Interleukin-6 produced by enteric neurons regulates the number and phenotype of microbe-responsive regulatory T cells in the gut.

Animals Cell Differentiation Cell Proliferation Cells, Cultured Coculture Techniques Enteric Nervous System / immunology Gastrointestinal Microbiome Interleukin-6 / genetics Intestines / immunology Mice Mice, Inbred C57BL Mice, Knockout Neurons / immunology Neurotransmitter Agents / genetics Nuclear Receptor Subfamily 1, Group F, Member 3 / genetics Phenotype T-Lymphocyte Subsets / immunology T-Lymphocytes, Regulatory / immunology
Treg-neuron interactions gut-brain axis neuro-immune interactions regulatory T cells

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
09 03 2021
Historique:
received: 30 01 2020
revised: 02 11 2020
accepted: 05 02 2021
entrez: 10 3 2021
pubmed: 11 3 2021
medline: 14 9 2021
Statut: ppublish

Résumé

The immune and enteric nervous (ENS) systems monitor the frontier with commensal and pathogenic microbes in the colon. We investigated whether FoxP3

Identifiants

DOI: 10.1016/j.immuni.2021.02.002 PMID: 33691135 PMC: PMC8133394
pubmed: 33691135
pii: S1074-7613(21)00068-6
doi: 10.1016/j.immuni.2021.02.002
pmc: PMC8133394
mid: NIHMS1681614
pii:
doi:

Substances chimiques

Interleukin-6 0
Neurotransmitter Agents 0
Nuclear Receptor Subfamily 1, Group F, Member 3 0
Rorc protein, mouse 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

499-513.e5

Subventions

Organisme : NIDDK NIH HHS
ID : K08 DK110532
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK127257
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007753
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI130019
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI125603
Pays : United States
Organisme : NIAID NIH HHS
ID : N01AI30019
Pays : United States
Organisme : NCCIH NIH HHS
ID : DP2 AT009499
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

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Auteurs

Yiqing Yan (Y)

Department of Immunology, Harvard Medical School, Boston MA 02115, USA.

Deepshika Ramanan (D)

Department of Immunology, Harvard Medical School, Boston MA 02115, USA.

Milena Rozenberg (M)

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.

Kelly McGovern (K)

Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.

Daniella Rastelli (D)

Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.

Brinda Vijaykumar (B)

Department of Immunology, Harvard Medical School, Boston MA 02115, USA.

Omar Yaghi (O)

Department of Immunology, Harvard Medical School, Boston MA 02115, USA.

Tiphaine Voisin (T)

Department of Immunology, Harvard Medical School, Boston MA 02115, USA.

Munir Mosaheb (M)

Department of Immunology, Harvard Medical School, Boston MA 02115, USA.

Isaac Chiu (I)

Department of Immunology, Harvard Medical School, Boston MA 02115, USA.

Shalev Itzkovitz (S)

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.

Meenakshi Rao (M)

Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.

Diane Mathis (D)

Department of Immunology, Harvard Medical School, Boston MA 02115, USA.

Christophe Benoist (C)

Department of Immunology, Harvard Medical School, Boston MA 02115, USA. Electronic address: cbdm@hms.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Interleukin-6 produced by enteric neurons...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Interleukin-6 produced by enteric neurons...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Interleukin-6 produced by enteric neurons...
questionsmedicales.fr › Cellules › Cellules cultivées › Interleukin-6 produced by enteric neurons...
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Techniques de culture › Techniques de coculture › Interleukin-6 produced by enteric neurons...
questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Système nerveux autonome › Système nerveux entérique › Interleukin-6 produced by enteric neurons...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › Interleukin-6 produced by enteric neurons...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-6 › Interleukin-6 produced by enteric neurons...
questionsmedicales.fr › Système digestif › Tube digestif › Intestins › Interleukin-6 produced by enteric neurons...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Interleukin-6 produced by enteric neurons...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Interleukin-6 produced by enteric neurons...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Interleukin-6 produced by enteric neurons...
questionsmedicales.fr › Cellules › Neurones › Interleukin-6 produced by enteric neurons...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Interleukin-6 produced by enteric neurons...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Membre-3 du groupe F de la sous-famille-1 de récepteurs nucléaires › Interleukin-6 produced by enteric neurons...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Interleukin-6 produced by enteric neurons...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Interleukin-6 produced by enteric neurons...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Interleukin-6 produced by enteric neurons...