Techniques for investigating mitochondrial gene expression.
Animals
Clustered Regularly Interspaced Short Palindromic Repeats
/ genetics
DNA, Mitochondrial
/ genetics
Humans
In Situ Hybridization, Fluorescence
MicroRNAs
/ genetics
Mitochondrial Proteins
/ chemistry
Protein Biosynthesis
/ drug effects
RNA, Mitochondrial
/ metabolism
Transcription Activator-Like Effector Nucleases
/ metabolism
Transcription, Genetic
Journal
BMB reports
ISSN: 1976-670X
Titre abrégé: BMB Rep
Pays: Korea (South)
ID NLM: 101465334
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
25
09
2019
pubmed:
11
12
2019
medline:
15
5
2020
entrez:
11
12
2019
Statut:
ppublish
Résumé
The mitochondrial genome encodes 13 proteins that are components of the oxidative phosphorylation system (OXPHOS), suggesting that precise regulation of these genes is crucial for maintaining OXPHOS functions, including ATP production, calcium buffering, cell signaling, ROS production, and apoptosis. Furthermore, heteroplasmy or mis-regulation of gene expression in mitochondria frequently is associated with human mitochondrial diseases. Thus, various approaches have been developed to investigate the roles of genes encoded by the mitochondrial genome. In this review, we will discuss a wide range of techniques available for investigating the mitochondrial genome, mitochondrial transcription, and mitochondrial translation, which provide a useful guide to understanding mitochondrial gene expression. [BMB Reports 2020; 53(1): 3-9].
Substances chimiques
DNA, Mitochondrial
0
MicroRNAs
0
Mitochondrial Proteins
0
RNA, Mitochondrial
0
Transcription Activator-Like Effector Nucleases
EC 3.1.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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