Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration.

Base Sequence CD4-Positive T-Lymphocytes / metabolism Cell Nucleus / genetics Chromatin / genetics Enhancer Elements, Genetic HIV Infections / genetics HIV-1 / genetics Humans Nuclear Pore / genetics Promoter Regions, Genetic / genetics Transcription, Genetic Virus Integration / genetics

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
06 09 2019
Historique:
received: 11 05 2018
accepted: 19 08 2019
entrez: 8 9 2019
pubmed: 8 9 2019
medline: 31 12 2019
Statut: epublish

Résumé

HIV-1 recurrently targets active genes and integrates in the proximity of the nuclear pore compartment in CD4

Identifiants

DOI: 10.1038/s41467-019-12046-3 PMID: 31492853 PMC: PMC6731298
pubmed: 31492853
doi: 10.1038/s41467-019-12046-3
pii: 10.1038/s41467-019-12046-3
pmc: PMC6731298
doi:

Substances chimiques

Chromatin 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4059

Commentaires et corrections

Type : ErratumIn

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Auteurs

Bojana Lucic (B)

Department of Infectious Diseases, Integrative Virology, Heidelberg University Hospital and German Center for Infection Research, Heidelberg, Germany.

Heng-Chang Chen (HC)

Genome Architecture, Gene Regulation, Stem Cells and Cancer Programme, Center for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Barcelona, Spain.
University Pompeu Fabra, Barcelona, Spain.
ORCID: 0000-0003-2117-7385

Maja Kuzman (M)

Bioinformatics Group, Division of Molecular Biology, Department of Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia.
ORCID: 0000-0002-7490-450X

Eduard Zorita (E)

Genome Architecture, Gene Regulation, Stem Cells and Cancer Programme, Center for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Barcelona, Spain.
University Pompeu Fabra, Barcelona, Spain.
ORCID: 0000-0002-0129-0885

Julia Wegner (J)

Department of Infectious Diseases, Integrative Virology, Heidelberg University Hospital and German Center for Infection Research, Heidelberg, Germany.
Institute for Clinical Chemistry and Clinical Pharmacology, Universitätsklinikum Bonn, Bonn, Germany.

Vera Minneker (V)

Institute of Molecular Biology (IMB), Mainz, Germany.

Wei Wang (W)

German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.

Raffaele Fronza (R)

German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.

Stefanie Laufs (S)

German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.

Manfred Schmidt (M)

German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.

Ralph Stadhouders (R)

Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands.
Department of Cell Biology, Erasmus MC, Rotterdam, The Netherlands.

Vassilis Roukos (V)

Institute of Molecular Biology (IMB), Mainz, Germany.
ORCID: 0000-0002-5065-3937

Kristian Vlahovicek (K)

Bioinformatics Group, Division of Molecular Biology, Department of Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia. kristian@bioinfo.hr.
ORCID: 0000-0002-5705-2464

Guillaume J Filion (GJ)

Genome Architecture, Gene Regulation, Stem Cells and Cancer Programme, Center for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Barcelona, Spain. guillaume.filion@gmail.com.
University Pompeu Fabra, Barcelona, Spain. guillaume.filion@gmail.com.
Department of Biological Sciences, University of Toronto Scarborough, Toronto, ON, Canada. guillaume.filion@gmail.com.
ORCID: 0000-0002-3473-1632

Marina Lusic (M)

Department of Infectious Diseases, Integrative Virology, Heidelberg University Hospital and German Center for Infection Research, Heidelberg, Germany. Marina.lusic@med.uni-heidelberg.de.
ORCID: 0000-0002-0120-3569

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence nucléotidique › Spatially clustered loci with multiple...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Spatially clustered loci with multiple...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Noyau de la cellule › Spatially clustered loci with multiple...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Spatially clustered loci with multiple...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Éléments activateurs (génétique) › Spatially clustered loci with multiple...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Spatially clustered loci with multiple...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › Spatially clustered loci with multiple...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Spatially clustered loci with multiple...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Structures nucléaires › Pore nucléaire › Spatially clustered loci with multiple...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Régions promotrices (génétique) › Spatially clustered loci with multiple...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Transcription génétique › Spatially clustered loci with multiple...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Intégration virale › Spatially clustered loci with multiple...