Reduced plasma Fetuin-A is a promising biomarker of depression in the elderly.
Biomarkers
Elderly
Fetuin-A
Major depression
Neuroinflammation
Prolactin
Journal
European archives of psychiatry and clinical neuroscience
ISSN: 1433-8491
Titre abrégé: Eur Arch Psychiatry Clin Neurosci
Pays: Germany
ID NLM: 9103030
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
01
04
2019
accepted:
11
12
2019
pubmed:
22
12
2019
medline:
29
6
2021
entrez:
22
12
2019
Statut:
ppublish
Résumé
Depression affects 7% of the elderly population, and it often remains misdiagnosed or untreated. Peripheral biomarkers might aid clinicians by allowing more accurate and well-timed recognition of the disease. We sought to determine if plasma protein levels predict the severity of depressive symptomatology or distinguish patients from healthy individuals. The severity of depressive symptoms and global cognitive functioning were assessed by the Geriatric Depression Scale (GDS) and Mini-Mental State Examination (MMSE) in 152 elderly subjects, 76 of which with major depressive disorder (MDD). Plasma levels of 24 proteins were measured by multiplexing and analyzed as continuous predictors or dichotomized using the median value. The association between individual plasma proteins and MDD risk or depressive symptoms severity was investigated using multiple logistic and linear regressions including relevant covariates. Sensitivity analyses were performed excluding cognitively impaired individuals or non-acute patients with MDD. After adjusting for possible confounders and false discovery rate (FDR) correction, we found lower Fetuin-A levels in MDD patients vs. controls (p
Identifiants
pubmed: 31863164
doi: 10.1007/s00406-019-01090-1
pii: 10.1007/s00406-019-01090-1
doi:
Substances chimiques
AHSG protein, human
0
Biomarkers
0
alpha-2-HS-Glycoprotein
0
Prolactin
9002-62-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
901-910Subventions
Organisme : Korean Health Technology R&D Project, Ministry of Health & Welfare
ID : HC15C1405
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