Tailored eradication
Aged
Amoxicillin
/ therapeutic use
Antacids
/ therapeutic use
Anti-Bacterial Agents
/ therapeutic use
Bismuth
/ therapeutic use
Clarithromycin
/ therapeutic use
Drug Therapy, Combination
Female
Helicobacter Infections
/ drug therapy
Helicobacter pylori
Humans
Male
Medication Adherence
/ statistics & numerical data
Metronidazole
/ therapeutic use
Middle Aged
Point Mutation
Precision Medicine
/ statistics & numerical data
Proton Pump Inhibitors
/ therapeutic use
RNA, Ribosomal, 23S
/ genetics
Retrospective Studies
Helicobacter pylori
Empirical
Eradication
Quadruple
Tailored
Journal
World journal of gastroenterology
ISSN: 2219-2840
Titre abrégé: World J Gastroenterol
Pays: United States
ID NLM: 100883448
Informations de publication
Date de publication:
14 Dec 2019
14 Dec 2019
Historique:
received:
27
09
2019
revised:
30
11
2019
accepted:
07
12
2019
entrez:
21
12
2019
pubmed:
21
12
2019
medline:
6
5
2020
Statut:
ppublish
Résumé
Few studies have compared the efficacy and safety profile of a tailored eradication (TR) strategy based on the presence of a 23S ribosomal RNA point mutation with those of empirical bismuth-based quadruple therapy (EBQT) for first-line eradication of To compare the efficacy and safety of a TR strategy and those of EBQT regimen as first-line eradication therapy for This is an open-label, comparative study in which we prospectively enrolled patients over 18 years of age with A total of 150 patients were assigned to the TR ( DPO-PCR-based TR for
Sections du résumé
BACKGROUND
BACKGROUND
Few studies have compared the efficacy and safety profile of a tailored eradication (TR) strategy based on the presence of a 23S ribosomal RNA point mutation with those of empirical bismuth-based quadruple therapy (EBQT) for first-line eradication of
AIM
OBJECTIVE
To compare the efficacy and safety of a TR strategy and those of EBQT regimen as first-line eradication therapy for
METHODS
METHODS
This is an open-label, comparative study in which we prospectively enrolled patients over 18 years of age with
RESULTS
RESULTS
A total of 150 patients were assigned to the TR (
CONCLUSION
CONCLUSIONS
DPO-PCR-based TR for
Identifiants
pubmed: 31857776
doi: 10.3748/wjg.v25.i46.6743
pmc: PMC6920661
doi:
Substances chimiques
Antacids
0
Anti-Bacterial Agents
0
Proton Pump Inhibitors
0
RNA, Ribosomal, 23S
0
Metronidazole
140QMO216E
Amoxicillin
804826J2HU
Clarithromycin
H1250JIK0A
Bismuth
U015TT5I8H
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6743-6751Informations de copyright
©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.
Références
Int J Mol Sci. 2017 Aug 03;18(8):null
pubmed: 28771198
Am J Gastroenterol. 2014 Oct;109(10):1595-602
pubmed: 25091062
Jpn J Infect Dis. 2015;68(3):176-80
pubmed: 25672355
Helicobacter. 2019 Apr;24(2):e12561
pubmed: 30632237
J Gastrointestin Liver Dis. 2017 Sep;26(3):225-229
pubmed: 28922433
J Gastroenterol Hepatol. 2014;29(7):1371-86
pubmed: 24758240
Helicobacter. 2017 Aug;22(4):null
pubmed: 28425141
Helicobacter. 2019 Feb;24(1):e12546
pubmed: 30346636
Eur J Gastroenterol Hepatol. 2015 Mar;27(3):221-5
pubmed: 25629566
Helicobacter. 2019 Apr;24(2):e12565
pubmed: 30698318
PLoS One. 2017 Sep 28;12(9):e0183302
pubmed: 28957341
World J Gastroenterol. 2014 Jun 7;20(21):6547-53
pubmed: 24914376
Eur J Gastroenterol Hepatol. 2012 Apr;9 Suppl 1:S3-6; discussion S6-7
pubmed: 22498905
World J Gastroenterol. 2018 Oct 28;24(40):4548-4553
pubmed: 30386104
Microb Drug Resist. 2016 Apr;22(3):227-32
pubmed: 26618567
Gut. 2017 Jan;66(1):6-30
pubmed: 27707777
Helicobacter. 2018 Sep;23 Suppl 1:e12522
pubmed: 30203583
BMC Gastroenterol. 2011 Oct 17;11:112
pubmed: 22004003
Int J Med Sci. 2017 May 15;14(6):595-601
pubmed: 28638276
J Gastroenterol Hepatol. 2019 Apr;34(4):700-706
pubmed: 30011083
BMC Gastroenterol. 2016 Jul 26;16(1):79
pubmed: 27460100
Cancer Lett. 2014 Apr 10;345(2):196-202
pubmed: 23981572
Medicine (Baltimore). 2015 Nov;94(47):e2056
pubmed: 26632710
Helicobacter. 2016 Apr;21(2):91-9
pubmed: 26104022
Gastroenterology. 2016 May;150(5):1113-1124.e5
pubmed: 26836587
J Gastroenterol Hepatol. 2012 Nov;27(11):1675-80
pubmed: 22849546
Medicine (Baltimore). 2018 Aug;97(33):e11835
pubmed: 30113472
World J Gastroenterol. 2018 Jul 28;24(28):3071-3089
pubmed: 30065554
Gut Liver. 2018 Nov 15;12(6):641-647
pubmed: 30037168
Gut Liver. 2017 Sep 15;11(5):648-654
pubmed: 28750485