Intracellular sensing of viral genomes and viral evasion.
Journal
Experimental & molecular medicine
ISSN: 2092-6413
Titre abrégé: Exp Mol Med
Pays: United States
ID NLM: 9607880
Informations de publication
Date de publication:
11 12 2019
11 12 2019
Historique:
received:
25
03
2019
accepted:
22
05
2019
revised:
15
05
2019
entrez:
13
12
2019
pubmed:
13
12
2019
medline:
17
6
2020
Statut:
epublish
Résumé
During viral infection, virus-derived cytosolic nucleic acids are recognized by host intracellular specific sensors. The efficacy of this recognition system is crucial for triggering innate host defenses, which then stimulate more specific adaptive immune responses against the virus. Recent studies show that signal transduction pathways activated by sensing proteins are positively or negatively regulated by many modulators to maintain host immune homeostasis. However, viruses have evolved several strategies to counteract/evade host immune reactions. These systems involve viral proteins that interact with host sensor proteins and prevent them from detecting the viral genome or from initiating immune signaling. In this review, we discuss key regulators of cytosolic sensor proteins and viral proteins based on experimental evidence.
Identifiants
pubmed: 31827068
doi: 10.1038/s12276-019-0299-y
pii: 10.1038/s12276-019-0299-y
pmc: PMC6906418
doi:
Substances chimiques
Receptors, Immunologic
0
DHX58 protein, human
EC 2.7.7.-
RIGI protein, human
EC 3.6.1.-
IFIH1 protein, human
EC 3.6.1.-
DEAD Box Protein 58
EC 3.6.4.13
Interferon-Induced Helicase, IFIH1
EC 3.6.4.13
RNA Helicases
EC 3.6.4.13
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-13Subventions
Organisme : National Research Foundation of Korea (NRF)
ID : 2018M3A9H4079660
Pays : International
Organisme : National Research Foundation of Korea (NRF)
ID : 2018M3A9H4078703
Pays : International
Organisme : National Research Foundation of Korea (NRF)
ID : 2019R1A2C2008283
Pays : International
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