Serum growth differentiation factor 15, but not lactate, is elevated in patients with Parkinson's disease.
GDF15
Lactate
Lactate stress test
Mitochondria
Parkinson's disease
Journal
Journal of the neurological sciences
ISSN: 1878-5883
Titre abrégé: J Neurol Sci
Pays: Netherlands
ID NLM: 0375403
Informations de publication
Date de publication:
15 Feb 2020
15 Feb 2020
Historique:
received:
21
09
2019
revised:
29
11
2019
accepted:
04
12
2019
pubmed:
22
12
2019
medline:
20
3
2021
entrez:
22
12
2019
Statut:
ppublish
Résumé
Parkinson's disease (PD) is among the most frequently-occurring neurodegenerative diseases in humans. Although mitochondrial dysfunction is suggested to play a central role in PD pathogenesis, few studies have clinically evaluated mitochondrial function in PD patients. We therefore aimed to determine whether mitochondrial function is altered in PD patients by applying two approaches that are normally used for the diagnosis of mitochondrial disorder (MD). We measured serum growth differentiation factor 15 (GDF15) levels in 36 PD patients, 30 age-matched healthy controls, and 5 MD patients. Among these, 20 PD patients and 18 healthy controls underwent the lactate stress test. Serum GDF15 levels were evaluated with respect to clinical characteristics. Mean GDF15 levels were significantly higher in the PD (1472 pg/mL, p = .034) and MD (3363 pg/mL, p < .001) groups than in the control group (1093 pg/mL). The lactate stress test exhibited no significant differences between PD patients and controls. Age was identified as an independent factor that correlated with serum GDF15 levels in both groups. In PD patients, there was no significant difference between serum GDF15 levels and other clinical parameters including sex, cognitive function, and lifestyle. Serum GDF15 levels, but not lactate levels, were elevated in Japanese patients with PD, thus highlighting the potential association between PD and GDF15.
Sections du résumé
BACKGROUND
BACKGROUND
Parkinson's disease (PD) is among the most frequently-occurring neurodegenerative diseases in humans. Although mitochondrial dysfunction is suggested to play a central role in PD pathogenesis, few studies have clinically evaluated mitochondrial function in PD patients. We therefore aimed to determine whether mitochondrial function is altered in PD patients by applying two approaches that are normally used for the diagnosis of mitochondrial disorder (MD).
METHODS
METHODS
We measured serum growth differentiation factor 15 (GDF15) levels in 36 PD patients, 30 age-matched healthy controls, and 5 MD patients. Among these, 20 PD patients and 18 healthy controls underwent the lactate stress test. Serum GDF15 levels were evaluated with respect to clinical characteristics.
RESULTS
RESULTS
Mean GDF15 levels were significantly higher in the PD (1472 pg/mL, p = .034) and MD (3363 pg/mL, p < .001) groups than in the control group (1093 pg/mL). The lactate stress test exhibited no significant differences between PD patients and controls. Age was identified as an independent factor that correlated with serum GDF15 levels in both groups. In PD patients, there was no significant difference between serum GDF15 levels and other clinical parameters including sex, cognitive function, and lifestyle.
CONCLUSION
CONCLUSIONS
Serum GDF15 levels, but not lactate levels, were elevated in Japanese patients with PD, thus highlighting the potential association between PD and GDF15.
Identifiants
pubmed: 31862518
pii: S0022-510X(19)32381-0
doi: 10.1016/j.jns.2019.116616
pii:
doi:
Substances chimiques
Biomarkers
0
GDF15 protein, human
0
Growth Differentiation Factor 15
0
Lactic Acid
33X04XA5AT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
116616Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.