Trichothioneic acid, a new antioxidant compound produced by the fungal strain Trichoderma virens FKI-7573.

Antioxidants / isolation & purification Dose-Response Relationship, Drug Free Radical Scavengers / isolation & purification Gas Chromatography-Mass Spectrometry Hypocrea / classification Mass Spectrometry Microbiological Techniques Trichoderma / growth & development
Ergothioneine Hydroxyl radical Mass spectrometry Singlet oxygen Trichoderma virens Trichothioneic acid

Journal

Journal of bioscience and bioengineering
ISSN: 1347-4421
Titre abrégé: J Biosci Bioeng
Pays: Japan
ID NLM: 100888800

Informations de publication

Date de publication:
Apr 2020
Historique:
received: 20 08 2019
revised: 08 10 2019
accepted: 13 11 2019
pubmed: 16 12 2019
medline: 9 6 2020
entrez: 16 12 2019
Statut: ppublish

Résumé

A new nitrogen-containing compound, trichothioneic acid, was discovered from the metabolites of fungal strain FKI-7573 using a mass spectrometry screening method guided by odd number of molecular weights, which indicates compounds that contain an odd number of nitrogen atoms. Strain FKI-7573 was isolated from soil collected in Obihiro, Hokkaido, Japan, and identified as Trichoderma virens by a sequence analysis of the internal transcribed spacer region, including 5.8S ribosomal RNA. The structure of trichothioneic acid was determined by mass spectrometry, nuclear magnetic resonance spectroscopy, electronic circular dichroism spectra, and chemical degradation analyses. These analyses revealed that trichothioneic acid consists of heptelidic acid and l-ergothioneine, and contains three nitrogen atoms. Trichothioneic acid exhibited hydroxyl radical-scavenging and singlet oxygen-quenching activities.

Identifiants

DOI: 10.1016/j.jbiosc.2019.11.007 PMID: 31837993
pubmed: 31837993
pii: S1389-1723(19)30826-6
doi: 10.1016/j.jbiosc.2019.11.007
pii:
doi:

Substances chimiques

Antioxidants 0
Free Radical Scavengers 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

508-513

Informations de copyright

Copyright © 2019 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

Auteurs

Rei Miyano (R)

Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.

Hirotaka Matsuo (H)

Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan; Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.

Takayuki Mokudai (T)

Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai 980-8775, Japan.

Yoshihiko Noguchi (Y)

Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan; Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.

Mayuka Higo (M)

Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.

Kenichi Nonaka (K)

Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan; Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.

Yoshimi Niwano (Y)

Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai 980-8775, Japan.

Toshiaki Sunazuka (T)

Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan; Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.

Kazuro Shiomi (K)

Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan; Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.

Yōko Takahashi (Y)

Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.

Satoshi Ōmura (S)

Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.

Takuji Nakashima (T)

Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan; Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan. Electronic address: takuji@lisci.kitasato-u.ac.jp.

Articles similaires

Enhancing strawberry resilience to saline, alkaline, and combined stresses with light spectra: impacts on growth, enzymatic activity, nutrient uptake, and osmotic regulation.

Mohammad Reza Malekzadeh, Hamid Reza Roosta, Hazem M Kalaji
1.00
Fragaria Light Plant Leaves Osmosis Stress, Physiological

Unveiling the influences of P fertilization on bioactive compounds and antioxidant activity in grains of four sorghum cultivars.

Mohammed Elsafy, Nouralhuda A J Tia, Khitma A Sir Elkhatim et al.
1.00
Sorghum Antioxidants Phosphorus Fertilizers Flavonoids

Effects of intensive and conventional farming on oxidative stress and meat quality biomarkers in holstein and simmental cattle.

Ali Murat Tatar
1.00
Animals Cattle Oxidative Stress Biomarkers Meat

Safety and tolerability of tegoprubart in patients with amyotrophic lateral sclerosis: A Phase 2A clinical trial.

Steven Perrin, Shafeeq Ladha, Nicholas Maragakis et al.
1.00
Humans Amyotrophic Lateral Sclerosis Male Middle Aged Female

Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Trichothioneic acid, a new antioxidant...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Trichothioneic acid, a new antioxidant...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Piégeurs de radicaux libres › Trichothioneic acid, a new antioxidant...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Chromatographie gazeuse-spectrométrie de masse › Trichothioneic acid, a new antioxidant...
questionsmedicales.fr › Eucaryotes › Champignons › Ascomycota › Hypocreales › Hypocrea › Trichothioneic acid, a new antioxidant...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Trichothioneic acid, a new antioxidant...
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Techniques microbiologiques › Trichothioneic acid, a new antioxidant...
questionsmedicales.fr › Eucaryotes › Champignons › Deuteromycota › Trichoderma › Trichothioneic acid, a new antioxidant...