Angiotensin-(1-7) induces beige fat thermogenesis through the Mas receptor.

Adipose Tissue, Beige / drug effects Adipose Tissue, White / drug effects Adult Angiotensin I / pharmacology Animals Cell Respiration / drug effects Cells, Cultured Energy Metabolism / genetics Female Humans Male Mice Mice, Inbred C57BL Mice, Knockout Middle Aged Obesity / genetics Peptide Fragments / pharmacology Proto-Oncogene Mas Proto-Oncogene Proteins / genetics Rats Rats, Transgenic Receptors, G-Protein-Coupled / genetics Thermogenesis / drug effects Young Adult

Adipose tissue Angiotensin-(1-7) Beige adipocytes Mas receptor Thermogenesis

Journal

Metabolism: clinical and experimental

ISSN: 1532-8600

Titre abrégé: Metabolism

Pays: United States

ID NLM: 0375267

Informations de publication

Date de publication:
02 2020

Historique:

received: 10 10 2019

revised: 06 12 2019

accepted: 11 12 2019

pubmed: 18 12 2019

medline: 28 4 2020

entrez: 18 12 2019

Statut: ppublish

Résumé

Angiotensin-(1-7) [Ang-(1-7)], a component of the renin angiotensin system, is a vasodilator that exerts its effects primarily through the Mas receptor. The discovery of the Mas receptor in white adipose tissue (WAT) suggests an additional role for this peptide. The aim of the present study was to assess whether Ang-(1-7) can induce the expression of thermogenic genes in white adipose tissue and increase mitochondrial respiration in adipocytes. Stromal Vascular fraction (SVF)-derived from mice adipose tissue was stimulated for one week with Ang-(1-7), then expression of beige markers and mitochondrial respiration were assessed. Mas Incubation of adipocytes derived from SVF with Ang-(1-7) increased the expression of beige markers. Infusion of Ang-(1-7) into lean and obese Mas These data indicate that Ang-(1-7) stimulates beige markers and thermogenesis via the Mas receptor, and this evidence suggests a potential therapeutic use to induce thermogenesis of WAT, particularly in obese subjects that have reduced circulating concentration of Ang-(1-7).

Identifiants

DOI: 10.1016/j.metabol.2019.154048 PMID: 31843339

pubmed: 31843339

pii: S0026-0495(19)30263-X

doi: 10.1016/j.metabol.2019.154048

pii:

doi:

Substances chimiques

Peptide Fragments 0

Proto-Oncogene Mas 0

Proto-Oncogene Proteins 0

Receptors, G-Protein-Coupled 0

Angiotensin I 9041-90-1

angiotensin I (1-7) IJ3FUK8MOF

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng