Identification of Drug Resistance Determinants in a Clinical Isolate of Pseudomonas aeruginosa by High-Density Transposon Mutagenesis.
Anti-Bacterial Agents
/ pharmacology
Bacterial Proteins
/ genetics
Cefepime
/ pharmacology
DNA Transposable Elements
Drug Resistance, Multiple, Bacterial
/ genetics
Endopeptidases
/ deficiency
Gene Deletion
Gene Expression Regulation, Bacterial
Glycosyltransferases
/ deficiency
Humans
Meropenem
/ pharmacology
Microbial Sensitivity Tests
Mutagenesis
Phosphotransferases (Alcohol Group Acceptor)
/ deficiency
Pseudomonas Infections
/ drug therapy
Pseudomonas aeruginosa
/ drug effects
beta-Lactam Resistance
/ genetics
beta-Lactamases
/ genetics
AmpC β-lactamase
Pseudomonas aeruginosa
TraDIS
antibiotics
clinical isolate
multidrug resistance
peptidoglycan
peptidoglycan recycling
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
21 02 2020
21 02 2020
Historique:
received:
09
09
2019
accepted:
25
11
2019
pubmed:
11
12
2019
medline:
19
12
2020
entrez:
11
12
2019
Statut:
epublish
Résumé
With the aim to identify potential new targets to restore antimicrobial susceptibility of multidrug-resistant (MDR)
Identifiants
pubmed: 31818817
pii: AAC.01771-19
doi: 10.1128/AAC.01771-19
pmc: PMC7038268
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacterial Proteins
0
DNA Transposable Elements
0
Cefepime
807PW4VQE3
Glycosyltransferases
EC 2.4.-
Phosphotransferases (Alcohol Group Acceptor)
EC 2.7.1.-
N-acetylglucosamine kinase
EC 2.7.1.59
Endopeptidases
EC 3.4.-
AmpC beta-lactamases
EC 3.5.2.6
beta-Lactamases
EC 3.5.2.6
Meropenem
FV9J3JU8B1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 Sonnabend et al.
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