Effects of short-term aerobic exercise in a mouse model of Niemann-Pick type C disease on synaptic and muscle plasticity.
Aerobiosis
Animals
CA1 Region, Hippocampal
/ physiopathology
Genotype
Intracellular Signaling Peptides and Proteins
/ deficiency
Long-Term Potentiation
Male
Mice
Mice, Inbred BALB C
Models, Animal
Muscular Atrophy
/ etiology
Niemann-Pick C1 Protein
Niemann-Pick Disease, Type C
/ complications
Physical Conditioning, Animal
Rotarod Performance Test
Sarcomeres
/ ultrastructure
Journal
Annali dell'Istituto superiore di sanita
ISSN: 2384-8553
Titre abrégé: Ann Ist Super Sanita
Pays: Italy
ID NLM: 7502520
Informations de publication
Date de publication:
Historique:
entrez:
19
12
2019
pubmed:
19
12
2019
medline:
19
5
2020
Statut:
ppublish
Résumé
Physical exercise can reduce the risk of developing chronic diseases and slow the onset of neurodegenerative diseases. Since it has not been assessed which kind of training protocol might positively modulate both synaptic and muscular plasticity in neurodegenerative diseases, we studied in a mouse model of Niemann Pick type C disease, a model of minimal Alzheimer's Disease, the effect of a short term protocol. We evaluated the effect of a short term, aerobic uniform exercise training on synaptic and muscle plasticity in three different mice groups: WT controls, NPC1+/- and NPC1-/- animals. The results were compared with those obtained in the sedentary respective groups. We analyzed the effects on synaptic plasticity by in vitro extracellular recordings in hippocampal mouse slices; moreover hippocampal and muscle tissue morphological structure have been investigated by transmission electron microscopy, to highlight any structural and functional changes due to training. The results indicate a rescue of long-term potentiation in homozygous but not in heterozygous mice slices and an induction of neuronal plasticity, observed by morphological analysis, both in homozygous and in heterozygous trained mice. Hence this protocol is adequate to improve long term potentiation (LTP) impairment and counteract muscular deterioration in homozygous mice.
Sections du résumé
BACKGROUND
BACKGROUND
Physical exercise can reduce the risk of developing chronic diseases and slow the onset of neurodegenerative diseases. Since it has not been assessed which kind of training protocol might positively modulate both synaptic and muscular plasticity in neurodegenerative diseases, we studied in a mouse model of Niemann Pick type C disease, a model of minimal Alzheimer's Disease, the effect of a short term protocol.
METHODS
METHODS
We evaluated the effect of a short term, aerobic uniform exercise training on synaptic and muscle plasticity in three different mice groups: WT controls, NPC1+/- and NPC1-/- animals. The results were compared with those obtained in the sedentary respective groups. We analyzed the effects on synaptic plasticity by in vitro extracellular recordings in hippocampal mouse slices; moreover hippocampal and muscle tissue morphological structure have been investigated by transmission electron microscopy, to highlight any structural and functional changes due to training.
RESULTS
RESULTS
The results indicate a rescue of long-term potentiation in homozygous but not in heterozygous mice slices and an induction of neuronal plasticity, observed by morphological analysis, both in homozygous and in heterozygous trained mice.
CONCLUSIONS
CONCLUSIONS
Hence this protocol is adequate to improve long term potentiation (LTP) impairment and counteract muscular deterioration in homozygous mice.
Identifiants
pubmed: 31850859
doi: 10.4415/ANN_19_04_05
doi:
Substances chimiques
Intracellular Signaling Peptides and Proteins
0
Niemann-Pick C1 Protein
0
Npc1 protein, mouse
0
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM