Chronic corticosterone administration induces negative valence and impairs positive valence behaviors in mice.


Journal

Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664

Informations de publication

Date de publication:
10 12 2019
Historique:
received: 16 05 2019
accepted: 21 11 2019
revised: 11 11 2019
entrez: 12 12 2019
pubmed: 12 12 2019
medline: 22 9 2020
Statut: epublish

Résumé

Behavioral approaches utilizing rodents to study mood disorders have focused primarily on negative valence behaviors associated with potential threat (anxiety-related behaviors). However, for disorders such as depression, positive valence behaviors that assess reward processing may be more translationally valid and predictive of antidepressant treatment outcome. Chronic corticosterone (CORT) administration is a well-validated pharmacological stressor that increases avoidance in negative valence behaviors associated with anxiety

Identifiants

pubmed: 31822658
doi: 10.1038/s41398-019-0674-4
pii: 10.1038/s41398-019-0674-4
pmc: PMC6904464
doi:

Substances chimiques

Steroids 0
Corticosterone W980KJ009P

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

337

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH112861
Pays : United States

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Auteurs

Andrew Dieterich (A)

Neuroscience Graduate Program, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.
Department of Psychology, Behavioral and Systems Neuroscience Area, Rutgers, The State University of New Jersey, 152 Frelinghuysen Rd, Piscataway, NJ, 08854, USA.

Prachi Srivastava (P)

Department of Psychology, Behavioral and Systems Neuroscience Area, Rutgers, The State University of New Jersey, 152 Frelinghuysen Rd, Piscataway, NJ, 08854, USA.

Aitesam Sharif (A)

Department of Psychology, Behavioral and Systems Neuroscience Area, Rutgers, The State University of New Jersey, 152 Frelinghuysen Rd, Piscataway, NJ, 08854, USA.

Karina Stech (K)

Department of Psychology, Behavioral and Systems Neuroscience Area, Rutgers, The State University of New Jersey, 152 Frelinghuysen Rd, Piscataway, NJ, 08854, USA.

Joseph Floeder (J)

Department of Psychology, Behavioral and Systems Neuroscience Area, Rutgers, The State University of New Jersey, 152 Frelinghuysen Rd, Piscataway, NJ, 08854, USA.

Samantha E Yohn (SE)

Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.

Benjamin A Samuels (BA)

Neuroscience Graduate Program, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA. ben.samuels@rutgers.edu.
Department of Psychology, Behavioral and Systems Neuroscience Area, Rutgers, The State University of New Jersey, 152 Frelinghuysen Rd, Piscataway, NJ, 08854, USA. ben.samuels@rutgers.edu.

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Classifications MeSH