The Interaction of Sodium and Zinc in the Priming of T Cell Subpopulations Regarding Th17 and Treg Cells.
Cation Transport Proteins
/ genetics
Cells, Cultured
Forkhead Transcription Factors
/ metabolism
Gene Expression Regulation
/ drug effects
Humans
Jurkat Cells
Metallothionein
/ genetics
Nuclear Receptor Subfamily 1, Group F, Member 3
/ metabolism
Phosphoric Monoester Hydrolases
/ metabolism
Signal Transduction
/ drug effects
Smad Proteins
/ metabolism
Sodium
/ metabolism
T-Lymphocytes, Regulatory
/ drug effects
Th17 Cells
/ drug effects
Zinc
/ metabolism
Foxp3
T helper 17 cells
regulatory T cells
sodium
zinc
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
11
03
2019
revised:
22
10
2019
pubmed:
18
12
2019
medline:
15
1
2021
entrez:
18
12
2019
Statut:
ppublish
Résumé
Nutrition is a critical determinant of a functional immune system. The aim of this study is to investigate the molecular mechanisms by which immune cells are influenced by zinc and sodium. Mixed lymphocyte cultures and Jurkat cells are generated and incubated with zinc, sodium, or a combination of both for further tests. Zinc induces the number of regulatory T cells (Treg) and decreases T helper 17 cells (Th17), and sodium has the opposite effect. The transforming growth factor beta receptor signaling pathway is also enhanced by zinc and reduced by sodium as indicated by contrary phosphoSmad 2/3 induction. Antagonistic effects can also be seen on zinc transporter and metallothionein-1 (MT-1) mRNA expression: zinc declines Zip10 mRNA expression while sodium induces it, whereas MT-1 mRNA expression is induced by zinc while it is reduced by sodium. This data indicate that zinc and sodium display opposite effects regarding Treg and Th17 induction in MLC, respectively, resulting in a contrary effect on the immune system. Additionally, it reveals a direct interaction of zinc and sodium in the priming of T cell subpopulations and shows that Zip10 and MT-1 play a significant role in those differentiation pathways.
Identifiants
pubmed: 31845513
doi: 10.1002/mnfr.201900245
doi:
Substances chimiques
Cation Transport Proteins
0
FOXP3 protein, human
0
Forkhead Transcription Factors
0
Nuclear Receptor Subfamily 1, Group F, Member 3
0
RORC protein, human
0
SLC39A10 protein, human
0
Smad Proteins
0
Metallothionein
9038-94-2
Sodium
9NEZ333N27
Phosphoric Monoester Hydrolases
EC 3.1.3.2
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1900245Informations de copyright
© 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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