Platelet-derived β2m regulates age related monocyte/macrophage functions.
aging
heart
inflammation
monocytes
platelets
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
18 12 2019
18 12 2019
Historique:
received:
29
08
2019
accepted:
18
11
2019
pubmed:
20
12
2019
medline:
22
10
2020
entrez:
20
12
2019
Statut:
ppublish
Résumé
Platelets have central roles in both immune responses and development. Stimulated platelets express leukocyte adhesion molecules and release numerous immune modulatory factors that recruit and activate leukocytes, both at the sites of activation and distantly. Monocytes are innate immune cells with dynamic immune modulatory functions that change during the aging process, a phenomenon termed "inflammaging". We have previously shown that platelets are a major source of plasma beta-2 microglobulin (β2M) and that β2M induced a monocyte pro-inflammatory phenotype. Plasma β2M increases with age and is a pro-aging factor. We hypothesized that platelet derived β2M regulates monocyte phenotypes in the context of aging. Using wild-type (WT) and platelet specific β2M knockout mice (Plt-β2M
Identifiants
pubmed: 31852838
pii: 102520
doi: 10.18632/aging.102520
pmc: PMC6949047
doi:
Substances chimiques
beta 2-Microglobulin
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
11955-11974Subventions
Organisme : NHLBI NIH HHS
ID : F31 HL145922
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL141106
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142152
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002001
Pays : United States
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