Targeting PARP-1 and DNA Damage Response Defects in Colorectal Cancer Chemotherapy with Established and Novel PARP Inhibitors.

DNA damage response PARP-1 chemotherapy colorectal cancer synthetic lethality

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
10 Oct 2024
Historique:
received: 28 08 2024
revised: 28 09 2024
accepted: 07 10 2024
medline: 26 10 2024
pubmed: 26 10 2024
entrez: 26 10 2024
Statut: epublish

Résumé

The DNA repair protein PARP-1 emerged as a valuable target in the treatment of tumor entities with deficiencies of

Identifiants

DOI: 10.3390/cancers16203441 PMID: 39456536
pubmed: 39456536
pii: cancers16203441
doi: 10.3390/cancers16203441
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : INST 248/331-1 FUGG
Organisme : Deutsche Forschungsgemeinschaft
ID : INST 292/161-1 FUGG
Organisme : Wilhelm Sander Stiftung
ID : 2016.039.2

Auteurs

Philipp Demuth (P)

Department of Chemistry, Division of Food Chemistry and Toxicology, RPTU Kaiserslautern-Landau, 67663 Kaiserslautern, Germany.

Lea Thibol (L)

Department of Chemistry, Division of Food Chemistry and Toxicology, RPTU Kaiserslautern-Landau, 67663 Kaiserslautern, Germany.

Anna Lemsch (A)

Department of Chemistry, Division of Food Chemistry and Toxicology, RPTU Kaiserslautern-Landau, 67663 Kaiserslautern, Germany.

Felix Potlitz (F)

Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, University of Greifswald, 17489 Greifswald, Germany.

Lukas Schulig (L)

Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, University of Greifswald, 17489 Greifswald, Germany.
ORCID: 0000-0002-4614-3395

Christoph Grathwol (C)

Institute of Biological and Chemical Systems-Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), 76344 Eggenstein-Leopoldshafen, Germany.
ORCID: 0000-0003-0232-3279

Georg Manolikakes (G)

Department of Chemistry, RPTU Kaiserslautern-Landau, 67663 Kaiserslautern, Germany.
ORCID: 0000-0002-4013-5757

Dennis Schade (D)

Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Christian-Albrechts-University of Kiel, 24118 Kiel, Germany.
ORCID: 0000-0002-5515-1821

Vassilis Roukos (V)

Institute of Molecular Biology, 55128 Mainz, Germany.
ORCID: 0000-0002-5065-3937

Andreas Link (A)

Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, University of Greifswald, 17489 Greifswald, Germany.
ORCID: 0000-0003-1262-6636

Jörg Fahrer (J)

Department of Chemistry, Division of Food Chemistry and Toxicology, RPTU Kaiserslautern-Landau, 67663 Kaiserslautern, Germany.
ORCID: 0000-0001-5225-2718

Classifications MeSH