The Role of Deubiquitinases in Vascular Diseases.


Journal

Journal of cardiovascular translational research
ISSN: 1937-5395
Titre abrégé: J Cardiovasc Transl Res
Pays: United States
ID NLM: 101468585

Informations de publication

Date de publication:
04 2020
Historique:
received: 03 07 2019
accepted: 21 08 2019
pubmed: 12 12 2019
medline: 8 10 2020
entrez: 12 12 2019
Statut: ppublish

Résumé

Deubiquitinases (DUBs) are a major component of the ubiquitin-proteasome system in eukaryotic cells; the system plays a crucial role in many biological processes, such as inflammation, oxidative stress, and cell apoptosis, which are important in vascular biology and pathology. DUBs have drawn significant attention in recent years, and their function is increasingly linked with vascular diseases. In this review, we summarize the indirect and direct evidence for the effects of DUBs on atherosclerosis, abdominal aortic aneurysm, angiogenesis, and hypertension, and point out pathways that could be pursued for investigating DUBs. Intervention in the function of DUBs in vascular diseases has potential therapeutic value.

Identifiants

pubmed: 31823221
doi: 10.1007/s12265-019-09909-x
pii: 10.1007/s12265-019-09909-x
doi:

Substances chimiques

Deubiquitinating Enzymes EC 3.4.19.12
Lysine K3Z4F929H6

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

131-141

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Auteurs

Biqing Wang (B)

Key Laboratory of Immune Microenvironment and Disease (Ministry of Education) and Department of Physiology and Pathophysiology Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University, Tianjin, 300070, China.

Wenbin Cai (W)

Key Laboratory of Immune Microenvironment and Disease (Ministry of Education) and Department of Physiology and Pathophysiology Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University, Tianjin, 300070, China.

Ding Ai (D)

Key Laboratory of Immune Microenvironment and Disease (Ministry of Education) and Department of Physiology and Pathophysiology Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University, Tianjin, 300070, China.

Xu Zhang (X)

Key Laboratory of Immune Microenvironment and Disease (Ministry of Education) and Department of Physiology and Pathophysiology Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University, Tianjin, 300070, China. xuzhang@tmu.edu.cn.

Liu Yao (L)

Key Laboratory of Immune Microenvironment and Disease (Ministry of Education) and Department of Physiology and Pathophysiology Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University, Tianjin, 300070, China. yaoliu@tmu.edu.cn.

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Classifications MeSH