Relationship between gut microbiota and circulating metabolites in population-based cohorts.
Acute-Phase Proteins
/ isolation & purification
Adult
Amino Acids
/ blood
Bacteria
/ genetics
Cohort Studies
DNA, Bacterial
/ isolation & purification
Feces
/ microbiology
Female
Gastrointestinal Microbiome
/ physiology
Glycolysis
/ physiology
Host Microbial Interactions
/ physiology
Humans
Lipoproteins, HDL
/ blood
Male
Metabolome
/ physiology
Metabolomics
/ methods
Middle Aged
Netherlands
Proton Magnetic Resonance Spectroscopy
RNA, Ribosomal, 16S
/ genetics
Regression Analysis
Triglycerides
/ blood
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
20 12 2019
20 12 2019
Historique:
received:
27
03
2019
accepted:
13
11
2019
entrez:
22
12
2019
pubmed:
22
12
2019
medline:
9
4
2020
Statut:
epublish
Résumé
Gut microbiota has been implicated in major diseases affecting the human population and has also been linked to triglycerides and high-density lipoprotein levels in the circulation. Recent development in metabolomics allows classifying the lipoprotein particles into more details. Here, we examine the impact of gut microbiota on circulating metabolites measured by Nuclear Magnetic Resonance technology in 2309 individuals from the Rotterdam Study and the LifeLines-DEEP cohort. We assess the relationship between gut microbiota and metabolites by linear regression analysis while adjusting for age, sex, body-mass index, technical covariates, medication use, and multiple testing. We report an association of 32 microbial families and genera with very-low-density and high-density subfractions, serum lipid measures, glycolysis-related metabolites, ketone bodies, amino acids, and acute-phase reaction markers. These observations provide insights into the role of microbiota in host metabolism and support the potential of gut microbiota as a target for therapeutic and preventive interventions.
Identifiants
pubmed: 31862950
doi: 10.1038/s41467-019-13721-1
pii: 10.1038/s41467-019-13721-1
pmc: PMC6925111
doi:
Substances chimiques
Acute-Phase Proteins
0
Amino Acids
0
DNA, Bacterial
0
Lipoproteins, HDL
0
RNA, Ribosomal, 16S
0
Triglycerides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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