Expression of deubiquitinating enzyme genes in the developing mammal retina.
Journal
Molecular vision
ISSN: 1090-0535
Titre abrégé: Mol Vis
Pays: United States
ID NLM: 9605351
Informations de publication
Date de publication:
2019
2019
Historique:
received:
07
06
2019
accepted:
29
11
2019
entrez:
11
12
2019
pubmed:
11
12
2019
medline:
20
6
2020
Statut:
epublish
Résumé
Genes involved in the development and differentiation of the mammalian retina are also associated with inherited retinal dystrophies (IRDs) and age-related macular degeneration. Transcriptional regulation of retinal cell differentiation has been addressed by genetic and transcriptomic studies. Much less is known about the posttranslational regulation of key regulatory proteins, although mutations in some genes involved in ubiquitination and proteostasis-E3 ligases and deubiquitinating enzymes (DUBs)-cause IRDs. This study intends to provide new data on DUB gene expression during different developmental stages of mouse and human fetal retinas. We performed a comprehensive transcriptomic analysis of all the annotated human and mouse DUBs (87) in the developing mouse retina at several embryonic and postnatal time points compared with the transcriptome of the fetal human retina. An integrated comparison of data from transcriptomics, reported chromatin immunoprecipitation sequencing (ChIP-seq) of CRX and NRL transcription factors, and the phenotypic retinal alterations in different animal models is presented. Several DUB genes are differentially expressed during the development of the mouse and human retinas in relation to proliferation or differentiation stages. Some DUB genes appear to be distinctly expressed during the differentiation stages of rod and cone photoreceptor cells, and their expression is altered in mouse knockout models of relevant photoreceptor transcription factors. We complemented this RNA-sequencing (RNA-seq) analysis with other reported expression and phenotypic data to underscore the involvement of DUBs in cell fate decision and photoreceptor differentiation. The present results highlight a short list of potential DUB candidates for retinal disorders, which require further study.
Substances chimiques
Deubiquitinating Enzymes
EC 3.4.19.12
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
800-813Informations de copyright
Copyright © 2019 Molecular Vision.
Références
Nat Genet. 2001 Dec;29(4):447-52
pubmed: 11694879
Am J Hum Genet. 2007 Nov;81(5):1098-103
pubmed: 17924349
Nat Genet. 1999 Dec;23(4):466-70
pubmed: 10581037
Cell. 2015 May 21;161(5):1202-1214
pubmed: 26000488
Mol Cell. 2007 Feb 23;25(4):615-24
pubmed: 17317632
J Neurochem. 2015 Sep;134(6):1067-80
pubmed: 26077708
J Neurosci Res. 2019 Jan;97(1):16-28
pubmed: 30260491
Stem Cells. 2019 May;37(5):593-598
pubmed: 30548510
Genome Res. 2010 Nov;20(11):1512-25
pubmed: 20693478
Curr Opin Cell Biol. 2007 Apr;19(2):199-205
pubmed: 17303403
Exp Eye Res. 2008 Nov;87(5):415-26
pubmed: 18778702
PLoS Genet. 2012;8(4):e1002649
pubmed: 22511886
Nat Commun. 2018 Aug 9;9(1):3171
pubmed: 30093687
Hum Mol Genet. 2006 Sep 1;15(17):2588-602
pubmed: 16868010
Hum Mol Genet. 2018 Oct 1;27(19):3325-3339
pubmed: 30239781
Nat Commun. 2018 Jun 11;9(1):2280
pubmed: 29891926
Nat Commun. 2018 Feb 22;9(1):758
pubmed: 29472535
Development. 2015 Oct 1;142(19):3263-73
pubmed: 26443631
Stem Cell Reports. 2018 Apr 10;10(4):1282-1293
pubmed: 29576537
FEBS Lett. 2017 Mar;591(6):875-888
pubmed: 28140449
Brain Res. 2008 Oct 21;1236:16-29
pubmed: 18294621
J Neurosci. 2011 Aug 3;31(31):11118-25
pubmed: 21813673
Dev Cell. 2017 Dec 18;43(6):763-779.e4
pubmed: 29233477
Physiol Rev. 2013 Jul;93(3):1289-315
pubmed: 23899565
PLoS One. 2016 Mar 02;11(3):e0150364
pubmed: 26934049
Am J Hum Genet. 2009 Jun;84(6):792-800
pubmed: 19520207
Arch Ophthalmol. 2010 Jun;128(6):772-8
pubmed: 20547956
J Biol Chem. 2010 Aug 13;285(33):25637-44
pubmed: 20551322
BMC Genomics. 2009 Dec 30;10:637
pubmed: 20040115
Nat Rev Neurosci. 2010 Aug;11(8):563-76
pubmed: 20648062
Methods Mol Biol. 2016;1449:85-101
pubmed: 27613029
Mol Cell. 2016 Jul 7;63(1):146-55
pubmed: 27292798
Development. 2000 Apr;127(8):1727-36
pubmed: 10725248
Arch Ophthalmol. 2011 Nov;129(11):1475-82
pubmed: 22084217
Brain Res. 2008 Feb 4;1192:114-33
pubmed: 17662965
Neuron. 2009 Jan 29;61(2):234-46
pubmed: 19186166
Invest Ophthalmol Vis Sci. 2003 May;44(5):2171-7
pubmed: 12714658
Cell Tissue Res. 2012 Jun;348(3):453-63
pubmed: 22526625
Mol Vis. 2008 May 19;14:922-7
pubmed: 18509552
Annu Rev Biochem. 2012;81:291-322
pubmed: 22482907
Cell Rep. 2016 Nov 22;17(9):2460-2473
pubmed: 27880916
Biol Open. 2017 Jun 15;6(6):881-890
pubmed: 28495965
Mol Neurobiol. 2013 Apr;47(2):790-810
pubmed: 23339020
J Clin Invest. 2014 Feb;124(2):631-43
pubmed: 24382353
J Med Genet. 2019 May;56(5):325-331
pubmed: 30573563
Annu Rev Genet. 1996;30:405-39
pubmed: 8982460