Mitochondrial 4-HNE derived from MAO-A promotes mitoCa
Journal
Cell death and differentiation
ISSN: 1476-5403
Titre abrégé: Cell Death Differ
Pays: England
ID NLM: 9437445
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
31
05
2019
accepted:
25
11
2019
revised:
25
11
2019
pubmed:
11
12
2019
medline:
9
9
2021
entrez:
11
12
2019
Statut:
ppublish
Résumé
Chronic remodeling postmyocardial infarction consists in various maladaptive changes including interstitial fibrosis, cardiomyocyte death and mitochondrial dysfunction that lead to heart failure (HF). Reactive aldehydes such as 4-hydroxynonenal (4-HNE) are critical mediators of mitochondrial dysfunction but the sources of mitochondrial 4-HNE in cardiac diseases together with its mechanisms of action remain poorly understood. Here, we evaluated whether the mitochondrial enzyme monoamine oxidase-A (MAO-A), which generates H
Identifiants
pubmed: 31819159
doi: 10.1038/s41418-019-0470-y
pii: 10.1038/s41418-019-0470-y
pmc: PMC7244724
doi:
Substances chimiques
Aldehydes
0
Monoamine Oxidase
EC 1.4.3.4
monoamine oxidase A, human
EC 1.4.3.4.
4-hydroxy-2-nonenal
K1CVM13F96
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1907-1923Références
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