53BP1-DNA repair enters a new liquid phase.
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
15 08 2019
15 08 2019
Historique:
pubmed:
30
7
2019
medline:
18
12
2019
entrez:
30
7
2019
Statut:
ppublish
Résumé
In response to DNA damage, transient repair compartments in the nucleus concentrate repair proteins and activate downstream signaling factors. In this issue of The EMBO Journal, Kilic et al show that DNA repair focal assemblies marked by accumulation of 53BP1 are phase separated liquid compartments. This liquid droplet-like behavior of 53BP1 compartments might help to coordinate local lesion recognition with global gene activation in response to DNA damage.
Identifiants
pubmed: 31355472
doi: 10.15252/embj.2019102871
pmc: PMC6694213
doi:
Substances chimiques
Intracellular Signaling Peptides and Proteins
0
Tumor Suppressor p53-Binding Protein 1
0
Types de publication
Journal Article
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
e102871Commentaires et corrections
Type : CommentOn
Informations de copyright
© 2019 The Authors.
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