Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients.
Adult
Akkermansia
Animals
Asthma
/ complications
Disease Models, Animal
Feces
/ microbiology
Female
Forced Expiratory Volume
Gastrointestinal Microbiome
/ immunology
Healthy Volunteers
Host Microbial Interactions
/ immunology
Humans
Male
Mice
Middle Aged
Obesity
/ complications
Respiratory System
/ immunology
Severity of Illness Index
Verrucomicrobia
/ immunology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
13 12 2019
13 12 2019
Historique:
received:
05
03
2019
accepted:
13
11
2019
entrez:
15
12
2019
pubmed:
15
12
2019
medline:
3
4
2020
Statut:
epublish
Résumé
In order to improve targeted therapeutic approaches for asthma patients, insights into the molecular mechanisms that differentially contribute to disease phenotypes, such as obese asthmatics or severe asthmatics, are required. Here we report immunological and microbiome alterations in obese asthmatics (n = 50, mean age = 45), non-obese asthmatics (n = 53, mean age = 40), obese non-asthmatics (n = 51, mean age = 44) and their healthy counterparts (n = 48, mean age = 39). Obesity is associated with elevated proinflammatory signatures, which are enhanced in the presence of asthma. Similarly, obesity or asthma induced changes in the composition of the microbiota, while an additive effect is observed in obese asthma patients. Asthma disease severity is negatively correlated with fecal Akkermansia muciniphila levels. Administration of A. muciniphila to murine models significantly reduces airway hyper-reactivity and airway inflammation. Changes in immunological processes and microbiota composition are accentuated in obese asthma patients due to the additive effects of both disease states, while A. muciniphila may play a non-redundant role in patients with a severe asthma phenotype.
Identifiants
pubmed: 31836714
doi: 10.1038/s41467-019-13751-9
pii: 10.1038/s41467-019-13751-9
pmc: PMC6911092
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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