Role of a new bioassay for thyroid-stimulating antibodies (aequorin TSAb) in Graves' ophthalmopathy.
Aequorin
Graves’ ophthalmopathy
Thyroid-stimulating antibody
Thyrotropin receptor antibody
Journal
Endocrine journal
ISSN: 1348-4540
Titre abrégé: Endocr J
Pays: Japan
ID NLM: 9313485
Informations de publication
Date de publication:
28 Mar 2020
28 Mar 2020
Historique:
pubmed:
13
12
2019
medline:
7
1
2021
entrez:
13
12
2019
Statut:
ppublish
Résumé
Graves' ophthalmopathy (GO) is characterized by an autoimmune reaction against thyrotropin (TSH) receptors and is diagnosed by TSH receptor antibody (TRAb). A novel assay for thyroid-stimulating antibody (TSAb) was recently introduced using a frozen Chinese hamster ovary cell line expressing TSH receptors, cyclic adenosine monophosphate (cAMP)-gated calcium channel, and aequorin (aequorin TSAb). The aim of this study was to evaluate the role of aequorin TSAb in GO. We studied 136 Japanese patients with GO (22 euthyroid and 8 hypothyroid GO patients) at our hospital. TRAbs were estimated by first generation TRAb (TRAb 1
Identifiants
pubmed: 31827052
doi: 10.1507/endocrj.EJ19-0398
doi:
Substances chimiques
Immunoglobulins, Thyroid-Stimulating
0
Aequorin
50934-79-7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM