High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
24 Apr 2024
24 Apr 2024
Historique:
received:
10
08
2023
accepted:
09
04
2024
medline:
25
4
2024
pubmed:
25
4
2024
entrez:
24
4
2024
Statut:
epublish
Résumé
Somatic copy number alterations (SCNAs) are pervasive in advanced human cancers, but their prevalence and spatial distribution in early-stage, localized tumors and their surrounding normal tissues are poorly characterized. Here, we perform multi-region, single-cell DNA sequencing to characterize the SCNA landscape across tumor-rich and normal tissue in two male patients with localized prostate cancer. We identify two distinct karyotypes: 'pseudo-diploid' cells harboring few SCNAs and highly aneuploid cells. Pseudo-diploid cells form numerous small-sized subclones ranging from highly spatially localized to broadly spread subclones. In contrast, aneuploid cells do not form subclones and are detected throughout the prostate, including normal tissue regions. Highly localized pseudo-diploid subclones are confined within tumor-rich regions and carry deletions in multiple tumor-suppressor genes. Our study reveals that SCNAs are widespread in normal and tumor regions across the prostate in localized prostate cancer patients and suggests that a subset of pseudo-diploid cells drive tumorigenesis in the aging prostate.
Identifiants
pubmed: 38658552
doi: 10.1038/s41467-024-47664-z
pii: 10.1038/s41467-024-47664-z
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
3475Subventions
Organisme : Cancerfonden (Swedish Cancer Society)
ID : CAN 2018/728
Organisme : Cancerfonden (Swedish Cancer Society)
ID : 19 0130 Pj 03 H
Organisme : Stiftelsen för Strategisk Forskning (Swedish Foundation for Strategic Research)
ID : BD15_0095
Organisme : Stiftelsen för Strategisk Forskning (Swedish Foundation for Strategic Research)
ID : BD15_0095
Informations de copyright
© 2024. The Author(s).
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