Sex-dependent effects of Cacna1c haploinsufficiency on behavioral inhibition evoked by conspecific alarm signals in rats.
Ca(v)1.2
Calcium
Sex differences
Social behavior
Ultrasonic vocalizations
Journal
Progress in neuro-psychopharmacology & biological psychiatry
ISSN: 1878-4216
Titre abrégé: Prog Neuropsychopharmacol Biol Psychiatry
Pays: England
ID NLM: 8211617
Informations de publication
Date de publication:
20 04 2020
20 04 2020
Historique:
received:
16
09
2019
revised:
13
12
2019
accepted:
16
12
2019
pubmed:
22
12
2019
medline:
1
4
2021
entrez:
22
12
2019
Statut:
ppublish
Résumé
Deficits in processing social signals leads to reduced social functioning and is typically associated with neuropsychiatric disorders, including autism spectrum disorder, schizophrenia, and major depressive disorder. The cross-disorder risk gene CACNA1C is implicated in the etiology of all of these disorders and single-nucleotide polymorphisms within CACNA1C are ranked among the best replicated and most robust genetic findings from genome-wide association studies in psychiatry. Rats are highly social, live in large social groups, and communicate through ultrasonic vocalizations (USV), with low-frequency 22-kHz USV emitted in dangerous and often life-threating situations, such as predator exposure, serving an alarming function. In the present study, we applied an alarm 22-kHz USV playback paradigm to investigate the role of Cacna1c in socio-affective information processing in rats. Specifically, we assessed behavioral inhibition evoked by 22-kHz USV in constitutive heterozygous Cacna1c
Identifiants
pubmed: 31862418
pii: S0278-5846(19)30778-X
doi: 10.1016/j.pnpbp.2019.109849
pii:
doi:
Substances chimiques
Cacna1c protein, rat
0
Calcium Channels, L-Type
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
109849Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest M.W. is scientific advisor of Avisoft Bioacoustics. The other authors declare no competing interests.