Urinary Metabolomic Markers of Protein Glycation, Oxidation, and Nitration in Early-Stage Decline in Metabolic, Vascular, and Renal Health.
Adult
Algorithms
Amino Acids, Branched-Chain
/ metabolism
Biomarkers
/ urine
Body Mass Index
Case-Control Studies
Chromatography, High Pressure Liquid
Female
Glycation End Products, Advanced
/ urine
Glycosylation
Humans
Kidney
/ metabolism
Lysine
/ analogs & derivatives
Male
Metabolic Diseases
/ metabolism
Oxidation-Reduction
Severity of Illness Index
Tandem Mass Spectrometry
Tyrosine
/ analogs & derivatives
Vascular Diseases
/ metabolism
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2019
2019
Historique:
received:
23
05
2019
revised:
07
09
2019
accepted:
11
09
2019
entrez:
13
12
2019
pubmed:
13
12
2019
medline:
28
4
2020
Statut:
epublish
Résumé
Glycation, oxidation, nitration, and crosslinking of proteins are implicated in the pathogenic mechanisms of type 2 diabetes, cardiovascular disease, and chronic kidney disease. Related modified amino acids formed by proteolysis are excreted in urine. We quantified urinary levels of these metabolites and branched-chain amino acids (BCAAs) in healthy subjects and assessed changes in early-stage decline in metabolic, vascular, and renal health and explored their diagnostic utility for a noninvasive health screen. We recruited 200 human subjects with early-stage health decline and healthy controls. Urinary amino acid metabolites were determined by stable isotopic dilution analysis liquid chromatography-tandem mass spectrometry. Machine learning was applied to optimise and validate algorithms to discriminate between study groups for potential diagnostic utility. Urinary analyte changes were as follows: impaired metabolic health-increased N
Identifiants
pubmed: 31827677
doi: 10.1155/2019/4851323
pmc: PMC6885816
doi:
Substances chimiques
Amino Acids, Branched-Chain
0
Biomarkers
0
Glycation End Products, Advanced
0
3-nitrotyrosine
3604-79-3
Tyrosine
42HK56048U
glucosepane
66K23JT22H
N(6)-carboxymethyllysine
70YDX3Z2O7
Lysine
K3Z4F929H6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4851323Informations de copyright
Copyright © 2019 Jinit Masania et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflict of interest in relation to this work.
Références
Nat Rev Endocrinol. 2014 Dec;10(12):723-36
pubmed: 25287287
J Nutr. 2006 Jan;136(1 Suppl):299S-307S
pubmed: 16365103
Trends Biochem Sci. 2016 Aug;41(8):654-664
pubmed: 27426990
Arterioscler Thromb Vasc Biol. 2004 May;24(5):816-23
pubmed: 14976002
Nutrients. 2019 May 16;11(5):null
pubmed: 31100942
J Am Soc Echocardiogr. 2008 Feb;21(2):93-111; quiz 189-90
pubmed: 18261694
J Clin Endocrinol Metab. 2015 Mar;100(3):902-10
pubmed: 25532041
Semin Dial. 2009 Jul-Aug;22(4):405-8
pubmed: 19708991
Am J Kidney Dis. 2011 Mar;57(3 Suppl 2):S17-23
pubmed: 21338846
Diabetologia. 2005 Aug;48(8):1590-603
pubmed: 15988580
Transl Res. 2013 Sep;162(3):191-200
pubmed: 23810582
Diabetes. 1991 Feb;40(2):190-6
pubmed: 1899406
Biochem J. 2003 Nov 1;375(Pt 3):581-92
pubmed: 12885296
Biochem Soc Trans. 2014 Apr;42(2):511-7
pubmed: 24646270
J Nutr Sci Vitaminol (Tokyo). 1990;36 Suppl 1:S71-7
pubmed: 1982012
Metabolites. 2019 Jul 25;9(8):null
pubmed: 31349624
Nat Clin Pract Endocrinol Metab. 2008 Jul;4(7):382-93
pubmed: 18493227
Nahrung. 2001 Jun;45(3):177-81
pubmed: 11455784
Biochem Biophys Res Commun. 2015 Mar 6;458(2):221-6
pubmed: 25666945
Ann Intern Med. 1999 Mar 16;130(6):461-70
pubmed: 10075613
Circulation. 2007 Jan 30;115(4):459-67
pubmed: 17242284
J Neuroimaging. 1991 Nov;1(4):168-72
pubmed: 10149810
J Agric Food Chem. 2005 Apr 20;53(8):2830-7
pubmed: 15826026
Atherosclerosis. 2009 Aug;205(2):590-4
pubmed: 19185865
Biochim Biophys Acta. 2014 Feb;1840(2):818-29
pubmed: 23558060
Amino Acids. 2012 Jan;42(1):45-63
pubmed: 20495837
Kidney Int. 2009 Aug;76(4):363-5
pubmed: 19644479
J Am Soc Nephrol. 2005 May;16(5):1471-85
pubmed: 15800128
Mol Nutr Food Res. 2009 Jul;53(7):795-804
pubmed: 19517455
Int J Epidemiol. 2019 Jun 1;48(3):978-993
pubmed: 30689875
Circulation. 2012 May 8;125(18):2222-31
pubmed: 22496159
Kidney Int. 2007 Nov;72(9):1113-21
pubmed: 17728703
Annu Rev Biomed Eng. 2006;8:537-65
pubmed: 16834566
Lancet. 2012 Dec 15;380(9859):2224-60
pubmed: 23245609
J Biol Chem. 2004 Jun 25;279(26):27613-20
pubmed: 15102834
Diabetes. 2016 Aug;65(8):2282-94
pubmed: 27207552
Metabolomics. 2013 Apr;9(2):280-299
pubmed: 23543913
Cell Metab. 2009 Apr;9(4):311-26
pubmed: 19356713
J Neurosci Methods. 2009 Oct 30;184(1):136-41
pubmed: 19631689
Kidney Int Suppl. 2007 Aug;(106):S17-26
pubmed: 17653206
J Cell Biol. 2001 Aug 20;154(4):879-91
pubmed: 11514595
Biochem Soc Trans. 2003 Dec;31(Pt 6):1383-5
pubmed: 14641068
Diabetes Care. 2005 Oct;28(10):2465-71
pubmed: 16186281
Chem Res Toxicol. 2006 Aug;19(8):1059-65
pubmed: 16918245
Diabetes Care. 2018 Jan;41(Suppl 1):S13-S27
pubmed: 29222373
J Bacteriol. 2001 Dec;183(24):7165-72
pubmed: 11717275
Nat Rev Mol Cell Biol. 2003 Feb;4(2):140-56
pubmed: 12563291
Horm Metab Res. 2012 Dec;44(13):938-42
pubmed: 23015612
Kidney Int. 2007 Feb;71(3):266-71
pubmed: 17149371
Bioorg Med Chem. 1999 Jun;7(6):1081-8
pubmed: 10428377
Lancet. 2005 Apr 23-29;365(9469):1500-5
pubmed: 15850636
Diabetes. 2001 Sep;50(9):2139-47
pubmed: 11522682
J Biol Chem. 2002 Jul 12;277(28):24907-15
pubmed: 11978796
Atherosclerosis. 2000 Feb;148(2):297-302
pubmed: 10657565
Biofactors. 2018 May;44(3):281-288
pubmed: 29718545
J Hepatol. 2004 Dec;41(6):913-9
pubmed: 15582123
Diabetologia. 1985 Jul;28(7):412-9
pubmed: 3899825
Kidney Int. 2018 Apr;93(4):803-813
pubmed: 29477239
Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):69-74
pubmed: 11120890
J Agric Food Chem. 2017 Feb 1;65(4):930-937
pubmed: 28112514
BMC Cardiovasc Disord. 2017 Jan 28;17(1):44
pubmed: 28129745
J Clin Endocrinol Metab. 2013 Aug;98(8):E1369-73
pubmed: 23780372
Miner Electrolyte Metab. 1993;19(1):25-31
pubmed: 8345831
Diabetes Care. 2007 Nov;30(11):2874-9
pubmed: 17698614
Ren Fail. 2017 Nov;39(1):452-457
pubmed: 28372505
BMJ. 2010 Nov 08;341:c5869
pubmed: 21059726
Sci Rep. 2018 Jan 10;8(1):245
pubmed: 29321582