Discovery of Procognitive Antipsychotics by Combining Muscarinic M

Animals Antipsychotic Agents / pharmacology Clozapine / analogs & derivatives Drug Discovery / methods Receptor, Muscarinic M1 / agonists Structure-Activity Relationship Zebrafish
N-desmethylclozapine Zebrafish antipsychotics behavioral profiling muscarinic agonist structure−activity relationship

Journal

ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337

Informations de publication

Date de publication:
15 01 2020
Historique:
pubmed: 19 12 2019
medline: 22 12 2020
entrez: 19 12 2019
Statut: ppublish

Résumé

Current antipsychotic drugs are notably ineffective at addressing the cognitive deficits associated with schizophrenia.

Identifiants

DOI: 10.1021/acschemneuro.9b00524 PMID: 31850734
pubmed: 31850734
doi: 10.1021/acschemneuro.9b00524
doi:

Substances chimiques

Antipsychotic Agents 0
Receptor, Muscarinic M1 0
norclozapine 1I9001LWY8
Clozapine J60AR2IKIC

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

173-183

Auteurs

Karin Hellman (K)

Chemical Biology and Therapeutics, Department of Experimental Medical Science , Lund University , SE-221 84 Lund , Sweden.

Jörgen Ohlsson (J)

Chemical Biology and Therapeutics, Department of Experimental Medical Science , Lund University , SE-221 84 Lund , Sweden.

Marcus Malo (M)

Department of Chemistry and Molecular Biology , University of Gothenburg , SE-405 30 Gothenburg , Sweden.

Roger Olsson (R)

Chemical Biology and Therapeutics, Department of Experimental Medical Science , Lund University , SE-221 84 Lund , Sweden.
Department of Chemistry and Molecular Biology , University of Gothenburg , SE-405 30 Gothenburg , Sweden.
ORCID: 0000-0002-7107-3472

Fredrik Ek (F)

Chemical Biology and Therapeutics, Department of Experimental Medical Science , Lund University , SE-221 84 Lund , Sweden.
ORCID: 0000-0002-5651-8445

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Discovery of Procognitive Antipsychotics by...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Psychoanaleptiques › Tranquillisants › Neuroleptiques › Discovery of Procognitive Antipsychotics by...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Dibenzazépines › Clozapine › Discovery of Procognitive Antipsychotics by...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Discovery of Procognitive Antipsychotics by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs cholinergiques › Récepteur muscarinique › Récepteur muscarinique de type M1 › Discovery of Procognitive Antipsychotics by...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Discovery of Procognitive Antipsychotics by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Discovery of Procognitive Antipsychotics by...