Biological Evaluation, Molecular Docking, and SAR Studies of Novel 2-(2,4-Dihydroxyphenyl)-1
Acetylcholinesterase
/ metabolism
Amyloid beta-Peptides
/ antagonists & inhibitors
Animals
Antioxidants
/ chemical synthesis
Benzimidazoles
/ chemical synthesis
Biphenyl Compounds
/ antagonists & inhibitors
Butyrylcholinesterase
/ metabolism
Cholinesterase Inhibitors
/ chemical synthesis
Dose-Response Relationship, Drug
Horses
Humans
Kinetics
Molecular Docking Simulation
Peptide Fragments
/ antagonists & inhibitors
Picrates
/ antagonists & inhibitors
Protein Aggregates
/ drug effects
Structure-Activity Relationship
SAR
acetylcholinesterase
benzimidazole
beta amyloid
butyrylcholinesterase
inhibitor
lipophilicity
molecular docking
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
12 12 2019
12 12 2019
Historique:
received:
11
11
2019
revised:
09
12
2019
accepted:
10
12
2019
entrez:
18
12
2019
pubmed:
18
12
2019
medline:
17
9
2020
Statut:
epublish
Résumé
In the present study, new 4-(1
Identifiants
pubmed: 31842463
pii: biom9120870
doi: 10.3390/biom9120870
pmc: PMC6995558
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Antioxidants
0
Benzimidazoles
0
Biphenyl Compounds
0
Cholinesterase Inhibitors
0
Peptide Fragments
0
Picrates
0
Protein Aggregates
0
amyloid beta-protein (1-42)
0
1,1-diphenyl-2-picrylhydrazyl
DFD3H4VGDH
Acetylcholinesterase
EC 3.1.1.7
Butyrylcholinesterase
EC 3.1.1.8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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