Interleukin-15 (dys)regulation of lymphoid homeostasis: Implications for therapy of autoimmunity and cancer.
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
06 01 2020
06 01 2020
Historique:
received:
13
06
2019
revised:
30
08
2019
accepted:
30
10
2019
entrez:
11
12
2019
pubmed:
11
12
2019
medline:
14
7
2020
Statut:
ppublish
Résumé
IL-15, a pleiotropic cytokine, stimulates generation of NK, NK-T, γδ, ILC1, and memory CD8 T cells. IL-15 disorders play pathogenetic roles in organ-specific autoimmune diseases including celiac disease. Diverse approaches are developed to block IL-15 action. IL-15 administered to patients with malignancy yielded dramatic increases in NK numbers and modest increases in CD8 T cells. Due to immunological checkpoints, to achieve major cancer therapeutic efficacy, IL-15 will be used in combination therapy, and combination trials with checkpoint inhibitors, with anti-CD40 to yield tumor-specific CD8 T cells, and with anticancer monoclonal antibodies to increase ADCC and antitumor efficacy, have been initiated.
Identifiants
pubmed: 31821442
pii: 132622
doi: 10.1084/jem.20191062
pmc: PMC7037239
pii:
doi:
Substances chimiques
Antibodies, Monoclonal
0
Interleukin-15
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
This is a work of the U.S. Government and is not subject to copyright protection in the United States. Foreign copyrights may apply.
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