulatory T cells in the gut.

Immunity

Avec: Yiqing Yan , Deepshika Ramanan , Milena Rozenberg , Kelly McGovern , Daniella Rastelli , Brinda Vijaykumar , Omar Yaghi , Tiphaine Voisin , Munir Mosaheb , Isaac Chiu , Shalev Itzkovitz , Meenakshi Rao , Diane Mathis , Christophe Benoist

Single-cell biology: what does the future hold?

Molecular systems biology

Avec: Maria Polychronidou , Jingyi Hou , M Madan Babu , Prisca Liberali , Ido Amit , Bart Deplancke , Galit Lahav , Shalev Itzkovitz , Matthias Mann , Julio Saez-Rodriguez , Fabian Theis , Roland Eils

The cellular states and fates of shed intestinal cells.

Nature metabolism

Avec: Keren Bahar Halpern , Yael Korem Kohanim , Adi Biram , Yotam Harnik , Adi Egozi , Oran Yakubovsky , Ziv Shulman , Shalev Itzkovitz

A spatial expression atlas of the adult human proximal small intestine.

Nature

Avec: Yotam Harnik , Oran Yakubovsky , Rouven Hoefflin , Roy Novoselsky , Keren Bahar Halpern , Tal Barkai , Yael Korem Kohanim , Adi Egozi , Ofra Golani , Yoseph Addadi , Merav Kedmi , Tal Keidar Haran , Yishai Levin , Alon Savidor , Hadas Keren-Shaul , Chen Mayer , Niv Pencovich , Ron Pery , Dror S Shouval , Itay Tirosh , Ido Nachmany , Shalev Itzkovitz

Réseau de co-auteurs

Keren Bahar Halpern 16 collaborations

Shani Ben-Moshe 10 collaborations

Adi Egozi 10 collaborations

Ido Amit 8 collaborations

Lydia Farack 7 collaborations

Andreas E Moor 5 collaborations

Hassan Massalha 5 collaborations

Milena Rozenberg 5 collaborations

Rita Manco 4 collaborations

Yotam Harnik 4 collaborations

Yishai Levin 3 collaborations

Alon Savidor 3 collaborations

Stav Dan 3 collaborations

Rachel K Zwick 3 collaborations

Ophir D Klein 3 collaborations

Inna Averbukh 3 collaborations

Lisa Buchauer 3 collaborations

Tamar Veg 2 collaborations

Xiaojing An 2 collaborations

Fujing Wang 2 collaborations

Kong Chen 2 collaborations

Dror Shouval 2 collaborations

Liza Konnikova 2 collaborations

Eran Elinav 2 collaborations

Bella Ungar 2 collaborations

Miri Yavzori 2 collaborations

Ella Fudim 2 collaborations

Orit Picard 2 collaborations

Uri Kopylov 2 collaborations

Chen Mayer 2 collaborations

Iris Barshack 2 collaborations

Shomron Ben-Horin 2 collaborations

Petr Kasparek 2 collaborations

Brisa Palikuqi 2 collaborations

Sara Viragova 2 collaborations

Laura Weichselbaum 2 collaborations

Christopher S McGinnis 2 collaborations

Kara L McKinley 2 collaborations

Asoka Rathnayake 2 collaborations

Dedeepya Vaka 2 collaborations

Vinh Nguyen 2 collaborations

Coralie Trentesaux 2 collaborations

Efren Reyes 2 collaborations

Alexander R Gupta 2 collaborations

Zev J Gartner 2 collaborations

Richard M Locksley 2 collaborations

James M Gardner 2 collaborations

Dario Boffelli 2 collaborations

Ronnie Blecher-Gonen 2 collaborations

Eyal David 2 collaborations

Beáta Tóth 2 collaborations

Prisca Liberali 2 collaborations

Hadas Keren-Shaul 2 collaborations

Adi Biram 2 collaborations

Ziv Shulman 2 collaborations

Yael Korem Kohanim 2 collaborations

Oran Yakubovsky 2 collaborations

Yonatan Shapira 1 collaboration

Oluwabunmi Olaloye 1 collaboration

Lael Werner 1 collaboration

Tatiana Silva 1 collaboration

Blake McCourt 1 collaboration

Richard W Pierce 1 collaboration

Jordan S Pober 1 collaboration

Timur Tuganbaev 1 collaboration

Uria Mor 1 collaboration

Stavros Bashiardes 1 collaboration

Timur Liwinski 1 collaboration

Samuel Philip Nobs 1 collaboration

Avner Leshem 1 collaboration

Mally Dori-Bachash 1 collaboration

Christoph A Thaiss 1 collaboration

Elisha Y Pinker 1 collaboration

Karina Ratiner 1 collaboration

Lorenz Adlung 1 collaboration

Sara Federici 1 collaboration

Christian Kleimeyer 1 collaboration

Claudia Moresi 1 collaboration

Takahiro Yamada 1 collaboration

Yotam Cohen 1 collaboration

Xiao Zhang 1 collaboration

Efi Massasa 1 collaboration

Yael Kuperman 1 collaboration

Pandelakis A Koni 1 collaboration

Alon Harmelin 1 collaboration

Nan Gao 1 collaboration

Kenya Honda 1 collaboration

Hagit Shapiro 1 collaboration

Rami Eliakim 1 collaboration

Pierre Bost 1 collaboration

Kerry L Hilligan 1 collaboration

Tomer Meir Salame 1 collaboration

Elsa Roussel 1 collaboration

Lisa M Connor 1 collaboration

Johannes U Mayer 1 collaboration

Benno Schwikowski 1 collaboration

Franca Ronchese 1 collaboration

Jennifer Cable 1 collaboration

Michael B Elowitz 1 collaboration

Ana I Domingos 1 collaboration

Naomi Habib 1 collaboration

Homaira Hamidzada 1 collaboration

Michael S Balzer 1 collaboration

Itai Yanai 1 collaboration

Jessica Whited 1 collaboration

Aaron Streets 1 collaboration

Long Cai 1 collaboration

Andrew B Stergachis 1 collaboration

Clarice Kit Yee Hong 1 collaboration

Leeat Keren 1 collaboration

Martin Guilliams 1 collaboration

Uri Alon 1 collaboration

Alex K Shalek 1 collaboration

Regan Hamel 1 collaboration

Sarah J Pfau 1 collaboration

Arjun Raj 1 collaboration

Stephen R Quake 1 collaboration

Nancy R Zhang 1 collaboration

Jean Fan 1 collaboration

Cole Trapnell 1 collaboration

Bo Wang 1 collaboration

Noah F Greenwald 1 collaboration

Roser Vento-Tormo 1 collaboration

Silvia D M Santos 1 collaboration

Sabrina L Spencer 1 collaboration

Hernan G Garcia 1 collaboration

Geethika Arekatla 1 collaboration

Federico Gaiti 1 collaboration

Rinat Arbel-Goren 1 collaboration

Steffen Rulands 1 collaboration

Jan Philipp Junker 1 collaboration

Allon M Klein 1 collaboration

Samantha A Morris 1 collaboration

John I Murray 1 collaboration

Kate E Galloway 1 collaboration

Michael Ratz 1 collaboration

Merrit Romeike 1 collaboration

Ziv Porat 1 collaboration

Raya Eilam 1 collaboration

Eran Yanowski 1 collaboration

Nancy S Yacovzada 1 collaboration

Amir Giladi 1 collaboration

Diego Jaitin 1 collaboration

Danny Ben-Zvi 1 collaboration

Eran Hornstein 1 collaboration

Donato Inverso 1 collaboration

Jingjing Shi 1 collaboration

Ki Hong Lee 1 collaboration

Moritz Jakab 1 collaboration

Shubhada R Kulkarni 1 collaboration

Martin Schneider 1 collaboration

Guanxiong Wang 1 collaboration

Marziyeh Komeili 1 collaboration

Paula Argos Vélez 1 collaboration

Maria Riedel 1 collaboration

Carleen Spegg 1 collaboration

Thomas Ruppert 1 collaboration

Christine Schaeffer-Reiss 1 collaboration

Dominic Helm 1 collaboration

Indrabahadur Singh 1 collaboration

Michael Boutros 1 collaboration

Sudhakar Chintharlapalli 1 collaboration

Mathias Heikenwalder 1 collaboration

Hellmut G Augustin 1 collaboration

Colas Droin 1 collaboration

Jakob El Kholtei 1 collaboration

Clémence Hurni 1 collaboration

Sapir Muvkadi 1 collaboration

Felix Naef 1 collaboration

Shiri Kult 1 collaboration

Tsviya Olender 1 collaboration

Marco Osterwalder 1 collaboration

Svetalana Markman 1 collaboration

Dena Leshkowitz 1 collaboration

Sharon Krief 1 collaboration

Tomer-Meir Salame 1 collaboration

Terence D Capellini 1 collaboration

Axel Visel 1 collaboration

Elazar Zelzer 1 collaboration

Delfina Papinutti 1 collaboration

Aviezer Lifshitz 1 collaboration

Aleksandra A Kolodziejczyk 1 collaboration

Amichay Afriat 1 collaboration

Vanessa Zuzarte-Luís 1 collaboration

Sofia Marques 1 collaboration

Ângelo Ferreira Chora 1 collaboration

Aparajita Lahree 1 collaboration

Maria M Mota 1 collaboration

Chaya Mushka Abitbol 1 collaboration

Sivan Harnik 1 collaboration

Matan Golan 1 collaboration

Nili Dezorella 1 collaboration

Immacolata Garzilli 1 collaboration

Lior Roitman 1 collaboration

Valery Krizhanovsky 1 collaboration

David Castillo-Azofeifa 1 collaboration

Dan R Miller 1 collaboration

Noa Weinberg-Corem 1 collaboration

Frederic J de Sauvage 1 collaboration

Michal Shoshkes-Carmel 1 collaboration

Eman Khatib-Massalha 1 collaboration

Suditi Bhattacharya 1 collaboration

Karin Golan 1 collaboration

Orit Kollet 1 collaboration

Anju Kumari 1 collaboration

Francesca Avemaria 1 collaboration

Ekaterina Petrovich-Kopitman 1 collaboration

Shiri Gur-Cohen 1 collaboration

Tomer Itkin 1 collaboration

Isabell Brandenburger 1 collaboration

Asaf Spiegel 1 collaboration

Zachary Gerhart-Hines 1 collaboration

Matthias Gunzer 1 collaboration

Stefan Offermanns 1 collaboration

Ronen Alon 1 collaboration

Amiram Ariel 1 collaboration

Tsvee Lapidot 1 collaboration

Hagar Rotem 1 collaboration

Noam Cohen 1 collaboration

Dhana Llivichuzhca-Loja 1 collaboration

Blake T McCourt 1 collaboration

Britta A M Bouwman 1 collaboration

Federico Agostini 1 collaboration

Silvano Garnerone 1 collaboration

Giuseppe Petrosino 1 collaboration

Henrike J Gothe 1 collaboration

Sergi Sayols 1 collaboration

Magda Bienko 1 collaboration

Vassilis Roukos 1 collaboration

Nicola Crosetto 1 collaboration

Samir Abu-Gazala 1 collaboration

Tamar Jana 1 collaboration

Efi E Massasa 1 collaboration

Eli Pikarsky 1 collaboration

Gideon Zamir 1 collaboration

Yiqing Yan 1 collaboration

Deepshika Ramanan 1 collaboration

Kelly McGovern 1 collaboration

Daniella Rastelli 1 collaboration

Brinda Vijaykumar 1 collaboration

Omar Yaghi 1 collaboration

Tiphaine Voisin 1 collaboration

Munir Mosaheb 1 collaboration

Isaac Chiu 1 collaboration

Meenakshi Rao 1 collaboration

Diane Mathis 1 collaboration

Christophe Benoist 1 collaboration

Maria Polychronidou 1 collaboration

Jingyi Hou 1 collaboration

M Madan Babu 1 collaboration

Bart Deplancke 1 collaboration

Galit Lahav 1 collaboration

Matthias Mann 1 collaboration

Julio Saez-Rodriguez 1 collaboration

Fabian Theis 1 collaboration

Roland Eils 1 collaboration

Rouven Hoefflin 1 collaboration

Roy Novoselsky 1 collaboration

Tal Barkai 1 collaboration

Ofra Golani 1 collaboration

Yoseph Addadi 1 collaboration

Merav Kedmi 1 collaboration

Tal Keidar Haran 1 collaboration

Niv Pencovich 1 collaboration

Ron Pery 1 collaboration

Dror S Shouval 1 collaboration

Itay Tirosh 1 collaboration

Ido Nachmany 1 collaboration