A Single-Turnover Kinetic Study of DNA Demethylation Catalyzed by Fe(II)/α-Ketoglutarate-Dependent Dioxygenase AlkB.
DNA demethylation
FRET analysis
conformational dynamics
dioxygenase AlkB
fluorescent probes
protein–DNA interactions
single-turnover kinetics
stopped-flow method
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
13 Dec 2019
13 Dec 2019
Historique:
received:
17
10
2019
revised:
26
11
2019
accepted:
11
12
2019
entrez:
19
12
2019
pubmed:
19
12
2019
medline:
15
5
2020
Statut:
epublish
Résumé
AlkB is a Fe(II)/α-ketoglutarate-dependent dioxygenase that repairs some alkylated bases of DNA and RNA in
Identifiants
pubmed: 31847292
pii: molecules24244576
doi: 10.3390/molecules24244576
pmc: PMC6943663
pii:
doi:
Substances chimiques
DNA, Single-Stranded
0
Escherichia coli Proteins
0
Fluorescent Dyes
0
Oligonucleotides
0
DNA
9007-49-2
Mixed Function Oxygenases
EC 1.-
AlkB protein, E coli
EC 1.14.11.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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