Efficacy and safety of oral hyoscine used for outpatient cervical ripening among primiparous women with term pregnancy.
Cervical ripening
Hyoscine
Outpatient
Randomized controlled trial
Journal
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
ISSN: 1879-3479
Titre abrégé: Int J Gynaecol Obstet
Pays: United States
ID NLM: 0210174
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
08
05
2019
revised:
27
10
2019
accepted:
16
12
2019
pubmed:
19
12
2019
medline:
9
3
2021
entrez:
19
12
2019
Statut:
ppublish
Résumé
To assess the efficacy and safety of outpatient administration of oral hyoscine for cervical ripening. In a randomized controlled trial at a university hospital in Tehran between September 2017 and December 2018, 100 primiparous women with singleton pregnancy at 38 Mean ± SD Bishop score in the hyoscine and control groups was, respectively, 1.19 ± 1.38 and 1.08 ± 1.70 at baseline, and 4.56 ± 2.87 and 2.76 ± 2.14 on admission for delivery (P=0.001). Duration of the first stage was 4.10 ± 5.49 hours in the hyoscine and 5.29 ± 6.48 hours in the control group (P=0.03). Duration of the second and third stages was, respectively, 0.52 ± 0.53 and 0.14 ± 0.25 hours in the hyoscine, and 0.59 ± 1.08 and 0.12 ± 0.15 hours in the control group. No adverse effects were reported. Administration of oral hyoscine in an outpatient setting was found to ripen the cervix with no clinically significant adverse drug reaction. IRANIAN REGISTRY OF CLINICAL TRIALS (IRCT20180819040830N1).
Substances chimiques
Scopolamine
DL48G20X8X
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
335-339Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2019 International Federation of Gynecology and Obstetrics.
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