7,8-Dihydro-8-oxoguanosine Lesions Inhibit the Theophylline Aptamer or Change Its Selectivity.

Aptamers, Nucleotide / chemistry Guanosine / analogs & derivatives Humans Magnetic Resonance Spectroscopy Nucleic Acid Conformation Theophylline / chemistry
8-oxoG RNA structures aptamers oxidation thermophoresis

Journal

Chembiochem : a European journal of chemical biology
ISSN: 1439-7633
Titre abrégé: Chembiochem
Pays: Germany
ID NLM: 100937360

Informations de publication

Date de publication:
04 05 2020
Historique:
received: 09 11 2019
pubmed: 18 12 2019
medline: 29 5 2021
entrez: 18 12 2019
Statut: ppublish

Résumé

Aptamers are attractive constructs due to their high affinity/selectivity towards a target. Here 7,8-dihydro-8-oxoguanosine (8-oxoG) has been used, due in part to its unique H-bonding capabilities (Watson-Crick or Hoogsteen), to expand the "RNA alphabet". Its impact on the theophylline RNA aptamer was explored by modifying its binding pocket at positions G11, G25, or G26. Structural probing, with RNases A and T

Identifiants

DOI: 10.1002/cbic.201900684 PMID: 31845489 PMC: PMC7297664
pubmed: 31845489
doi: 10.1002/cbic.201900684
pmc: PMC7297664
mid: NIHMS1596131
doi:

Substances chimiques

Aptamers, Nucleotide 0
Guanosine 12133JR80S
8-hydroxyguanosine 3868-31-3
Theophylline C137DTR5RG

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

1347-1355

Subventions

Organisme : NIGMS NIH HHS
ID : R15 GM132816
Pays : United States

Informations de copyright

© 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

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Auteurs

Courtney Kiggins (C)

Present address: Department of Chemistry, U.S. Air Force Academy, 2355 Fairchild Drive, USAF Academy, Colorado Springs, CO, 80840, USA.

Austin Skinner (A)

Department of Chemistry, University of Colorado Denver, 1151 Arapahoe Street, Science Building Room 4145, Denver, CO, 80204, USA.

Marino J E Resendiz (MJE)

Department of Chemistry, University of Colorado Denver, 1151 Arapahoe Street, Science Building Room 4145, Denver, CO, 80204, USA.
ORCID: 0000-0001-5631-2722

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Polynucléotides › Oligonucléotides › Aptamères nucléotidiques › 7,8-Dihydro-8-oxoguanosine Lesions Inhibit the...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Guanosine › 7,8-Dihydro-8-oxoguanosine Lesions Inhibit the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › 7,8-Dihydro-8-oxoguanosine Lesions Inhibit the...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › 7,8-Dihydro-8-oxoguanosine Lesions Inhibit the...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › 7,8-Dihydro-8-oxoguanosine Lesions Inhibit the...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › Purinones › Xanthines › Théophylline › 7,8-Dihydro-8-oxoguanosine Lesions Inhibit the...