Time-kill curves of daptomycin and Monte Carlo simulation for the treatment of bacteraemia caused by Enterococcus faecium.
Bacteremia
/ drug therapy
Colony Count, Microbial
Computer Simulation
Daptomycin
/ pharmacokinetics
Enterococcus faecium
/ drug effects
Gram-Positive Bacterial Infections
/ blood
Humans
Microbial Sensitivity Tests
Models, Theoretical
Monte Carlo Method
Vancomycin-Resistant Enterococci
/ drug effects
Bacteraemia
Daptomycin
Enterococcus faecium
PK/PD modelling
Journal
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
ISSN: 1678-4405
Titre abrégé: Braz J Microbiol
Pays: Brazil
ID NLM: 101095924
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
26
12
2018
accepted:
22
11
2019
pubmed:
18
12
2019
medline:
11
11
2020
entrez:
18
12
2019
Statut:
ppublish
Résumé
The aim of this study was to investigate the effect of daptomycin against vancomycin-resistant Enterococcus faecium bacteraemia using computer modelling. Data obtained in vitro from time-kill curves were evaluated by PK/PD modelling and Monte Carlo simulations to determine the logarithmic reduction in the number of colony-forming units (CFU)/mL over 18 days of daptomycin treatment at 6, 8, and 10 mg/kg doses every 24 or 48 h and with variations in creatinine clearance (CL Static time-kill model was employed to investigate the antibacterial efficacy of constant daptomycin concentrations. The time-kill curve analysis was performed using mathematical modelling based on a Hill coefficient factor. There was an expressive reduction (> 2 Log CFU/mL) over 18 days of daptomycin treatment in 75th percentile of individuals with CL Higher daptomycin doses were associated with higher mortality in time-kill curves. The simulations indicated that independent of the CL
Identifiants
pubmed: 31845296
doi: 10.1007/s42770-019-00200-4
pii: 10.1007/s42770-019-00200-4
pmc: PMC7058735
doi:
Substances chimiques
Daptomycin
NWQ5N31VKK
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
169-176Références
Diagn Microbiol Infect Dis. 2014 Apr;78(4):429-36
pubmed: 24440509
Drug Discov Today Technol. 2016 Sep - Dec;21-22:41-49
pubmed: 27978987
Nat Rev Microbiol. 2012 Mar 16;10(4):266-78
pubmed: 22421879
J Antimicrob Chemother. 2010 Jun;65(6):1126-36
pubmed: 20363805
Antimicrob Agents Chemother. 2006 Oct;50(10):3245-9
pubmed: 17005801
Clin Microbiol Rev. 2014 Oct;27(4):647-64
pubmed: 25278570
Pharmacology. 2008;81(2):79-91
pubmed: 17940348
Clin Infect Dis. 2017 Apr 15;64(8):1026-1034
pubmed: 28329222
Adv Ther. 2015 Dec;32(12):1192-205
pubmed: 26610384
Clin Ther. 2010 Sep;32(10):1713-9
pubmed: 21194593
Antimicrob Agents Chemother. 2011 Oct;55(10):4619-30
pubmed: 21807983
Infect Dis (Lond). 2015;47(12):846-51
pubmed: 26167850
Infect Control Hosp Epidemiol. 2013 Jan;34(1):1-14
pubmed: 23221186
J Antimicrob Chemother. 2011 Sep;66(9):2112-8
pubmed: 21697178
Int J Antimicrob Agents. 2013 Sep;42(3):202-10
pubmed: 23845504
Int J Antimicrob Agents. 2013 Sep;42(3):250-5
pubmed: 23891432
J Pharmacokinet Pharmacodyn. 2007 Dec;34(6):727-51
pubmed: 17906920
J Antimicrob Chemother. 2017 Aug 1;72(8):2342-2350
pubmed: 28575511
Future Microbiol. 2006 Oct;1(3):255-65
pubmed: 17661638
J Antimicrob Chemother. 2005 May;55(5):601-7
pubmed: 15772142
Pharmacol Rev. 2013 Jun 26;65(3):1053-90
pubmed: 23803529
Clin Infect Dis. 2004 Jun 15;38(12):1673-81
pubmed: 15227611
Antimicrob Agents Chemother. 2018 Sep 24;62(10):
pubmed: 30012755
Antimicrob Agents Chemother. 2012 Nov;56(11):5626-32
pubmed: 22908174
J Antimicrob Chemother. 2007 Aug;60(2):334-40
pubmed: 17540670
Clin Infect Dis. 2016 Jun 15;62(12):1514-1520
pubmed: 27045126
Infect Drug Resist. 2015 Jul 24;8:217-30
pubmed: 26244026
Int J Antimicrob Agents. 2007 Mar;29(3):263-70
pubmed: 17194570
Clin Ther. 2016 Nov;38(11):2468-2476
pubmed: 27771176
Eur J Med Res. 2010 Nov 30;15(12):533-43
pubmed: 21163728
Curr Opin Microbiol. 2000 Oct;3(5):515-21
pubmed: 11050452
Antimicrob Agents Chemother. 2013 Sep;57(9):4190-6
pubmed: 23774437
Ann Pharmacother. 2009 Jul;43(7):1211-9
pubmed: 19584384